Vascular Endothelial Growth Factor Activation of Intramembranous Absorption: A Critical Pathway for Amniotic Fluid Volume Regulation

2004 ◽  
Vol 11 (2) ◽  
pp. 63-74 ◽  
Author(s):  
Cecilia Y. Cheung
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Amniotic Fluid ◽  
Volume Regulation ◽  
Fluid Volume ◽  
Vascular Endothelial ◽  
Critical Pathway ◽  
Amniotic Fluid Volume ◽  
Fluid Volume Regulation ◽  
Endothelial Growth Factor

scholarly journals Prostaglandin E2 regulation of amnion cell vascular endothelial growth factor expression: relationship with intramembranous absorption rate in fetal sheep

2014 ◽  
Vol 307 (3) ◽  
pp. R354-R360 ◽  
Author(s):  
Cecilia Y. Cheung ◽  
Michael K. Beardall ◽  
Debra F. Anderson ◽  
Robert A. Brace
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Amniotic Fluid ◽  
Absorption Rate ◽  
Mrna Levels ◽  
Vascular Endothelial ◽  
Fetal Sheep ◽  
Fluid Infusion ◽  
Caveolin 1 ◽  
Endothelial Growth Factor

We hypothesized that prostaglandin E2 (PGE2) stimulates amniotic fluid transport across the amnion by upregulating vascular endothelial growth factor (VEGF) expression in amnion cells and that amniotic PGE2 concentration correlates positively with intramembranous (IM) absorption rate in fetal sheep. The effects of PGE2 at a range of concentrations on VEGF164 and caveolin-1 gene expressions were analyzed in cultured ovine amnion cells. IM absorption rate, amniotic fluid (AF) volume, and PGE2 concentration in AF were determined in late-gestation fetal sheep during control conditions, isovolumic fetal urine replacement (low IM absorption rate), or intra-amniotic fluid infusion (high IM absorption rate). In ovine amnion cells, PGE2 induced dose- and time-dependent increases in VEGF164 mRNA levels and reduced caveolin-1 mRNA and protein levels. VEGF receptor blockade abolished the caveolin-1 response, while minimally affecting the VEGF response to PGE2. In sheep fetuses, urine replacement reduced amniotic PGE2 concentration by 58%, decreased IM absorption rate by half, and doubled AF volume ( P < 0.01). Intra-amniotic fluid infusion increased IM absorption rate and AF volume ( P < 0.01), while amniotic PGE2 concentration was unchanged. Neither IM absorption rate nor AF volume correlated with amniotic PGE2 concentration under each experimental condition. Although PGE2 at micromolar concentrations induced dose-dependent responses in VEGF and caveolin-1 gene expression in cultured amnion cells consistent with a role of PGE2 in activating VEGF to mediate AF transport across the amnion, amniotic PGE2 at physiological nanomolar concentrations does not appear to regulate IM absorption rate or AF volume.

Amniotic fluid volume regulation

2016 ◽  
Vol 2_2016 ◽  
pp. 44-48 ◽  
Author(s):  
Korenovsky Yu.V. Korenovsky ◽  
Kalitnikova I.A. Kalitnikova ◽  
Buryakova S.I. Buryakova ◽  
Popovtseva A.V. Popovtseva A ◽  
Suzopov E.V. Suzopov ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Volume Regulation ◽  
Fluid Volume ◽  
Amniotic Fluid Volume ◽  
Fluid Volume Regulation

Monoclonal anti-vascular endothelial growth factor antibody reduces fluid volume in an experimental model of inflammatory pleural effusion

Respirology ◽  
2009 ◽  
Vol 14 (8) ◽  
pp. 1188-1193 ◽  
Author(s):  
Sabrina C.C. RIBEIRO ◽  
Francisco S. VARGAS ◽  
Leila ANTONANGELO ◽  
Evaldo MARCHI ◽  
Eduardo H. GENOFRE ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Pleural Effusion ◽  
Experimental Model ◽  
Fluid Volume ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

scholarly journals Vascular Endothelial Growth Factor Up-regulation in Human Amniotic Fluid Stem Cell Enhances Nephroprotection After Ischemia-Reperfusion Injury in the Rat

