scholarly journals White Blood Cell Count Predicts All-cause Mortality in Patients with Suspected Peripheral Arterial Disease

2010 ◽  
Vol 51 (5) ◽  
pp. 1322
Author(s):  
F.A. Arain ◽  
M. Khaleghi ◽  
K.R. Bailey
2009 ◽  
Vol 122 (9) ◽  
pp. 874.e1-874.e7 ◽  
Author(s):  
Faisal A. Arain ◽  
Mahyar Khaleghi ◽  
Kent R. Bailey ◽  
Brian D. Lahr ◽  
Thom W. Rooke ◽  
...  

2013 ◽  
Vol 48 (2) ◽  
pp. 103-108 ◽  
Author(s):  
Kwang-Il Kim ◽  
Jaebong Lee ◽  
Nam Ju Heo ◽  
Sejoong Kim ◽  
Ho Jun Chin ◽  
...  

Genes ◽  
2020 ◽  
Vol 11 (11) ◽  
pp. 1305
Author(s):  
Wilfried Renner ◽  
Melanie Kaiser ◽  
Sebastian Khuen ◽  
Olivia Trummer ◽  
Harald Mangge ◽  
...  

Background: Erythropoietin has a pivotal role in erythropoiesis and angiogenesis. A common polymorphism (rs1617640, A > C) in the promoter of the erythropoietin gene (EPO) has been associated with erythropoietin expression and microvascular complications of diabetes. We aimed to analyze the potential role of this polymorphism in the pathogenesis of peripheral arterial disease (PAD). Methods: EPO genotypes and laboratory markers for erythropoiesis were determined in 945 patients with PAD. Results: The minor EPO rs1617640 C-allele was associated in an allele-dose-dependent manner with hemoglobin levels (p = 0.006), hematocrit (p = 0.029), and red blood cell count (p = 0.003). In a multivariate linear regression analysis including conventional risk factors diabetes, sex, and smoking, EPO genotypes were furthermore associated with age at onset of PAD symptoms (p = 0.009). Conclusions: The EPO rs1617640 gene polymorphism affects erythropoiesis, leads to an earlier onset of PAD, and is a potential biomarker for the pathogenesis of this disease.


Foods ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1268
Author(s):  
Álvaro Hernáez ◽  
Camille Lassale ◽  
Sara Castro-Barquero ◽  
Nancy Babio ◽  
Emilio Ros ◽  
...  

We aimed to assess the effects of the antioxidant-rich Mediterranean diet (MedDiet) on white blood cell count. Our study population included participants in the PREvención con DIeta MEDiterránea study (average age 67 years old, 58% women, high cardiovascular risk). We assessed whether a MedDiet intervention enriched in extra-virgin olive oil or nuts, versus a low-fat control diet, modified the incidence of leukocytosis (>11 × 109 leukocytes/L), mild leukopenia (<4.5 × 109 leukocytes/L), or severe leukopenia (<3.5 × 109 leukocytes/L) in individuals without the condition at baseline (n = 3190, n = 2925, and n = 3190, respectively). We also examined whether MedDiet modified the association between leukocyte count alterations and all-cause mortality. Both MedDiet interventions were associated with a lower risk of developing leukopenia (incidence rates: 5.06% in control diet, 3.29% in MedDiet groups combined; hazard ratio [95% confidence interval]: 0.54 [0.36–0.80]) and severe leukopenia (incidence rates: 1.26% in control diet, 0.46% in MedDiet groups combined; hazard ratio: 0.25 [0.10–0.60]). High cumulative adherence to a MedDiet was linked to lower risk of leukocytosis (incidence rates: 2.08% in quartile 1, 0.65% in quartile 4; HRQ4-Q1: 0.29 [0.085–0.99]) and attenuated the association between leukopenia and all-cause mortality (P-interaction = 0.032). In brief, MedDiet decreased the incidence of white blood cell count-related alterations in high cardiovascular risk individuals.


Sign in / Sign up

Export Citation Format

Share Document