scholarly journals Experimental safety and efficacy evaluation of an extracorporeal pumpless artificial lung in providing respiratory support through the axillary vessels

2007 ◽  
Vol 133 (2) ◽  
pp. 339-345.e2 ◽  
Author(s):  
Manuela Iglesias ◽  
Philipp Jungebluth ◽  
Oriol Sibila ◽  
Ivete Aldabo ◽  
María Purificación Matute ◽  
...  
Keyword(s):  
Artificial Lung ◽  
Respiratory Support ◽  
Efficacy Evaluation ◽  
Safety And Efficacy

Safety and efficacy evaluation of the automatic stepwise recruitment manoeuvre in the neonatal population: An in‐vivo interventional study

2021 ◽  
Author(s):  
Clara Serrano Zueras ◽  
Verónica Guilló Moreno ◽  
Martín Santos González ◽  
Francisco Javier Gómez Nieto ◽  
Göran Hedenstierna ◽  
...  
Keyword(s):  
Recruitment Manoeuvre ◽  
Interventional Study ◽  
Efficacy Evaluation ◽  
Safety And Efficacy ◽  
Neonatal Population

The Safety and Efficacy Evaluation of Dexmedetomidine for Procedural Sedation and Postoperative Behaviors in Pediatric Populations: A Systematic Review and Meta-analysis

2021 ◽  
pp. 106002802110098
Author(s):  
Linguang Gan ◽  
Xiaohong Zhao ◽  
Xiangjian Chen
Keyword(s):  
Pediatric Population ◽  
Meta Analysis ◽  
Procedural Sedation ◽  
Cochrane Library ◽  
Control Group ◽  
High Dose ◽  
Efficacy Evaluation ◽  
Safety And Efficacy ◽  
Ovid Medline ◽  
Pediatric Populations

Background: This study systematically evaluated the safety and efficacy of dexmedetomidine for procedural sedation and postoperative behaviors in a pediatric population as well as whether the results met the information required to draw conclusions. Objective: To evaluate the safety and efficacy evaluation of dexmedetomidine for procedural sedation and postoperative behaviors in a pediatric population. Methods: PubMed, Cochrane library, Web of Science and Ovid MEDLINE were searched to obtain randomized controlled trials (RCTs) comparing dexmedetomidine with control medicine and comparing different doses of dexmedetomidine. Results: There were a total of 16 RCTs for a total of 3240 patients. Dexmedetomidine slowed down the heart rate (HR; mean difference: −13.27; 95% CI: −16.41 to 10.14; P < 0.001) and reduced postoperative delirium (risk ratio [RR]: 0.31; 95% CI: 0.20-0.50; P < 0.001), the number of pain patients (RR: 0.48; 95% CI: 0.30-0.75; P = 0.002), and desaturation (RR: 0.34; 95% CI: 0.13-0.89; P = 0.03) compared with the control group. The limitation was that it was difficult to determine the range of low- and high-dose dexmedetomidine. Conclusion and Relevance: Dexmedetomidine slowed down intraoperative HR within the normal range, which might reduce myocardial oxygen consumption. It reduced postoperative pain and postoperative complications: delirium and desaturation. Dexmedetomidine showed no dose-dependent increase in the procedural sedation time of pediatric patients. Clinically, dexmedetomidine can improve pediatric procedural sedation and postoperative behavior, and it can be considered as a related medicine for safety in pediatric surgery.

Safety and Efficacy Evaluation Using Nonhuman Primates

2012 ◽  
pp. 493-510 ◽  
Author(s):  
Donna J. Clemons ◽  
Vince Meador ◽  
Gerhard F. Weinbauer ◽  
G. Alex Wakefield
Keyword(s):  
Nonhuman Primates ◽  
Efficacy Evaluation ◽  
Safety And Efficacy

Safety and efficacy evaluation of investigational liver gene transfer for secretable GAA in the treatment of Pompe disease

2019 ◽  
Vol 126 (2) ◽  
pp. S24 ◽  
Author(s):  
Sean M. Armour ◽  
Jayme Nordin ◽  
Francesco Puzzo ◽  
Umut Cagin ◽  
Marco Crosariol ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Pompe Disease ◽  
Efficacy Evaluation ◽  
Safety And Efficacy ◽  
Liver Gene

scholarly journals Temporary Disruption of the Blood–Brain Barrier by Use of Ultrasound and Microbubbles: Safety and Efficacy Evaluation in Rhesus Macaques

2012 ◽  
Vol 72 (14) ◽  
pp. 3652-3663 ◽  
Author(s):  
Nathan McDannold ◽  
Costas D. Arvanitis ◽  
Natalia Vykhodtseva ◽  
Margaret S. Livingstone
Keyword(s):  
Blood Brain Barrier ◽  
Rhesus Macaques ◽  
Brain Barrier ◽  
Efficacy Evaluation ◽  
Safety And Efficacy ◽  
Blood Brain
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