Acidic Preconditioning Protects Against Ischemia-Reperfusion Lung Injury Via Inhibiting the Expression of Matrix Metalloproteinase 9

2019 ◽  
Vol 235 ◽  
pp. 569-577 ◽  
Author(s):  
Liang-Chao Qu ◽  
Yan Jiao ◽  
Zhang-Jie Jiang ◽  
Zhi-Ping Song ◽  
Qing-Hua Peng
Keyword(s):  
Lung Injury ◽  
Matrix Metalloproteinase ◽  
Ischemia Reperfusion ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9

scholarly journals Neutrophil Infiltration Increases Matrix Metalloproteinase-9 in the Ischemic Brain after Occlusion/Reperfusion of the Middle Cerebral Artery in Rats

2003 ◽  
Vol 23 (12) ◽  
pp. 1430-1440 ◽  
Author(s):  
Carles Justicia ◽  
Julián Panés ◽  
Sónia Solé ◽  
Álvaro Cervera ◽  
Ramon Deulofeu ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Ischemia Reperfusion ◽  
Neutrophil Infiltration ◽  
Artery Occlusion ◽  
Matrix Metalloproteinase 9 ◽  
Gelatinase Activity ◽  
Ischemic Brain ◽  
Metalloproteinase 9

Matrix metalloproteinase-9 (MMP-9) activity increases in the brain during the first day after focal ischemia and might be involved in the pathogenesis of tissue damage. We previously showed MMP-9 in the extracellular space of brain parenchyma along with neutrophil recruitment after ischemia. In the present study, we tested whether neutrophils were a direct source of enhanced MMP-9 in the ischemic brain. Neutrophil infiltration was prevented either by injecting an antibody against ICAM-1, which abrogates neutrophil adhesion to the endothelial vessel wall, or by inducing neutropenia. One-hour intraluminal middle cerebral artery occlusion with reperfusion was induced, and studies were performed at 24 hours. Circulating neutrophils expressed 95-kDa MMP-9 and dimers, and infiltrated neutrophils stained positive for MMP-9. The expression of MMP-9 (mainly 95-kDa proform and dimers and, to a lesser extent, 88-kDa form) increased in brain after ischemia/reperfusion. Treatments preventing neutrophil infiltration failed to preclude the ischemia-induced increase in 88-kDa MMP-9 form and gelatinase activity in neurons and blood vessels. However, these treatments prevented the major increase in 95-kDa MMP-9 form and dimers. We conclude that neutrophil infiltration highly contributes to enhanced MMP-9 in the ischemic brain by releasing MMP-9 proform, which might participate in the tissular inflammatory reaction.

ACTIVATION OF MATRIX METALLOPROTEINASE 9 DURING LUNG ISCHEMIA-REPERFUSION INJURY.

2000 ◽  
Vol 69 (Supplement) ◽  
pp. S303
Author(s):  
Motoki Yano ◽  
Yosuke Yamakawa ◽  
Yoko Omoto ◽  
Yoshiaki Nakashima ◽  
Yoshitaka Fujii
Keyword(s):  
Matrix Metalloproteinase ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9
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