Protective Effects of Lycopene on Cerulein-Induced Experimental Acute Pancreatitis in Rats

2012 ◽  
Vol 176 (1) ◽  
pp. 232-238 ◽  
Author(s):  
Erkan Özkan ◽  
Cebrail Akyüz ◽  
Ender Dulundu ◽  
Ümit Topaloğlu ◽  
Ahmet Özer Şehirli ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Protective Effects ◽  
Experimental Acute Pancreatitis

scholarly journals Protective Effects of Hydrogen Gas on Experimental Acute Pancreatitis

PLoS ONE ◽  
2016 ◽  
Vol 11 (4) ◽  
pp. e0154483 ◽  
Author(s):  
Hao-xin Zhou ◽  
Bing Han ◽  
Li-Min Hou ◽  
Ting-Ting An ◽  
Guang Jia ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Hydrogen Gas ◽  
Protective Effects ◽  
Experimental Acute Pancreatitis

The protective effects of taurine on experimental acute pancreatitis in a rat model

2013 ◽  
Vol 32 (5) ◽  
pp. 522-529 ◽  
Author(s):  
C Akay ◽  
H Yaman ◽  
M Oztosun ◽  
E Cakir ◽  
AO Yildirim ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Rat Model ◽  
Protective Effects ◽  
Experimental Acute Pancreatitis

scholarly journals The Protective Effects of Shen-Fu Injection on Experimental Acute Pancreatitis in a Rat Model

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Lei Huang ◽  
Jun Cao
Keyword(s):  
Oxidative Stress ◽  
Acute Pancreatitis ◽  
Nuclear Factor Kappa B ◽  
Treated Group ◽  
The Other ◽  
Nuclear Factor ◽  
Protective Effects ◽  
Experimental Acute Pancreatitis ◽  
Histopathological Studies ◽  
Biochemical Indices

Objectives. In the present study, we investigated the protective effects of Shen-Fu injection (SFI) on a caerulein-induced rat pancreatitis (AP) model.Methods. SFI was given to rats in the SFI treated group through intraperitoneal injection. Blood and pancreas samples were collected for serological and histopathological studies.Results. Our results showed that AP caused significant decrease in tissue glutathione (GSH) and serum IL-4 and IL-10, while pancreatic malondialdehyde (MDA) and myeloperoxidase (MPO) were increased. Furthermore, TNF-α, IL-1β, amylase, and lipase levels were also significantly increased. On the other hand, SFI treatment reserved all these biochemical indices as well as histopathologic alterations that were induced by caerulein.Conclusion. Our findings suggest that the SFI protects against caerulein-induced AP in rats via modulation of cytokines, oxidative stress, and Nuclear Factor-kappa B (NF-κB) activity.

scholarly journals Necroptosis protects against exacerbation of acute pancreatitis

2021 ◽  
Vol 12 (6) ◽  
Author(s):  
Michittra Boonchan ◽  
Hideki Arimochi ◽  
Kunihiro Otsuka ◽  
Tomoko Kobayashi ◽  
Hisanori Uehara ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Necrotizing Pancreatitis ◽  
Neutrophil Infiltration ◽  
Dependent Manner ◽  
Protective Effects ◽  
Interacting Protein ◽  
Inflammatory Conditions ◽  
Edematous Pancreatitis ◽  
Genetic Deletion ◽  
Dose Dependent

AbstractThe sensing of various extrinsic stimuli triggers the receptor-interacting protein kinase-3 (RIPK3)-mediated signaling pathway, which leads to mixed-lineage kinase-like (MLKL) phosphorylation followed by necroptosis. Although necroptosis is a form of cell death and is involved in inflammatory conditions, the roles of necroptosis in acute pancreatitis (AP) remain unclear. In the current study, we administered caerulein to Ripk3- or Mlkl-deficient mice (Ripk3−/− or Mlkl−/− mice, respectively) and assessed the roles of necroptosis in AP. We found that Ripk3−/− mice had significantly more severe pancreatic edema and inflammation associated with macrophage and neutrophil infiltration than control mice. Consistently, Mlkl−/− mice were more susceptible to caerulein-induced AP, which occurred in a time- and dose-dependent manner, than control mice. Mlkl−/− mice exhibit weight loss, edematous pancreatitis, necrotizing pancreatitis, and acinar cell dedifferentiation in response to tissue damage. Genetic deletion of Mlkl resulted in downregulation of the antiapoptotic genes Bclxl and Cflar in association with increases in the numbers of apoptotic cells, as detected by TUNEL assay. These findings suggest that RIPK3 and MLKL-mediated necroptosis exerts protective effects in AP and caution against the use of necroptosis inhibitors for AP treatment.

scholarly journals Effect of inhibition of prostaglandin E2 production on pancreatic infection in experimental acute pancreatitis

HPB ◽  
2007 ◽  
Vol 9 (5) ◽  
pp. 392-397 ◽  
Author(s):  
Andre S. Matheus ◽  
Ana Maria M. Coelho ◽  
Sandra Sampietre ◽  
Rosely Patzina ◽  
Jose Jukemura ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Prostaglandin E2 ◽  
Experimental Acute Pancreatitis ◽  
Pancreatic Infection

scholarly journals Influence of pancreatic enzyme content on pulmonary lesions of experimental acute pancreatitis

HPB ◽  
2000 ◽  
Vol 2 (4) ◽  
pp. 389-393 ◽  
Author(s):  
J.E.M. Cunha ◽  
M.Z. Salem ◽  
A.M. Coelho ◽  
M.S. Kubrusly ◽  
S.N. Sampietri ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Pancreatic Enzyme ◽  
Experimental Acute Pancreatitis ◽  
Pulmonary Lesions ◽  
Enzyme Content

Recombinant Reg3α protein protects against experimental acute pancreatitis in mice

2016 ◽  
Vol 422 ◽  
pp. 150-159 ◽  
Author(s):  
Lu-Ting Yu ◽  
Meng-Qi Yang ◽  
Jun-Li Liu ◽  
Martin O. Alfred ◽  
Xiang Li ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Experimental Acute Pancreatitis

scholarly journals The role of the liver in the development of respiratory failure in experimental acute pancreatitis (AP)

HPB ◽  
2016 ◽  
Vol 18 ◽  
pp. e324-e325
Author(s):  
P. Miguel ◽  
J. Camelione ◽  
L. Cardozo Bidart ◽  
R. Trapani ◽  
P. Curvale ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Respiratory Failure ◽  
Experimental Acute Pancreatitis
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