Effects of Long-Term, High-Altitude Hypoxia on Tension and Intracellular Calcium Responses in Coronary Arteries of Fetal and Adult Sheep

2006 ◽  
Vol 13 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Satoshi Kono ◽  
Virginia M. Stiffel ◽  
Raymond D. Gilbert
Keyword(s):  
High Altitude ◽  
Intracellular Calcium ◽  
Coronary Arteries ◽  
Altitude Hypoxia ◽  
Adult Sheep ◽  
High Altitude Hypoxia

scholarly journals Long-Term High-Altitude Hypoxia and Alpha Adrenoceptor-Dependent Pulmonary Arterial Contractions in Fetal and Adult Sheep

2019 ◽  
Vol 10 ◽  
Author(s):  
Dafne Moretta ◽  
Demosthenes G. Papamatheakis ◽  
Daniel P. Morris ◽  
Paresh C. Giri ◽  
Quintin Blood ◽  
...  
Keyword(s):  
High Altitude ◽  
Altitude Hypoxia ◽  
Adult Sheep ◽  
Alpha Adrenoceptor ◽  
High Altitude Hypoxia ◽  
Pulmonary Arterial

Ca2+ Sensitivity of Fetal Coronary Arteries Exposed to Long-Term, High-Altitude Hypoxia

2000 ◽  
Vol 7 (3) ◽  
pp. 161-166 ◽  
Author(s):  
Felizabel C. Garcia ◽  
Virginia M. Stiffel ◽  
William J. Pearce ◽  
Lubo Zhang ◽  
Raymond D. Gilbert
Keyword(s):  
High Altitude ◽  
Coronary Arteries ◽  
Altitude Hypoxia ◽  
High Altitude Hypoxia

Heme oxygenase activity in fetal and adult sheep is not altered by acclimatization to high altitude hypoxia

2006 ◽  
Vol 84 (8-9) ◽  
pp. 893-901 ◽  
Author(s):  
Robert T. Kinobe ◽  
Jason Z. Vlahakis ◽  
Jonathan M. Soong ◽  
Walter A. Szarek ◽  
James F. Brien ◽  
...  
Keyword(s):  
High Altitude ◽  
Heme Oxygenase ◽  
Stress Proteins ◽  
Degradation Products ◽  
Fetal Tissue ◽  
Altitude Hypoxia ◽  
Adult Sheep ◽  
High Altitude Hypoxia

Hypoxic stress has been reported to induce the expression of stress proteins such as heme oxygenase (HO), which catalyze the breakdown of heme to generate biliverdin, ferrous iron, and carbon monoxide. These degradation products play a role in the regulation of a variety of processes such as vascular tone, inflammation, and central nervous system function. In mammals, there are 2 catalytically functional HO isozymes, HO-1 (inducible) and HO-2 (constitutive). HO-1 expression is regulated by an array of nonphysiological and physiological stimuli including acute hypoxemia. As relatively little is known of the HO response to prolonged hypoxia in whole animals other than small laboratory rodents, the aim of this work was to examine the effect of long-term hypoxia on total HO activity in fetal and adult ovine tissue. Sheep were maintained at high altitude (3820 m), after which the following tissues were harvested from near-term fetal and non-pregnant ewes for in vitro measurement of HO activity: left ventricle, renal papilla, lung apex, pulmonary artery, carotid artery, mesenteric artery, placental cotyledon, spleen, and brain frontal cortex. There were no significant differences between HO activities in tissues from hypoxic fetal and adult sheep compared with their normoxic controls. Fetal heart HO activities were higher than those of adult tissue (p < 0.05), whereas adult spleen HO activity was significantly higher than that of fetal tissue (p < 0.05). In conclusion, these data indicate that long-term exposure to high altitude hypoxia does not have a persistent effect on HO activity in ovine tissues. Also, except for the spleen where there is a high expression of HO-1 under normal conditions, tissue HO activity is correlated with the expression of HO-2, the constitutive isozyme.

scholarly journals Preservation of Serotonin-Mediated Contractility in Adult Sheep Pulmonary Arteries Following Long-Term High-Altitude Hypoxia

2011 ◽  
Vol 12 (3) ◽  
pp. 253-264 ◽  
Author(s):  
Demosthenes G. Papamatheakis ◽  
Srilakshmi Vemulakonda ◽  
Quintin Blood ◽  
Ravi Goyal ◽  
Monica Rubalcava ◽  
...  
Keyword(s):  
High Altitude ◽  
Pulmonary Arteries ◽  
Altitude Hypoxia ◽  
Adult Sheep ◽  
High Altitude Hypoxia
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