Use of Pre-Operative Tc99m-Sestamibi Scintigraphy and Intraoperative Parathyroid Hormone Monitoring to Eliminate Neck Exploration in Mediastinal Parathyroid Adenocarcinoma

2007 ◽  
Vol 64 (2) ◽  
pp. 108-112 ◽  
Author(s):  
Amir Damadi ◽  
James Harkema ◽  
Rao Kareti ◽  
Andrew Saxe
Keyword(s):  
Parathyroid Hormone ◽  
Neck Exploration ◽  
Sestamibi Scintigraphy ◽  
Parathyroid Hormone Monitoring ◽  
Intraoperative Parathyroid Hormone ◽  
Mediastinal Parathyroid

Does Rapid Intraoperative Parathyroid Hormone Analysis Predict Cure in Patients Undergoing Surgery for Primary Hyperparathyroidism?

2006 ◽  
Vol 95 (1) ◽  
pp. 28-32 ◽  
Author(s):  
F. S. Nilsen ◽  
E. Haug ◽  
M. Heidemann ◽  
S. J. Karlsen
Keyword(s):  
Parathyroid Hormone ◽  
False Negative ◽  
Parathyroid Tissue ◽  
Neck Surgery ◽  
Anatomical Location ◽  
Negative Results ◽  
Sestamibi Scintigraphy ◽  
False Negative Results ◽  
Intraoperative Pth ◽  
Intraoperative Parathyroid Hormone

Background and Aims: Preoperative 99mTc-sestamibi scintigraphy is used by many surgeons to identify the anatomical location of pathological parathyroid glands in patients undergoing surgical treatment for hyperparathyroidism. However, false negative results do occur. It has been suggested that intraoperative parathyroid hormone (PTH) analysis may enhance the possibility of performing successful focused, unilateral neck surgery in these patients. This study aimed to evaluate whether an adequate fall in intraoperative parathyroid hormone values predicts the removal of all hyperfunctioning parathyroid tissue and postoperative normocalcemia. Material and Methods: One hundred consecutive patients undergoing surgery for hyperparathyroidism had preoperative 99mTc-sestamibi scintigraphy and intraoperative parathyroid hormone (PTH) analysis. A fall in intraoperative PTH value by more than 50% of baseline value ended the procedure. This prospective study presents the clinical and biochemical results. Results: The overall sensitivity of the 99mTc-sestamib scintigraphy was 88% and for single adenomas 95%. The scintigraphy failed to detect the correct pathology in all cases with multiglandular disease (7 patients). A fall in intraoperative PTH value by more than 50% of baseline value was achieved in all patients. The combination of intraoperative PTH analysis and 99mTc-sestamibi scintigraphy enabled us to limit the operation to a focused, unilateral operation in 87 of the 100 patients. All patients were normocalcemic postoperatively. Conclusions: A fall in intraoperative PTH value more than 50 % of baseline value seems to predict postoperative normocalcemia and the removal of all hyperfunctioning parathyroid tissue. Bilateral neck exploration is avoided in the majority of patients.

Sign in / Sign up

Export Citation Format

Share Document