COX-2: a target for prevention and treatment of esophageal cancer

2004 ◽  
Vol 117 (1) ◽  
pp. 114-120 ◽  
Author(s):  
Nasser Altorki
Keyword(s):  
Esophageal Cancer ◽  
Prevention And Treatment ◽  
Cox 2

COX-2 Inhibition in Esophagitis, Barretts Esophagus and Esophageal Cancer

2003 ◽  
Vol 9 (27) ◽  
pp. 2267-2280 ◽  
Author(s):  
E. Piazuelo ◽  
P. Jimenez ◽  
A. Lanas
Keyword(s):  
Esophageal Cancer ◽  
Cox 2 ◽  
Barretts Esophagus

scholarly journals Deoxycholate induces COX-2 expression via Erk1/2-, p38-MAPK and AP-1-dependent mechanisms in esophageal cancer cells

BMC Cancer ◽  
2009 ◽  
Vol 9 (1) ◽  
Author(s):  
Eileen Looby ◽  
Mohamed MM Abdel-Latif ◽  
Veronica Athié-Morales ◽  
Shane Duggan ◽  
Aideen Long ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Cancer Cells ◽  
P38 Mapk ◽  
Cox 2 ◽  
Esophageal Cancer Cells

Resveratrol and Colorectal Cancer: A Molecular Approach to Clinical Researches

2021 ◽  
Vol 21 ◽  
Author(s):  
Eisa Kaveh Vernousfaderani ◽  
Negin Akhtari ◽  
Sara Rezaei ◽  
Yasaman Rezaee ◽  
Saba Shiranirad ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Pentose Phosphate Pathway ◽  
Clinical Studies ◽  
Pentose Phosphate ◽  
Pharmacological Effects ◽  
Molecular Approach ◽  
Prevention And Treatment ◽  
Cox 2

: Phytochemicals are the most valuable and comprehensive structures, which may have a broad range of protective benefits, from reducing inflammation and speeding healing to preventing infection and fighting cancer. Resveratrol (RSV) is a natural phenolic compound from the oligomeric stilbenoid group, which is usually found in human daily diets such as grape, peanut, berries and grains. It exhibits anti-inflammatory, neuroprotection, antioxidant and cancer prevention and treatment effects. RSV is thought to have an impressive outcome in colorectal cancer (CRC) treatment through the vital molecules and cancer signaling pathways, including SIRT1, P53, P21, AMPK, ROS, BMP7, COX-2, NO, Caspases, Wnt, TNFs, NF-κB, EMT, and pentose phosphate pathway. Therefore, this paper reviews the current researches on resveratrol pharmacological effects and pharmacokinetic and drug delivery system, as well as clinical studies in CRC.

scholarly journals Prevention and Treatment of Esophageal Cancer in China: Achievements and Challenges-Prevention is the Key

2017 ◽  
Vol 4 (2) ◽  
Author(s):  
Huimin Zhao ◽  
Weiwei Zhang ◽  
Donghui Jia ◽  
Aiming Li ◽  
Yangming F Wang
Keyword(s):  
Esophageal Cancer ◽  
Prevention And Treatment

IL1R2 Polymorphisms are Associated with Increased Risk of Esophageal Cancer

2020 ◽  
Vol 20 (5) ◽  
pp. 379-387
Author(s):  
Jianfeng Liu ◽  
Yonghui Yang ◽  
Haiyue Li ◽  
Yuanwei Liu ◽  
Yao Sun ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Odds Ratio ◽  
Chinese Population ◽  
Additive Models ◽  
Nucleotide Polymorphisms ◽  
Chinese Han ◽  
Single Nucleotide ◽  
Han Population ◽  
Increased Risk ◽  
Prevention And Treatment

Background: Esophageal cancer (EC) is the sixth leading cause of cancer death worldwide, and the overall incidence is increasing. Objective: The aim of this study was to evaluate the association between single nucleotide polymorphisms in IL1R2 and EC risk in the Chinese population. Methods: Genotyping of six SNPs of IL1R2 was performed with the Agena MassARRAY platform from 384 EC and 499 controls. The association between polymorphisms and EC risk was assessed by performing genetics models and haplotype analyses. Results: Overall analysis results showed that the allele C of rs11674595 (odds ratio [OR] = 1.42, 95% confidence interval [CI]: 1.14-1.77, p = 0.002) and allele G of rs2072472 (allele: OR = 1.35, 95% CI: 1.08-1.69, p = 0.008) were associated with an increased EC risk. The rs11674595 and rs2072472 were found to be correlated with EC risk under the codominant, dominant, and additive models. Stratification analysis found that rs11674595 and rs2072472 were associated with increased EC risk in male and in age > 55 years old subgroup. In addition, Crs11674595Grs4851527 haplotype was significantly associated with 1.44-fold increased risk of EC (95% CI: 1.12-1.84, p = 0.004). Conclusions : Our results reveal the significant association between SNPs (rs11674595 and rs2072472) in the IL1R2 and EC risk in the Chinese Han population. The findings may provide meaningful reference for the prevention and treatment of EC.

