Postconditioning with sevoflurane ameliorates spatial learning and memory deficit after hemorrhage shock and resuscitation in rats

2016 ◽  
Vol 206 (2) ◽  
pp. 307-315 ◽  
Author(s):  
Xianwen Hu ◽  
Jingxian Wang ◽  
Qiquan Zhang ◽  
Xiaowen Duan ◽  
Zhiwu Chen ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Memory Deficit ◽  
Spatial Learning And Memory ◽  
Learning And Memory Deficit

scholarly journals Prenatal Stress Induced Spatial Memory Deficit in a Sex-Specific Manner in Mice: Possible Involvement of Hippocampal Insulin Resistance

2021 ◽  
Author(s):  
Massomeh Mohammadi ◽  
◽  
Ali Haeri-Rohani ◽  
Parichehr Yaghmaei ◽  
Hedayat Sahraei ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Learning And Memory ◽  
Spatial Learning ◽  
Prenatal Stress ◽  
Insulin Receptors ◽  
Memory Deficit ◽  
Spatial Learning And Memory ◽  
Control Male ◽  
Control Female ◽  
Learning And Memory Deficit

Introduction: In the present study, the effects of prenatal stress on spatial learning and memory deficit and its relationship with hippocampal insulin resistance was examined in male and female offspring. Method: Female NMRI mice were mate with males overnight and the zero day of pregnancy was detected (Gestational day zero-GD0). The pregnant mice were then randomly divided into stress and control groups. The stress group received stress from the GD0 to GD10. On post natal day 30 (PND30) the offspring were divided into for subgroups namely: male-control, female-control, male-stress, and female-stress. Barnes maze (BM) method was used for spatial learning evaluation. Plasma cortisol and insulin levels were measured at the beginning of the experiments. At the end of the experiments, the animals’ brains were removed and their hippocampus was extracted. The hippocampus was homogenized and its insulin and insulin receptor contents were evaluated. Results: The stressed animals needed more time for reaching to target hole. In addition, they spend more distance for finding the target hole, which was more pronounced in the male offspring. Both plasma and hippocampal insulin content were reduced in stressed groups. Moreover, the hippocampal insulin receptors protein was reduced in the stressed animals. There was a positive relationship between plasma and hippocampal content and memory deficit in the stressed groups. Conclusion: These results indicated that prenatal stress can induce spatial learning and memory deficit in offspring which is associated with plasma and hippocampal insulin and receptor content reduction (hippocampal insulin resistance) in these animals.

scholarly journals Intranasal Insulin Prevents Anesthesia-Induced Spatial Learning and Memory Deficit in Mice

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yongli Zhang ◽  
Chun-ling Dai ◽  
Yanxing Chen ◽  
Khalid Iqbal ◽  
Fei Liu ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Memory Deficit ◽  
Spatial Learning And Memory ◽  
Intranasal Insulin ◽  
Learning And Memory Deficit

EPA-enriched ethanolamine plasmalogen and EPA-enriched phosphatidylethanolamine enhance BDNF/TrkB/CREB signaling and inhibit neuronal apoptosis in vitro and in vivo

2020 ◽  
Vol 11 (2) ◽  
pp. 1729-1739 ◽  
Author(s):  
Hongxia Che ◽  
Lingyu Zhang ◽  
Lin Ding ◽  
Wancui Xie ◽  
Xiaoming Jiang ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Neuronal Apoptosis ◽  
Memory Deficit ◽  
Ethanolamine Plasmalogen ◽  
Learning And Memory Deficit

Our previous study showed that EPA-enriched ethanolamine plasmalogen (EPA-pPE) exerted more significant effects than EPA-enriched phosphatidylethanolamine (EPA-PE) in improving learning and memory deficit.

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