scholarly journals MP79-08 INTRAOPERATIVE FLUORESCENCE IMAGING WITH INDOCYANINE GREEN FOR SENTINEL LYMPH NODES FOR PROSTATE CANCER DURING LAPAROSCOPIC RADICAL PROSTATECTOMY

2016 ◽  
Vol 195 (4S) ◽  
Author(s):  
JUN MIKI ◽  
Takafumi Yanagisawa ◽  
Fumihiko Urabe ◽  
Keiji Yasue ◽  
Taro Igarashi ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Lymph Nodes ◽  
Indocyanine Green ◽  
Fluorescence Imaging ◽  
Sentinel Lymph Nodes ◽  
Laparoscopic Radical Prostatectomy ◽  
Intraoperative Fluorescence Imaging ◽  
Intraoperative Fluorescence

scholarly journals Intraoperative fluorescence imaging to localize tumors and sentinel lymph nodes in rectal cancer

2015 ◽  
Vol 25 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Henricus J.M. Handgraaf ◽  
Leonora S.F. Boogerd ◽  
Floris P.R. Verbeek ◽  
Quirijn R.J.G. Tummers ◽  
James C.H. Hardwick ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Nodes ◽  
Fluorescence Imaging ◽  
Sentinel Lymph Nodes ◽  
Intraoperative Fluorescence Imaging ◽  
Intraoperative Fluorescence

scholarly journals Systemic Sentinel Lymph Node Detection Using Fluorescence Imaging After Indocyanine Green Intravenous Injection in Colorectal Cancer: Protocol for a Feasibility Study

10.2196/17976 ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. e17976 ◽  
Author(s):  
Gabriel Liberale ◽  
Sophie Vankerckhove ◽  
Fikri Bouazza ◽  
Maria Gomez Galdon ◽  
Denis Larsimont ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Nodes ◽  
Indocyanine Green ◽  
Fluorescence Imaging ◽  
Sentinel Lymph Nodes ◽  
Nodal Staging ◽  
Sentinel Lymph Node Detection ◽  
Indocyanine Green Dye

Background Nodal staging is a major concern in colorectal cancer as it is an important prognostic factor. Several techniques that could potentially improve patient treatment and prognosis have been developed to increase the accuracy of nodal staging. Sentinel lymph node detection has been shown to accurately reflect nodal status in various tumors and has become the standard procedure in nodal staging of breast cancer and melanoma. However, in colorectal cancer, sentinel lymph node detection techniques are still controversial as the sensitivity reported in the literature varies from one study to another. Recently, indocyanine green fluorescence–guided surgery has been reported to be a useful technique for detection of macroscopic and microscopic metastatic deposits in lymph nodes after intravenous administration of indocyanine green dye. However, no studies have focused on the potential role of sentinel lymph node detection after systemic administration of indocyanine green dye, so-called systemic sentinel lymph nodes, or on the correspondence between the identification of the sentinel lymph node by standard local injection techniques and the detection of fluorescent lymph nodes with this new approach. Objective The aim of this protocol is to validate the concept of sentinel lymph nodes identified by fluorescence imaging after intravenous injection of indocyanine green dye and to compare the sentinel lymph nodes identified by fluorescence imaging with sentinel lymph nodes detected by the standard blue dye technique. Methods This study (SeLyNoFI; Sentinel Lymph Nodes Fluorescence Imaging) is a diagnostic, single-arm, open-label feasibility study, including patients with colorectal adenocarcinoma with or without metastatic disease who are admitted for elective colorectal resection of the primary tumor. This study evaluates the feasibility of a new approach for improving the accuracy of nodal staging using fluorescence imaging after intravenous administration of indocyanine green dye. Sensitivity, positive predictive value, and accuracy of the classical blue dye technique and of the investigatory fluorescence imaging technique will be calculated. Translational research will be proposed, if applicable. Results As of June 2020, this study has been registered. Submission for ethical review is planned for September 2020. Conclusions The potential correlation between the two different approaches to detect sentinel lymph nodes offers new strategies for improving the accuracy of nodal staging in colorectal cancer. This new concept of the systemic sentinel lymph node and a greater understanding of the interactions between systemic sentinel lymph nodes and standard sentinel lymph nodes may provide important information regarding the underlying mechanism of primary tumor lymphatic drainage. The enhanced permeability and retention effect can also play a role in the fluorescence of systemic sentinel lymph nodes, especially if these lymph nodes are inflamed. In this case, we can even imagine that this new technique will highlight more instances of lymph node–positive colorectal cancer. International Registered Report Identifier (IRRID) PRR1-10.2196/17976

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