Predictive Value of Maternal Serum and Vaginal Interleukin-6 Levels in Preterm Labor

2005 ◽  
Vol 12 (4) ◽  
pp. e1-e6 ◽  
Author(s):  
S SOZMEN ◽  
T MUNGAN ◽  
S MICOZKADIOGLU ◽  
O TAPISIZ
Keyword(s):  
Interleukin 6 ◽  
Predictive Value ◽  
Preterm Labor ◽  
Maternal Serum

Maternal serum interleukin-6, interleukin-8, tumor necrosis factor-α and interferon-γ in preterm labor

2003 ◽  
Vol 82 (6) ◽  
pp. 543-549
Author(s):  
Ahmed M. Bahar ◽  
Hashim W. Ghalib ◽  
Riyad A. Moosa ◽  
Zaki M. S. Zaki ◽  
Chet Thomas ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Preterm Labor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interferon Γ ◽  
Maternal Serum ◽  
Interleukin 8 ◽  
Factor Α ◽  
Necrosis Factor

Maternal serum interleukin-6, interleukin-8, tumor necrosis factor-α and interferon-γ in preterm labor

2003 ◽  
Vol 82 (6) ◽  
pp. 543-549 ◽  
Author(s):  
Ahmed M. Bahar ◽  
Hashim W. Ghalib ◽  
Riyad A. Moosa ◽  
Zaki M. S. Zaki ◽  
Chet Thomas ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Interleukin 6 ◽  
Preterm Labor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interferon Γ ◽  
Maternal Serum ◽  
Interleukin 8 ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Serum urocortin in preterm labor is it an effective biomarker?

2019 ◽  
Vol 8 (6) ◽  
pp. 2522
Author(s):  
Nancy Mohamed Ali Rund
Keyword(s):  
Predictive Value ◽  
Preterm Labor ◽  
Characteristic Curve ◽  
Serum Levels ◽  
Maternal Serum ◽  
Future Research ◽  
Research Groups ◽  
Racial And Ethnic Differences ◽  
Term Delivery ◽  
The Impact

Background: Preterm labor classically defined as delivery before completed 37 gestational weeks. Urocortin a biomarker that have raised recent research interest is a 40-amino acid neuropeptide related to the corticotrophin-releasing factor molecular family. Interestingly urocortin is produced by gestational tissue such as amnion and chorion predictability of preterm labor by biomarker assay could enhance management levels particularly in cases of preterm labor that are considered a frequent clinical scenario in obstetric practice. Aim of the study was to assess and evaluate the serum levels of urocortin predictability capacity in cases that develop preterm labor.Methods: The current research clinical trial was conducted in a prospective way there was two research groups 60 study subjects had threatened preterm labor and 60 normal research study subjects that delivered at term. Comparative analysis was performed for urocortin assay conducted in both research groups in correlation to gathered clinical data obtained from both research groups.Results: Receiver operating characteristic curve (ROC) between preterm and term delivery research groups as regards plasma urocortin level (pg/ml) as a predictor of pre term delivery showing that a cut-off point level >101.3 pg/ml in which statistical sensitivity=88.33%, statistical specificity=75%, positive predictive value=77.9, negative predictive value=86.5.Conclusions: This research finding reveal that maternal serum urocortin is an effective biomarker in predictability of preterm labor; however future research studies should be multicentric in fashion putting in consideration the racial and ethnic differences besides the impact of BMI on maternal serum urocortin indices.

Accuracy of a combined insulin-like growth factor-binding protein-1/interleukin-6 test (Premaquick) in predicting delivery in women with threatened preterm labor

2017 ◽  
Vol 45 (8) ◽  
Author(s):  
George Uchenna Eleje ◽  
Euzebus Chinonye Ezugwu ◽  
Ahizechukwu Chigoziem Eke ◽  
Lydia Ijeoma Eleje ◽  
Joseph Ifeanyichukwu Ikechebelu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Interleukin 6 ◽  
Predictive Value ◽  
Preterm Labor ◽  
Predictive Accuracy ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Threatened Preterm Labor ◽  
Singleton Pregnancies

AbstractPurpose:To determine values of combinations of interleukin-6 (IL-6)/cervical native insulin-like growth factor-binding protein-1 (IGFBP-1)/total IGFBP-1 (Premaquick©) in predicting spontaneous deliveries and spontaneous exclusive preterm deliveries in women with threatened preterm labor.Methods:Women with singleton pregnancies between gestation age (GA) of 24 weeks and 36 weeks and 6 days with preterm labor were recruited during a prospective multicenter study. Premaquick© was positive when at least two of three biomarkers were positive. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy were estimated for both prediction of spontaneous deliveries and spontaneous exclusive preterm deliveries.Results:Ninety-seven (99.0%) out of 98 women enrolled were analyzed. Based on delivery status 7/14 days post-enrollment of general study population, Premaquick© had a sensitivity of 87.1/85.7%, a specificity of 92.4/96.8%, a PPV of 84.4/93.8% and a NPV of 93.9/92.3% for prediction of spontaneous delivery. Predictive accuracy of Premaquick© test in relation to days of enrollment were: 90.7% (≤7 days) and 92.8% (≤14 days). For women enrolled at GA <35 weeks, Premaquick© had a sensitivity of 100.0/87.5%, a specificity of 94.1/96.9%, a PPV of 70.5/87.5%, a NPV of 100.0/96.9% and an accuracy of 95.0/95.0% for prediction of preterm delivery within 7/14 days of enrollment, respectively. PPV was most significantly different in both groups when outcomes were compared between 2 days and 14 days post-enrollment (P<0.001).Conclusion:This novel triple biomarker model of native and total IGFBP-1 and IL-6 appears to be an accurate test in predicting spontaneous deliveries and spontaneous exclusive preterm deliveries in threatened preterm labor in singleton pregnancies.

Predictive value of combined amniotic fluid proteomic biomarkers and interleukin-6 in preterm labor with intact membranes

2009 ◽  
Vol 200 (5) ◽  
pp. 499.e1-499.e6 ◽  
Author(s):  
Teresa Cobo ◽  
Montse Palacio ◽  
Aleix Navarro-Sastre ◽  
Antonia Ribes ◽  
Jordi Bosch ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Interleukin 6 ◽  
Predictive Value ◽  
Preterm Labor

Predictive value of serum interleukin-6 and -8 levels in preterm labor or rupture of the membranes

2000 ◽  
Vol 79 (8) ◽  
pp. 667-672 ◽  
Author(s):  
GUNTER MINCKWITZ ◽  
EVA-MARIA GRISCHKE ◽  
STEFANIE SCHWAB ◽  
SUSANNE HETTINGER ◽  
SIBYLLE LOIBL ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Predictive Value ◽  
Preterm Labor

Maternal Serum Interleukin-6 During Pregnancy and During Term and Preterm Labor

1997 ◽  
Vol 90 (3) ◽  
pp. 465-469 ◽  
Author(s):  
P GREIG ◽  
A MURTHA ◽  
C JIMMERSON ◽  
W HERBERT ◽  
B ROITMANJOHNSON ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Preterm Labor ◽  
Maternal Serum
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