Cyclooxygenase-2 (COX-2) expression after neoadjuvant chemoradiotherapy and response to platinum/taxanes containing adjuvant chemotherapy in esophageal cancer

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 15032-15032
Author(s):  
Y. Fujiwara ◽  
R. Yoshikawa ◽  
K. Koishi ◽  
T. Matsumoto ◽  
S. Kojima ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Adjuvant Chemotherapy ◽  
Univariate Analysis ◽  
Neoadjuvant Chemoradiotherapy ◽  
Disease Free Survival ◽  
Early Recurrence ◽  
Cyclooxygenase 2 ◽  
The Status ◽  
Cox 2 ◽  
Prostaglandin H

15032 Background: Cyclooxygenase-2 (COX-2) is an inducible enzyme linked to the conversion of arachidonic acid to prostaglandin H2. Recent reports have indicated that tumor with high COX-2 expression are refractory to chemotherapy and associated with poor outcome. In this study, we investigated the relationship of COX-2 expressive tumor with response to platinum/taxanes chemotherapy and its clinical significance in esophageal cancer patients undergoing chemoradiotherapy (CRT). Methods: COX-2 expressions were evaluated in 53 patients with histologically confirmed esophageal squamous cell carcinoma (ESCC) undergoing preoperative CRT, by immunohistochemical staining. Preoperative CRT was consisted of 5-FU plus cisplatin chemotherapy and total 40Gy irradiation. Platinum/taxanes treatment was chosen for the first-line adjuvant chemotherapy. Results: 17 patients showed a pathological CR in the resected specimens. COX-2 expression was absent from 14 tumors (38.9%), and positive in other 22 tumors (61.1%). Recurrences were found in 15 patients in COX-2 (+) group, and in 5 patients in COX-2 (-) group (p=0.0874). There were significant associations between OS and effect of CRT, Lymph nodes metastasis, and distant metastasis (p=0.00004, p=0.0095, and p=0.0277, respectively). COX-2 expression showed a significant prognostic value for DFS (p=0.0401), but not for the OS with univariate analysis. Intriguingly, platinum/taxanes chemotherapy succeeded in improving OS in the recurrence group (p=0.0188). Conclusions: Our data suggests that positive COX-2 expression after CRT correlates with early recurrence of ESCC patient after CRT and possible prognostic factor in disease-free survival. Adjuvant chemotherapy after surgery is much more influential for prognosis in the ESCC patients than the status of COX-2 expression after CRT. COX-2 status might provide a preferable choice for platinum/taxanes in postoperative adjuvant setting. No significant financial relationships to disclose.

Etiological involvement of weak acid reflux in the development of esophageal carcinoma.

2020 ◽  
Vol 38 (4_suppl) ◽  
pp. 435-435
Author(s):  
Toru Kono ◽  
Daichi Sadatomi ◽  
Naoki Fujitsuka ◽  
Tomoharu Miyashita ◽  
Atsushi Kaneko ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Bile Acid ◽  
Gastric Acid ◽  
Acid Reflux ◽  
Weak Acid ◽  
Pge2 Production ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cancer Pathogenesis ◽  
Increased Risk ◽  
Cox 2

435 Background: Patients with gastroesophageal reflux disease (GERD) with mixed gastric acid–bile acid reflux are at a high risk of developing reflux-induced esophageal cancer. Increased local production of prostaglandin E2 (PGE2) is etiologically associated with reflux-induced esophageal cancer pathogenesis; however, the underlying mechanism remains unclear. Our aim was to investigate the relationship between PGE2 production in esophageal cells and reflux fluids, particularly gastric acid. The effect of the Kampo medicine Hangeshashinto (HST), which reduced the incidence of reflux-induced esophageal cancer in rats (Surgery 2018), on PGE2 production was also examined. Methods: Esophageal squamous cell carcinoma were treated for 2 h with acidic culture condition (pH 3.5 – 6.5) and chenodeoxycholic acid (CDCA; 200, 400 μmol/L), followed by measurement of PGE2 production in the culture medium for the additional 6 h by enzyme-linked immunosorbent assay. Results: CDCA induced PGE2 production and significantly increased cyclooxygenase-2 (cox-2) expression. However, in weak acidic conditions (pH 4–5), a pH-specific and significant increase in PGE2 production with no increase in cox-2 expression was observed. cPLA2 inhibitor decreased the effect of weak acid stimulation, indicating that the mechanism underlying PGE2 production differs between weak acid and CDCA. In addition, HST significantly inhibited both weak acid- and CDCA-induced PGE2 production. Conclusions: The synergistic effect of bile acid-induced cox-2 expression and weak acid-induced arachidonic acid production via cPLA2 can cause excessive PGE2 production. Therefore, mixed reflux showing pH 4–5 could contribute to the high incidence of esophageal cancer, which might be prevented by HST treatment. Weak acid reflux around pH 4–5 has been observed in PPI-treated patients, who could exhibit excessive PGE2 production as well as increased risk of reflux-induced esophageal cancer.

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