scholarly journals Imi Get Real Work Package 1 Case Study: Challenges In Measuring Clinical Effectiveness In Copd And Potential Use Of Real-World Evidence To Reduce Uncertainty

2016 ◽  
Vol 19 (3) ◽  
pp. A121-A122
Author(s):  
A Jaksa ◽  
B Adler ◽  
J Rubinstein ◽  
H Birch ◽  
R Tomlinson ◽  
...  
Keyword(s):  
Real World ◽  
Clinical Effectiveness ◽  
Work Package ◽  
Real World Evidence ◽  
Real Work ◽  
Potential Use

scholarly journals Development of an Innovative Real-World Evidence Registry for the Herpes Simplex Virus: Case Study

10.2196/16933 ◽  
2020 ◽  
Vol 3 (1) ◽  
pp. e16933 ◽  
Author(s):  
Michelle Helena van Velthoven ◽  
Ching Lam ◽  
Caroline de Cock ◽  
Terese Stenfors ◽  
Hassan Chaudhury ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Real World ◽  
Physical Symptoms ◽  
Use Cases ◽  
Real World Data ◽  
World Data ◽  
Real World Evidence ◽  
Simplex Virus

Background Infection with the herpes simplex virus (HSV) is common but not well understood. Furthermore, there remains a social stigma surrounding HSV that can have psychosocial implications for those infected. Despite many patients infected with HSV experiencing mild-to-severe physical symptoms, only one subeffective treatment is available. A registry collecting real-world data reported by individuals potentially infected with HSV could help patients to better understand and manage their condition. Objective This study aimed to report on the development of a registry to collect real-world data reported by people who might be infected with HSV. Methods A case study design was selected as it provides a systematic and in-depth approach to investigating the planning phase of the registry. The case study followed seven stages: plan, design, prepare, collect, analyze, create, and share. We carried out semistructured interviews with experts, which were thematically analyzed and used to build use cases for the proposed registry. These use cases will be used to generate detailed models of how a real-world evidence registry might be perceived and used by different users. Results The following key themes were identified in the interviews: (1) stigma and anonymity, (2) selection bias, (3) understanding treatment and outcome gaps, (4) lifestyle factors, (5) individualized versus population-level data, and (6) severe complications of HSV. We developed use cases for different types of users of the registry, including individuals with HSV, members of the public, researchers, and clinicians. Conclusions This case study revealed key considerations and insights for the development of an appropriate registry to collect real-world data reported by people who might be infected with HSV. Further development and testing of the registry with different users is required. The registry must also be evaluated for the feasibility and effectiveness of collecting data to support symptom management. This registry has the potential to contribute to the development of vaccines and treatments and provide insights into the impact of HSV on other conditions.

scholarly journals Evaluation of Methods for the Inclusion of Real World Evidence in Network Meta-Analysis – A Case Study in Multiple Sclerosis

2014 ◽  
Vol 17 (7) ◽  
pp. A576 ◽  
Author(s):  
D. Jenkins ◽  
M. Czachorowski ◽  
S. Bujkiewicz ◽  
P. Dequen ◽  
P. Jonsson ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Real World ◽  
Meta Analysis ◽  
Real World Evidence ◽  
Evaluation Of Methods

scholarly journals The Role of Real-World Evidence in UK Reimbursement: Case Study of Lenalidomide in Myelodysplastic Syndrome Deletion 5q

2018 ◽  
Vol 3 (3) ◽  
pp. 351-358 ◽  
Author(s):  
Dawn Lee ◽  
Nic Brereton ◽  
Sujith Dhanasiri ◽  
Austin Kulasekararaj
Keyword(s):  
Myelodysplastic Syndrome ◽  
Real World ◽  
Real World Evidence
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