scholarly journals RU2 Potential Time Savings With Trastuzumab Subcutaneous (SC) Injection Versus Trastuzumab Intravenous (IV) Infusion: Results from Interviews Conducted As Part of a Time-and-Motion Study (T&M) Across 17 Sites

2012 ◽  
Vol 15 (7) ◽  
pp. A280 ◽  
Author(s):  
E. De Cock ◽  
S. Tao ◽  
A. Urspruch ◽  
A. Knoop
Keyword(s):  
Time And Motion Study ◽  
Time And Motion ◽  
Motion Study ◽  
Time Savings

scholarly journals Time Savings with Once-Monthly C.E.R.A.: A Time and Motion Study Conducted in 13 Haemodialysis Centres in Italy

2015 ◽  
Vol 40 (2) ◽  
pp. 173-179 ◽  
Author(s):  
Erwin De Cock ◽  
Persefoni Kritikou ◽  
Simona Ravera ◽  
Armando Filippini
Keyword(s):  
Health Care Professionals ◽  
Renal Anaemia ◽  
Time And Motion Study ◽  
Time And Motion ◽  
Motion Study ◽  
Receptor Activator ◽  
Anaemia Management ◽  
Time Savings ◽  
Time Required ◽  
Annual Time

Background: We sought to document the time required by health care professionals to administer erythropoiesis-stimulating agents (ESAs) and continuous erythropoiesis receptor activator (C.E.R.A.) in the management of renal anaemia. Methods: A Time and Motion study was conducted in 13 centres in Italy. The time spent on preparation, distribution, and injection for both ESA and C.E.R.A. groups was measured. A multilevel model was run to account for the centre-clustering effect. Results: The average number of ESA injections/patient/year was 89. The average uptake of C.E.R.A. was 26%. The average time per session was 1.54 min for ESA (95% CI 1.21-1.86) vs. 1.64 min for C.E.R.A. (95% CI 1.31-1.97). Estimated time/patient/year was 137 min for ESA and 20 min for C.E.R.A. Assuming a 100% uptake of C.E.R.A., annual time savings/centre would be 84% (194 h). Conclusions: Substantial annual time savings on frequent anaemia management-related tasks were found when a switchover was made from ESAs to C.E.R.A.

Time Savings With Rituximab Subcutaneous (SC) Injection Vs Rituximab Intravenous (IV) Infusion: Final Analysis From a Time-and-Motion Study In 8 Countries

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 1724-1724 ◽  
Author(s):  
Erwin De Cock ◽  
Persefoni Kritikou ◽  
Sunning Tao ◽  
Christof Wiesner ◽  
Tim Waterboer ◽  
...  
Keyword(s):  
Research Funding ◽  
Cost Savings ◽  
Hodgkin's Lymphoma ◽  
First Year ◽  
Time And Motion Study ◽  
Time And Motion ◽  
Motion Study ◽  
The Mean ◽  
Time Savings ◽  
The Uk

