scholarly journals Formulation and in vitro evaluation of theophylline matrix tablets prepared by direct compression: Effect of polymer blends

2012 ◽  
Vol 20 (3) ◽  
pp. 229-238 ◽  
Author(s):  
Ibrahim El-Bagory ◽  
Nahla Barakat ◽  
Mohamed A. Ibrahim ◽  
Fouza El-Enazi
Keyword(s):  
Polymer Blends ◽  
Matrix Tablets ◽  
Direct Compression ◽  
In Vitro Evaluation ◽  
Compression Effect

scholarly journals FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF LORNOXICAM BY DIRECT COMPRESSION METHOD

2021 ◽  
Vol 10 (5) ◽  
pp. 131-136
Author(s):  
Asim pasha ◽  
C N Somashekhar
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Matrix Tablets ◽  
In Vitro Dissolution ◽  
Prolonged Release ◽  
Matrix Tablet ◽  
Direct Compression ◽  
Dissolution Profile ◽  
Drug Content

The aim of the present work was to develop sustained release Lornoxicam matrix tablets with polymers like HPMC K15M, Ethyl cellulose, and Crospovidone as carriers in varying quantities. Direct compression was used to make matrix tablets. Various assessment parameters, such as hardness, friability, thickness, percent drug content, weight variation, and so on, were applied to the prepared formulations. In vitro dissolution studies were carried out for 24 hrs. The tablets were subjected to in-vitro drug release in (pH 1.2) for first 2 hrs. Then followed by (pH 6.8) phosphate buffer for next 22 hrs. And the results showed that among the six formulations FL3 showed good dissolution profile to control the drug release respectively. The drug and polymer compatibility were tested using FT-IR spectroscopy, which revealed that the drug was compatible with all polymers. It is also required to design an appropriate prolonged release formulation for Lornoxicam in order to maintain the drug's release. Hence by using the compatible polymers sustained release tablets were formulated and subjected for various types of evaluation parameters like friability, hardness, drug content and dissolution behaviour. Finally, the findings reveal that the prepared sustained release matrix tablets of lornoxicam have improved efficacy and patient compliance.

Formulation and In vitro Evaluation of Matrix Tablets containing Pioglitazone

2019 ◽  
Vol 12 (6) ◽  
pp. 3017
Author(s):  
C C Patil ◽  
Shedyal Bhairappa ◽  
K Vijapure Vitthal
Keyword(s):  
Matrix Tablets ◽  
In Vitro Evaluation
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