Skin Whitening Multiple Emulsions Loaded with Green Tea and Lotus Extracts: an Efficacy Study

T Mahmood; N Akhtar

doi:10.1016/j.jval.2015.09.1007

Fabrication, physicochemical characterization and preliminary efficacy evaluation of a W/O/W multiple emulsion loaded with 5% green tea extract

Brazilian Journal of Pharmaceutical Sciences ◽

10.1590/s1984-82502013000200016 ◽

2013 ◽

Vol 49 (2) ◽

pp. 341-349 ◽

Cited By ~ 7

Author(s):

Tariq Mahmood ◽

Naveed Akhtar ◽

Barkat Ali Khan ◽

Akhtar Rasul ◽

Haji M. Shoaib Khan

Keyword(s):

Green Tea ◽

Storage Conditions ◽

Green Tea Extract ◽

Viscosity Data ◽

Skin Protection ◽

Multiple Emulsion ◽

Multiple Emulsions ◽

Tea Extract

Complex multiple emulsions have an excellent ability to fill large volumes of functional cosmetic agents. This study was aimed to encapsulate large volume of green tea in classical multiple emulsion and to compare its stability with a multiple emulsion without green tea extract. Multiple emulsions were developed using Cetyl dimethicone copolyol as lipophilic emulsifier and classic polysorbate-80 as hydrophilic emulsifier. Multiple emulsions were evaluated for various physicochemical aspects like conductivity, pH, microscopic analysis, rheology and these characteristics were followed for a period of 30 days in different storage conditions. In vitro and in vivo skin protection tests were also performed for both kinds of multiple emulsions i.e. with active (MeA) and without active (MeB). Both formulations showed comparable characteristics regarding various physicochemical characteristics in different storage conditions. Rheological analysis showed that formulations showed pseudo plastic behavior upon continuous shear stress. Results of in vitro and in vivo skin protection data have revealed that the active formulation has comparable skin protection effects to that of control formulation. It was presumed that stable multiple emulsions could be a promising choice for topical application of green tea but multiple emulsions presented in this study need improvement in the formula, concluded on the basis of pH, conductivity and apparent viscosity data.

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Effect of Green Tea Seed Extract on the Skin Whitening Activity

10.21483/qwoaud.53..202109.77 ◽

2021 ◽

Vol 53 ◽

pp. 77-100

Author(s):

Myung-ja Lee ◽

Dubok Choi ◽

Hee-kyung Lee

Keyword(s):

Green Tea ◽

Seed Extract ◽

Skin Whitening ◽

Whitening Activity

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FORMULATION AND PHYSICAL EVALUATION OF MICROEMULSION AND W/O/W MULTIPLE EMULSIONS DOSAGE FORMS WITH ALPHA ARBUTIN, LACTIC ACID, AND NIACINAMIDE AS SKIN-WHITENING COSMETICS

International Journal of Applied Pharmaceutics ◽

10.22159/ijap.2017.v9s1.39_45 ◽

2017 ◽

Vol 9 ◽

pp. 67 ◽

Cited By ~ 1

Author(s):

Silvia Surini ◽

Tina Mellani

Keyword(s):

Lactic Acid ◽

Stable Distribution ◽

Physical Stability ◽

Tween 80 ◽

Dosage Forms ◽

Distribution Profile ◽

Skin Whitening ◽

Multiple Emulsions ◽

Globule Size ◽

Skin Lightening

Objective: The present study aimed to formulate and determine the physical stability of microemulsion and W/O/W multiple emulsions, containingα arbutin, lactic acid, and niacinamide, as skin-whitening cosmetics.Methods: A skin lightening effect can also be obtained from lactic acid, which accelerates the turnover of pigmented cells in the epidermis, andfrom niacinamide, which inhibits the transfer of melanosomes from melanocytes to keratinocytes. These active ingredients were combined inmicroemulsion and W/O/W multiple emulsions dosage forms in various concentrations of Tween 80 as an emulsifier. An evaluation and physicalstability test were carried out during 12 weeks of storage at 28±2°C, 4±2°C, and 40±2°C, as well as a cycling test.Results: The results showed that a microemulsion could be prepared in 25-35% of Tween 80 (surfactant) and 10% of ethanol (co-surfactant), andthat it had globule sizes of 2.397-16.8 nm, a transparent, pseudoplastic flow, and was most stable in storage at 28±2°C. Microemulsion with 35% ofTween 80 was the most stable microemulsion formula because it had the smallest globule size, the most stable distribution profiles of globule sizes,and the highest viscosity. W/O/W multiple emulsions could formulated made with 2.5-4.5% of Tween 80 (external emulsifier) and 3% of Span 80(internal emulsifier); these emulsions had a pseudoplastic-thixotropic flow and were most stable in storage at 28±2°C.Conclusions: The formulation of multiple emulsions with 2.5% of Tween 80 was the most stable formula, with a stable distribution profile of globulesizes during 8 weeks of storage at temperatures of 28±2°C, 4±2°C, and 40±2°C.

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Physiological Activity of Irradiated Green Tea Polyphenol on the Human Skin

The American Journal of Chinese Medicine ◽

10.1142/s0192415x05003144 ◽

2005 ◽

Vol 33 (04) ◽

pp. 535-546 ◽

Cited By ~ 18

Author(s):

Bong-Jeun An ◽

Jae-Hoon Kwak ◽

Jun-Ho Son ◽

Jung-Mi Park ◽

Jin-Young Lee ◽

...

Keyword(s):

Human Skin ◽

Green Tea ◽

Physiological Activity ◽

Food Composition ◽

Tea Polyphenol ◽

Skin Whitening ◽

Inhibition Effect ◽

Anticancer Effects ◽

Green Tea Polyphenol ◽

Collagenase Inhibition

Physiological activity of irradiated green tea polyphenol on the human skin was investigated for further industrial application. The green tea polyphenol was separated and irradiated at 40 kGy by γ-ray. For an anti-wrinkle effect, the collagenase inhibition effect was higher in the irradiated sample (65.3%) than that of the non-irradiated control (56.8%) at 200 ppm of the concentration ( p < 0.05). Collagen biosynthesis rats using a human fibroblast were 19.4% and 16.3% in the irradiated and the non-irradiated polyphenols, respectively. The tyrosinase inhibition effect, which is related to the skin-whitening effect, showed a 45.2% and 42.9% in the irradiated and the non-irradiated polyphenols, respectively, at a 100 ppm level. A higher than 90% growth inhibition on skin cancer cells (SK-MEL-2 and G361) was demonstrated in both the irradiated and the non-irradiated polyphenols. Thus, the irradiation of green tea polyphenol did not change and even increased its anti-wrinkle, skin-whitening and anticancer effects on the human skin. The results indicated that irradiated green tea polyphenol can be used as a natural ingredient with excellent physiological functions for the human skin through cosmetic or food composition.

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