1892 PT2 SUBSTAGING IN UROTHELIAL CARCINOMA OF THE BLADDER: DEEP MUSCLE INVASION IS ASSOCIATED WITH WORSE OUTCOME

2011 ◽  
Vol 185 (4S) ◽  
Author(s):  
Derya Tilki ◽  
Oliver Reich ◽  
Pierre Karakiewicz ◽  
Giacomo Novara ◽  
Wassim Kassouf ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Deep Muscle ◽  
Carcinoma Of The Bladder ◽  
Muscle Invasion

Superficial bladder cancer: the primacy of grade in the development of invasive disease.

1987 ◽  
Vol 5 (1) ◽  
pp. 125-130 ◽  
Author(s):  
F M Torti ◽  
B L Lum ◽  
D Aston ◽  
N MacKenzie ◽  
M Faysel ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Logistic Regression ◽  
Superficial Bladder Cancer ◽  
Medical Center ◽  
Bladder Wall ◽  
Transitional Cell ◽  
Invasive Disease ◽  
Deep Muscle ◽  
Carcinoma Of The Bladder ◽  
Muscle Invasion

Tumor characteristics thought to predict for development of deep muscle invasion after resection of superficial bladder cancer were retrospectively analyzed in 252 patients with transitional cell carcinoma of the bladder at Stanford University Medical Center. Stage 0 patients accounted for 190 of the patient population (75.5%), while stage A and B1 comprised 51 (20%) and 11 (4.5%), respectively. The median follow-up time was 62 months. Forty-three patients subsequently developed deep muscle invasion; these included 24 (12.6%), 14 (27.5%), and 5 (45.5%) of stage 0, A, and B1 patients (P = .002), or 15 (10%), 15 (9%), and 13 (33%) of grade 1, 2, and 3 tumors (P = .001), respectively. When analyzed by univariate logistic regression, grade (P = .0001) and stage (P = .0118) were significant predictors for invasive disease. Site of tumor and number of tumors at presentation were not significant factors for invasion deep into the bladder wall. When multiple logistic regression was performed, only grade remained as a significant tumor variable to predict for invasive disease (P less than .0091). Risk of invasive disease did not appear to increase with increasing number of recurrences, remaining at approximately an 11% invasion rate through 12 recurrences. In this analysis, grade was the most significant tumor variable in superficial bladder cancer predicting for the development of invasive carcinoma. Future clinical trials for definitive or adjuvant therapy of this disease must stratify for this variable.

scholarly journals Prognostic Implications of Deep Muscle Invasion and High Grade for Bladder Urothelial Carcinoma

Cureus ◽  
2020 ◽  
Author(s):  
Atif Ali Hashmi ◽  
Sana Rafique ◽  
Rimsha Haider ◽  
Shahzeb Munawar ◽  
Muhammad Irfan ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
High Grade ◽  
Bladder Urothelial Carcinoma ◽  
Deep Muscle ◽  
Prognostic Implications ◽  
Muscle Invasion

Incidentally Discovered Osseous Metaplasia Within High-grade Urothelial Carcinoma of the Bladder

Urology ◽  
2012 ◽  
Vol 79 (4) ◽  
pp. e59-e60 ◽  
Author(s):  
Anne G. Dudley ◽  
Jeffrey J. Tomaszewski ◽  
Amber H. Hughes ◽  
Benjamin J. Davies
Keyword(s):  
Urothelial Carcinoma ◽  
Osseous Metaplasia ◽  
High Grade ◽  
Carcinoma Of The Bladder

scholarly journals Rectal metastasis from bladder urothelial carcinoma: a case report

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yuki Ii ◽  
Shinya Munakata ◽  
Kumpei Honjo ◽  
Masaya Kawai ◽  
Shingo Kawano ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Tumor Resection ◽  
Disease Recurrence ◽  
Small Areas ◽  
Metastatic Urothelial Carcinoma ◽  
Rare Site ◽  
Difficult Defecation ◽  
Carcinoma Of The Bladder ◽  
Transitional Cells ◽  
Rectal Metastasis

Abstract Background Urothelial carcinoma arises from transitional cells in the urothelial tract. In advanced cases, it can metastasize locally to surrounding organs or distally to organs such as the lungs, bones, or liver. Here we describe a case of rectal metastasis from urothelial carcinoma treated with multiple sessions of transurethral resection of bladder tumor (TURBT). Case presentation A 72-year-old woman presented to our department with abdominal bloating andobstructed defecation. She had undergone two sessions of TURBT for early urothelial carcinoma in another hospital at 64 and 65 months ago, respectively. Cystoscopy at 3 months after the second TURBT session had indicated disease recurrence, and thus, she had been referred to our hospital for further examination, followed by TURBT for the third time at 59 months ago and for the fourth time at 48 months ago; thereafter, she had been followed up with cystoscopy every 6 months without any recurrence. However, she returned to our hospital, complaining of difficult defecation. Subsequent colonoscopy demonstrated an obstructive tumor in the rectum, which was pathologically diagnosed as metastatic urothelial carcinoma of the bladder. Laparoscopic examination revealed two small areas of peritoneal dissemination in the pelvis. A sigmoid colostomy was performed without rectal tumor resection. She has been receiving chemotherapy and is still alive 10 months after surgery. Conclusions Rectal metastasis is a rare site of metastasis for urothelial carcinomas. It is important to consider the possibility of annular rectal constriction caused by infiltrating or metastasizing urothelial carcinoma when managing patients with urothelial carcinoma and with difficult defecation.

MP65-11 MUCIN 16 IS A MUTATIONAL HOTSPOT FOR NON-MUSCLE INVASIVE UROTHELIAL CARCINOMA OF THE BLADDER

2017 ◽  
Vol 197 (4S) ◽  
Author(s):  
Sumeet Syan-Bhanvadia ◽  
Christopher Duymich ◽  
Yong June Kim ◽  
Jessica Charlet ◽  
Hung-Yoon Yoon ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Carcinoma Of The Bladder ◽  
Muscle Invasive
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