scholarly journals A novel approach to the surgical correction of scimitar syndrome

2007 ◽  
Vol 133 (2) ◽  
pp. 573-574 ◽  
Author(s):  
Tuan T. Lam ◽  
Brian L. Reemtsen ◽  
Vaughn A. Starnes ◽  
Winfield J. Wells
Keyword(s):  
Scimitar Syndrome ◽  
Surgical Correction ◽  
Novel Approach

scholarly journals Surgical correction for scimitar syndrome by right thoracotomy and direct anastomosis in children

2021 ◽  
Vol 5 (1) ◽  
pp. 46-51
Author(s):  
Wei Cheng ◽  
Zhiqiang Li ◽  
Yaobin Zhu ◽  
Nan Ding ◽  
Daole Yan ◽  
...  
Keyword(s):  
Scimitar Syndrome ◽  
Surgical Correction ◽  
Right Thoracotomy ◽  
Direct Anastomosis

Thoracoscopic treatment of left-to-right shunt in a child with scimitar syndrome

2017 ◽  
Vol 28 (1) ◽  
pp. 159-162 ◽  
Author(s):  
Zafer Dokumcu ◽  
Emre Divarci ◽  
Ata Erdener
Keyword(s):  
Rare Variant ◽  
Venous Drainage ◽  
Scimitar Syndrome ◽  
Surgical Correction ◽  
Arterial Supply ◽  
Lung Hypoplasia ◽  
Thoracoscopic Approach ◽  
First Case ◽  
Anomalous Pulmonary Venous Connection

AbstractScimitar syndrome represents a rare variant of partial anomalous pulmonary venous connection with right lung hypoplasia, dextrocardia, and concomitant airway-vessel abnormalities. Surgical correction is preferred in symptomatic patients or in patients with increased left-to-right shunt. In this report, the first case of scimitar syndrome with dual arterial supply and venous drainage to be treated with thoracoscopic approach is presented.

scholarly journals A Novel Approach to Facilitate an Ideal Surgical Correction of Congenital Lobar Emphysema by Using Neonatal Ultrathin Bronchoscopy-Guided Endo-Bronchial Block

Cureus ◽  
2021 ◽  
Author(s):  
Vishal V Bhende ◽  
Tanishq S Sharma ◽  
Hardil P Majmudar ◽  
Sohilkhan R Pathan ◽  
Amit Chitaliya ◽  
...  
Keyword(s):  
Surgical Correction ◽  
Congenital Lobar Emphysema ◽  
Novel Approach ◽  
Lobar Emphysema

Surgical correction of rare anomaly of scimitar syndrome with tetralogy of Fallot

2021 ◽  
Author(s):  
Yatin Arora ◽  
Tanushree Kar ◽  
Srikant Sharma ◽  
Velayoudam Devagourou
Keyword(s):  
Tetralogy Of Fallot ◽  
Scimitar Syndrome ◽  
Surgical Correction ◽  
Rare Anomaly

Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov
Keyword(s):  
Oxidative Stress ◽  
Head And Neck ◽  
Transcriptional Activation ◽  
Platinum Resistance ◽  
Mrna Levels ◽  
Strong Positive Correlation ◽  
Platinum Compounds ◽  
Copper Chelation ◽  
Novel Approach ◽  
Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

Collecting Words: A Clinical Example of a Morphology-Focused Orthographic Intervention

2020 ◽  
Vol 51 (3) ◽  
pp. 544-560 ◽  
Author(s):  
Kimberly A. Murphy ◽  
Emily A. Diehm
Keyword(s):  
Written Language ◽  
Morphological Knowledge ◽  
English Orthography ◽  
Word Level ◽  
Novel Approach ◽  
Language Pathology ◽  
The One ◽  
Critical Intervention ◽  
Reading And Spelling ◽  
Reading And Spelling Difficulties

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687

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