scholarly journals Moderate Carotid Artery Stenosis: MR Imaging-Depicted Intraplaque Hemorrhage Predicts Risk of Cerebrovascular Ischemic Events in Asymptomatic Men

2010 ◽  
Vol 51 (4) ◽  
pp. 1064
Author(s):  
N. Singh ◽  
A.R. Moody ◽  
B.J. Gladstone
Radiology ◽  
2009 ◽  
Vol 252 (2) ◽  
pp. 502-508 ◽  
Author(s):  
Navneet Singh ◽  
Alan R. Moody ◽  
David J. Gladstone ◽  
General Leung ◽  
Radhakrishnan Ravikumar ◽  
...  

2013 ◽  
Vol 57 (5) ◽  
pp. 26S-27S ◽  
Author(s):  
Stavros K. Kakkos ◽  
Ioanna Charalambous ◽  
Michael M. Sabetai ◽  
Maura B. Griffin ◽  
Niki Georgiou ◽  
...  

2009 ◽  
Vol 31 (3) ◽  
pp. 487-493 ◽  
Author(s):  
H.R. Underhill ◽  
C. Yuan ◽  
V.L. Yarnykh ◽  
B. Chu ◽  
M. Oikawa ◽  
...  

2016 ◽  
Vol 89 ◽  
pp. 611-619 ◽  
Author(s):  
Xiaoming Rong ◽  
Wuyang Yang ◽  
Tomas Garzon-Muvdi ◽  
Xiaobu Ye ◽  
Justin M. Caplan ◽  
...  

Neurosurgery ◽  
2015 ◽  
Vol 76 (4) ◽  
pp. 427-434 ◽  
Author(s):  
Daina Kashiwazaki ◽  
Naoki Akioka ◽  
Naoya Kuwayama ◽  
Kyo Noguchi ◽  
Kortaro Tanaka ◽  
...  

Abstract BACKGROUND: The mechanisms underlying acute cerebrovascular syndrome in patients with carotid artery stenosis remain unclear. OBJECTIVE: To assess the relationships among infarct localization, hemodynamics, and plaque components. METHODS: This prospective study included 38 patients with acute cerebrovascular syndrome resulting from ipsilateral carotid artery stenosis. Cerebral infarct localization was categorized into 3 patterns (cortical, border zone, and mixed pattern). Carotid plaque components were evaluated with T1-weighted magnetic resonance imaging and time-of-flight imaging. Cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) were also quantified. RESULTS: Infarcts were identified in 38 patients with the use of diffusion-weighted magnetic resonance imaging. On the basis of the assessment of hemodynamics, the cortical pattern was seen in 18 of 21 patients with type 1 ischemia (normal CBF, normal CVR), whereas the mixed pattern was seen in 2 patients with type 2 ischemia (normal CBF, impaired CVR) and 12 of 15 patients with type 3 ischemia (impaired CBF, impaired CVR). The plaque components were categorized into fibrous (4 patients), lipid-rich (14 patients), and intraplaque hemorrhage (IPH; 20 patients). Of the patients with fibrous plaque, 2 had border-zone and 2 had mixed-pattern infarcts. Of the patients with lipid-rich plaque, 7 had cortical and 6 had mixed-pattern infarcts. Of patients with intraplaque hemorrhage, 11 had cortical and 9 had mixed-pattern infarcts. CONCLUSION: Cortical infarction occurs as a result of vulnerable plaque. Reduced cerebral perfusion induces border-zone infarction. Both factors are implicated in mixed-pattern infarction. Developments in noninvasive diagnostic modalities allow us to explore the mechanisms behind acute cerebrovascular syndrome in carotid artery stenosis and to determine the ideal therapies.


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