2017 ◽  
Vol 45 (1) ◽  
pp. e86-e96 ◽  
Author(s):  
Marina Gabriela Monteiro Carvalho Mori da Cunha ◽  
Silvia Zia ◽  
Diego Vilibaldo Beckmann ◽  
Marianne Sylvia Carlon ◽  
Fanny Oliveira Arcolino ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Stem Cell ◽  
Growth Factor ◽  
Amniotic Fluid ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Vascular Endothelial ◽  
Human Amniotic Fluid ◽  
Amniotic Fluid Stem Cell ◽  
Endothelial Growth Factor

scholarly journals Excess soluble vascular endothelial growth factor receptor-1 in amniotic fluid impairs lung growth in rats: linking preeclampsia with bronchopulmonary dysplasia

2012 ◽  
Vol 302 (1) ◽  
pp. L36-L46 ◽  
Author(s):  
Jen-Ruey Tang ◽  
S. Ananth Karumanchi ◽  
Gregory Seedorf ◽  
Neil Markham ◽  
Steven H. Abman
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Amniotic Fluid ◽  
Bronchopulmonary Dysplasia ◽  
Growth Factor Receptor ◽  
In Utero ◽  
Vascular Endothelial ◽  
Lung Growth ◽  
Vegf Signaling ◽  
Endothelial Growth Factor

Epidemiological studies have shown that maternal preeclampsia (PE) increases the risk of bronchopulmonary dysplasia (BPD), but the underlying mechanism is unknown. Soluble vascular endothelial growth factor receptor-1 (soluble VEGFR1, known as soluble fms-like tyrosine kinase 1, or sFlt-1), an endogenous antagonist of vascular endothelial growth factor (VEGF), is markedly elevated in amniotic fluid and maternal blood in PE. Therefore, we hypothesized that antenatal exposure to excess sFlt-1 disrupts lung development through impaired VEGF signaling in utero, providing a mechanistic link between PE and BPD. To determine whether increased sFlt-1 in amniotic fluid is sufficient to cause sustained abnormalities of lung structure during infancy, sFlt-1 or saline was injected into amniotic sacs of pregnant Sprague-Dawley rats at 20 days of gestation (term, 22 days). After birth, pups were observed through 14 days of age for study. We found that intra-amniotic sFlt-1 treatment decreased alveolar number, reduced pulmonary vessel density, and caused right and left ventricular hypertrophy in 14-day-old rats. In addition, intra-amniotic sFlt-1 treatment suppressed activation of lung VEGF receptor-2 and increased apoptosis in endothelial and mesenchymal cells in the newborn lung. We conclude that exposure to excess sFlt-1 in amniotic fluid during late gestation causes sustained reductions in alveolarization and pulmonary vascular growth during infancy, accompanied by biventricular hypertrophy suggesting pulmonary and systemic hypertension. We speculate that impaired VEGF signaling in utero due to exposure of high amniotic fluid levels of sFlt-1 in PE disrupts lung growth and contributes to the increased risk of BPD in infants born to mothers with PE.

Concentrations of vascular endothelial growth factor C and D in amniotic fluid and maternal plasma

2009 ◽  
Vol 88 (6) ◽  
pp. 629-634 ◽  
Author(s):  
Katja-Anneli Wathén ◽  
Ulf-Håkan Stenman ◽  
Elina Leinonen ◽  
Sture Andersson ◽  
Piia Vuorela
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Amniotic Fluid ◽  
Maternal Plasma ◽  
Vascular Endothelial ◽  
Factor C ◽  
Endothelial Growth Factor
Sign in / Sign up

Export Citation Format

Share Document