scholarly journals Individualized treatment strategies for patients with aortic valve disease and porcelain aorta

2015 ◽  
Vol 149 (1) ◽  
pp. 134-136 ◽  
Author(s):  
Scott A. LeMaire
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Disease ◽  
Treatment Strategies ◽  
Individualized Treatment ◽  
Valve Disease ◽  
Porcelain Aorta

scholarly journals Creation of disease-inspired biomaterial environments to mimic pathological events in early calcific aortic valve disease

2017 ◽  
Vol 115 (3) ◽  
pp. E363-E371 ◽  
Author(s):  
Ana M. Porras ◽  
Jennifer A. Westlund ◽  
Austin D. Evans ◽  
Kristyn S. Masters
Keyword(s):  
Aortic Valve ◽  
Disease Progression ◽  
Aortic Valve Disease ◽  
Low Density Lipoprotein ◽  
Treatment Strategies ◽  
Density Lipoprotein ◽  
Valve Disease ◽  
Calcific Aortic Valve Disease ◽  
Valve Lesion

An insufficient understanding of calcific aortic valve disease (CAVD) pathogenesis remains a major obstacle in developing treatment strategies for this disease. The aim of the present study was to create engineered environments that mimic the earliest known features of CAVD and apply this in vitro platform to decipher relationships relevant to early valve lesion pathobiology. Glycosaminoglycan (GAG) enrichment is a dominant hallmark of early CAVD, but culture of valvular interstitial cells (VICs) in biomaterial environments containing pathological amounts of hyaluronic acid (HA) or chondroitin sulfate (CS) did not directly increase indicators of disease progression such as VIC activation or inflammatory cytokine production. However, HA-enriched matrices increased production of vascular endothelial growth factor (VEGF), while matrices displaying pathological levels of CS were effective at retaining lipoproteins, whose deposition is also found in early CAVD. Retained oxidized low-density lipoprotein (oxLDL), in turn, stimulated myofibroblastic VIC differentiation and secretion of numerous inflammatory cytokines. OxLDL also increased VIC deposition of GAGs, thereby creating a positive feedback loop to further enrich GAG content and promote disease progression. Using this disease-inspired in vitro platform, we were able to model a complex, multistep pathological sequence, with our findings suggesting distinct roles for individual GAGs in outcomes related to valve lesion progression, as well as key differences in cell–lipoprotein interactions compared with atherosclerosis. We propose a pathogenesis cascade that may be relevant to understanding early CAVD and envision the extension of such models to investigate other tissue pathologies or test pharmacological treatments.

Treatment strategies for mixed aortic valve disease in nonelderly patients

2019 ◽  
Vol 17 (12) ◽  
pp. 873-882 ◽  
Author(s):  
Maria Von Stumm ◽  
J. Petersen ◽  
D. Westermann ◽  
Hermann Reichenspurner ◽  
Evaldas Girdauskas
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Disease ◽  
Treatment Strategies ◽  
Valve Disease

Radiotherapy-induced aortic valve disease associated with porcelain aorta

2004 ◽  
Vol 52 (7) ◽  
pp. 349-352 ◽  
Author(s):  
Kazuyuki Daitoku ◽  
Kozo Fukui ◽  
Ikkoh Ichinoseki ◽  
Mamoru Munakata ◽  
Shoichi Takahashi ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Disease ◽  
Valve Disease ◽  
Porcelain Aorta

Implementation of a Rapid Deployment Aortic Valve for Aortic Valve Disease

2016 ◽  
Vol 64 (S 01) ◽  
Author(s):  
R. Malik ◽  
M. Roosta-Azad ◽  
H. Bigdeli ◽  
A. Zandi ◽  
H. Holst ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Valve Disease ◽  
Valve Disease ◽  
Rapid Deployment
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