scholarly journals Albuminuria and Serum Creatinine in Predicting Renal Function Decline in Patients with Diabetic Nephropathy: A Systematic Literature Review

2016 ◽  
Vol 19 (7) ◽  
pp. A520 ◽  
Author(s):  
E Grubb ◽  
J Van der Vaart ◽  
K Norris ◽  
KE Smoyer ◽  
C Rolland
Keyword(s):  
Renal Function ◽  
Diabetic Nephropathy ◽  
Literature Review ◽  
Serum Creatinine ◽  
Systematic Literature Review ◽  
Renal Function Decline

scholarly journals Effect of Renamezin upon attenuation of renal function decline in pre-dialysis chronic kidney disease patients: 24-week prospective observational cohort study

PLoS ONE ◽  
2021 ◽  
Vol 16 (6) ◽  
pp. e0252186
Author(s):  
Hayne Cho Park ◽  
AJin Cho ◽  
Do Hyoung Kim ◽  
Kyu-sang Yun ◽  
Juhee Kim ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Cohort Study ◽  
Kidney Disease ◽  
Adverse Events ◽  
Serum Creatinine ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
Renal Function Decline ◽  
Observational Cohort

Renamezin® is a modified capsule-type oral spherical adsorptive carbon which lowers indoxyl sulfate levels in patients with advanced chronic kidney disease (CKD). This 24-week prospective observational cohort study was performed to evaluate the effect of Renamezin® upon attenuation of renal function decline. A total of 1,149 adult patients with baseline serum creatinine 2.0–5.0 mg/dL were enrolled from 22 tertiary hospital in Korea from April 2016 to September 2018. Among them, a total of 686 patients completed the study and were included in the intention-to-treat analysis. A total of 1,061 patients were included in the safety analysis. The mean age was 63.5 years and male patients were predominant (63.6%). Most of the patients (76.8%) demonstrated high compliance with study drug (6g per day). After 24 week of treatment, serum creatinine was increased from 2.86±0.72 mg/dL to 3.06±1.15 mg/dL (p<0.001), but estimated glomerular filtration rate was not changed significantly during observation period (22.3±6.8 mL/min/1.73m2 to 22.1±9.1 mL/min/1.73m2, p = 0.243). Patients with age over 65 years old and those under good systolic blood pressure control <130 mmHg were most likely to get benefit from Renamezin® treatment to preserve renal function. A total of 98 (9.2%) patients out of 1,061 safety population experienced 134 adverse events, of which gastrointestinal disorders were the most common. There were no serious treatment-related adverse events. Renamezin® can be used safely to attenuate renal function decline in moderately advanced CKD patients.

FP370THE RELATIONSHIP BETWEEN RENAL FUNCTION AND OUTCOMES IN PATIENTS WITH CHRONIC KIDNEY DISEASE: A SYSTEMATIC LITERATURE REVIEW

2019 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Daniel Sugrue ◽  
Heleen Van Haalen ◽  
Juan Jose Garcia Sanchez ◽  
Oliver Darlington ◽  
Phil Mcewan
Keyword(s):  
Chronic Kidney Disease ◽  
Renal Function ◽  
Kidney Disease ◽  
Literature Review ◽  
Systematic Literature Review

Treatment of Gout Patients with Impairment of Renal Function: A Systematic Literature Review

2014 ◽  
Vol 92 (0) ◽  
pp. 48-54 ◽  
Author(s):  
I. A. van Echteld ◽  
C. van Durme ◽  
L. Falzon ◽  
R. B. Landewe ◽  
D. M. van der Heijde ◽  
...  
Keyword(s):  
Renal Function ◽  
Literature Review ◽  
Systematic Literature Review

scholarly journals Renal histology in diabetic nephropathy predicts progression to end-stage kidney disease but not the rate of renal function decline

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Paraish S. Misra ◽  
Stephen G. Szeto ◽  
Adriana Krizova ◽  
Richard E. Gilbert ◽  
Darren A. Yuen
Keyword(s):  
Renal Function ◽  
Diabetic Nephropathy ◽  
Kidney Disease ◽  
End Stage Kidney Disease ◽  
Renal Function Decline ◽  
Renal Histology ◽  
End Stage

scholarly journals The association between fast-food consumption with cardiovascular diseases risk factors and kidney function in patients with diabetic nephropathy

2021 ◽  
Vol 13 (3) ◽  
pp. 241-249
Author(s):  
Seyyed Reza Sobhani ◽  
Mojgan Mortazavi ◽  
Mahsa Kazemifar ◽  
Leila Azadbakht
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Renal Function ◽  
Diabetic Nephropathy ◽  
Serum Creatinine ◽  
Lipid Profile ◽  
Food Consumption ◽  
Fast Food ◽  
Fast Food Consumption ◽  
Hs Crp