Abstract Background Rituximab (MabThera®; Rituxan®) is the standard treatment for indolent non-Hodgkin's lymphoma (iNHL). Results from the phase 3 SABRINA study (NCT01200758) showed that a fixed-dose subcutaneous (SC) formulation of rituximab shortened administration time without compromising efficacy or safety compared with intravenous (IV) infusion of rituximab. A switch to the SC formulation is expected to offer healthcare professionals (HCP) time and cost savings. Aims This study aims to quantify resource utilization in terms of active HCP time (ie, time actively dedicated to a patient) and chair time related to rituximab SC vs rituximab IV in the treatment of patients with iNHL and to estimate potential time and cost savings for the conversion from IV to SC (per administration session and for the first year of treatment). Methods This is a multinational, multicenter, prospective, observational time and motion study. Data for rituximab SC injections were collected alongside the MABCUTE (MO25455; NCT01461928) trial, while data for rituximab IV infusions were collected in a real-world setting in the same data collection period and in 23 centers in Italy (IT), Russia (RU), Slovenia (SL), United Kingdom (UK), Spain (SP), France (FR), Austria (AU), and Brazil (BR). Following interviews with a nurse and pharmacy member in each center, generic case report forms for IV, SC, and drug preparation area (including pharmacy) processes were tailored to reflect local site practices. Trained observers recorded both the time that HCPs were actively completing prespecified tasks (using a stopwatch), and patient chair time (based on length of time between patients entering and exiting chairs). This is a descriptive study with convenience-based sample sizes. A random effects regression model was run for each task (pooled sample by country) to generate task mean and 95% confidence interval (CI) using appropriate distributions. IV vs SC process time per patient was calculated as the sum of the mean task times. Results The difference in mean active HCP time saved by switching from rituximab IV to rituximab SC ranged from 6.8 min in AU to 38.4 min in the UK (Table 1). The proportionate reduction in mean HCP time ranged from 27% in SP to 57% in RU. The mean time saved (% reduction) in the treatment room ranged from 0.3 min (2%) in SP to 25.4 min (63%) in the UK. Over the course of the first-year of treatment (6 induction and 3 maintenance sessions), the estimated reduction in total HCP time associated with the switch ranged from 0.9 hr in AU to 5.1 hr in the UK. The differences in mean chair time saved with SC over IV administration ranged from 126.1 min in SL (64%) to 280.1 min (86%) in IT. Simulating these findings for a hypothetical center treating 50 patients for 9 sessions annually indicated that the amount of chair time freed would range from 105.1 (SL) to 233.4 (IT) 8-hour days. Staff opportunity cost estimates will be presented at the conference. Conclusions The current analysis indicates that a switch from rituximab IV to rituximab SC leads to a substantial reduction in administration chair time and in active HCP time. These time savings could allow more time to be used for other patient care activities, increasing the number of patients who could be treated and thus increasing the overall efficiency of treatment centers. Disclosures: De Cock: F. Hoffman-La Roche Ltd: Consultancy, Research Funding. Kritikou:F. Hoffmann-La Roche Ltd: Consultancy, Research Funding. Tao:F. Hoffmann-La Roche Ltd: Consultancy, Research Funding. Wiesner:Genentech: Employment. Off Label Use: Rituximab, administered as an IV infusion, is approved for use in a number of hematologic indications. The data presented here assess a subcutaneous approach to rituximab administration in patients with indolent Non-Hodgkin’s Lymphoma.

scholarly journals Time Savings with Once-Monthly C.E.R.A.: A Time and Motion Study Conducted in 13 Hemodialysis Centres in Italy

2013 ◽  
Vol 16 (7) ◽  
pp. A636
Author(s):  
E. De Cock ◽  
P. Kritikou ◽  
I. Proskorovsky ◽  
R. Tomic
Keyword(s):  
Time And Motion Study ◽  
Time And Motion ◽  
Motion Study ◽  
Time Savings

Time savings associated with C.E.R.A. once monthly: a time-and-motion study in hemodialysis centers in five European countries

2013 ◽  
Vol 16 (5) ◽  
pp. 648-656 ◽  
Author(s):  
Erwin De Cock ◽  
Frank Dellanna ◽  
Karim Khellaf ◽  
Wieslaw Klatko ◽  
Francisco Maduell ◽  
...  
Keyword(s):  
European Countries ◽  
Time And Motion Study ◽  
Time And Motion ◽  
Motion Study ◽  
Time Savings

scholarly journals Time Savings with Rituximab Subcutaneous Injection versus Rituximab Intravenous Infusion: A Time and Motion Study in Eight Countries

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0157957 ◽  
Author(s):  
Erwin De Cock ◽  
Persefoni Kritikou ◽  
Mariana Sandoval ◽  
Sunning Tao ◽  
Christof Wiesner ◽  
...  
Keyword(s):  
Intravenous Infusion ◽  
Subcutaneous Injection ◽  
Time And Motion Study ◽  
Time And Motion ◽  
Motion Study ◽  
Time Savings

Discussion on “Time and motion study” at the Yorkshire Section of the Institution

1937 ◽  
Vol 16 (11) ◽  
pp. 609
Author(s):  
A. Sykes ◽  
Hall ◽  
George Hepworth ◽  
F. Grover ◽  
E. Drake ◽  
...  
Keyword(s):  
Time And Motion Study ◽  
Time And Motion ◽  
Motion Study
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