Introduction: Fast food consumption (FFC) has been raised as a risk factor for cardiometabolic outcomes and renal function disorders. The present study aimed to investigate the association between FFC and cardiovascular disease (CVD) risk factors and renal function among patients with diabetic nephropathy (DN). Methods: This cross-sectional study was conducted among 397 randomly enrolled patients with DN. A validated 168 food items food frequency questionnaire was used for measuring FFC. Weight, waist,height, fasting blood sugar (FBS), hemoglobin A1C (HbA1C), serum creatinine, blood urea nitrogen(BUN), hs-CRP, systolic blood pressure(SBP), diastolic blood pressure (DBP), and lipid profile concentrations were measured. Generalized linear model analysis of covariance was used to compare means of BP, biochemical and anthropometric factors across tertiles of FFC adjusted for potential confounders. Results: The mean weekly intakes of fast food were 130 ± 60 grams. Patients in the highest compared to the lowest tertiles of FFC were more likely to be overweight and obese, had higher levels of creatinine, SBP, and DBP in the unadjusted model (P<0.05). In the adjusted models, DN patients in the highest vs lowest tertiles of FFC had higher levels of SBP and DBP (P=<0.001). Conclusion: Higher consumption of fast food is associated with higher levels of both systolic and diastolic blood pressure in DN patients. The present study observed no significant differences between the highest versus the lowest tertiles of FFC for waist, FBS, HbA1C, serum creatinine, BUN, hs-CRP, and lipid profile concentrations.

Tissue expression of tubular injury markers is associated with renal function decline in diabetic nephropathy

2017 ◽  
Vol 31 (12) ◽  
pp. 1704-1709 ◽  
Author(s):  
Subin Hwang ◽  
Jeeeun Park ◽  
Jinhae Kim ◽  
Hye Ryoun Jang ◽  
Ghee Young Kwon ◽  
...  
Keyword(s):  
Renal Function ◽  
Diabetic Nephropathy ◽  
Tissue Expression ◽  
Tubular Injury ◽  
Renal Function Decline

scholarly journals Acute kidney injury strongly influences renal function after radical nephroureterectomy for upper tract urothelial carcinoma: A single-centre experience

2021 ◽  
Vol 93 (1) ◽  
pp. 9-14
Author(s):  
Alessandro Tafuri ◽  
Katia Odorizzi ◽  
Giacomo Di Filippo ◽  
Clara Cerrato ◽  
Giulia Fassio ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Renal Function ◽  
Multivariate Analysis ◽  
Serum Creatinine ◽  
Urothelial Carcinoma ◽  
Clinical Evaluation ◽  
Kidney Injury ◽  
Radical Nephroureterectomy ◽  
Clinical Factors ◽  
Renal Function Decline

Objective: The aim of our study was to investigate frequency and predictors both of postoperative acute kidney injury (AKI) and renal function decline in a population of consecutive upper tract urothelial carcinoma (UTUC) patients who underwent radical nephroureterectomy (RNU). Materials and methods: Between October 2014 and February 2020, 93 patients underwent RNU at our Institution. After considered exclusion criteria, 89 patients were selected. Perioperative clinical factors were retrospectively collected. Estimated glomerular filtration rate (eGFR) was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) equation. We defined AKI as an increase in serum creatinine by ≥ 0.3 mg/dl or a 1.5-1.9-fold increase in serum creatinine from baseline to I post-operative day (POD). A significant renal function reduction was defined as an eGFR reduction of 40% from baseline at discharge and at last clinical evaluation. Frequency of AKI and eGFR decline was investigated. Association between perioperative clinical factors and AKI and eGFR reduction at discharged and last follow-up was studied using univariate and multivariate models. Results: AKI was detected at I POD in 45 patients. On multivariate analysis, pre-operative eGFR was an independent predictor of AKI (OR 1.03; p = 0.042). Further, AKI was found to be a significant predictor of eGFR reduction ≥ 40% at discharge at univariate analysis (OR 19.42; p = 0.005) and at multivariate analysis (OR 12.49; p = 0.02). In a multivariate logistic regression model post-operative AKI (OR 5.18; p = 0.033), lack of ipsilateral preoperative hydronephrosis (OR 0.17; p = 0.016), preoperative eGFR (OR 1.04; p = 0.047) and antiplatelet therapy (OR 5.14; p = 0.018) were found to be independent predictors of an eGFR reduction higher than 40% at last clinical evaluation made at a median of 15 (IQR 5-30) months. Conclusions: In our cohort, AKI was present in almost 50% of patients after RNU and it was a strong predictor of renal function decline after RNU.

scholarly journals Methods to evaluate renal function in elderly patients: a systematic literature review

2010 ◽  
Vol 39 (5) ◽  
pp. 542-548 ◽  
Author(s):  
G. Van Pottelbergh ◽  
L. Van Heden ◽  
C. Mathei ◽  
J. Degryse
Keyword(s):  
Renal Function ◽  
Literature Review ◽  
Elderly Patients ◽  
Systematic Literature Review
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