Long-term effects of the rhapontic rhubarb extract ERr 731® on estrogen-regulated targets in the uterus and on the bone in ovariectomized rats

2012 ◽  
Vol 128 (1-2) ◽  
pp. 62-68 ◽  
Author(s):  
Annekathrin Martina Keiler ◽  
Anja Papke ◽  
Georg Kretzschmar ◽  
Oliver Zierau ◽  
Günter Vollmer
Keyword(s):  
Ovariectomized Rats ◽  
Long Term Effects

scholarly journals Long-term effects of alendronate on fracture healing and bone remodeling of femoral shaft in ovariectomized rats

2013 ◽  
Vol 34 (3) ◽  
pp. 387-392 ◽  
Author(s):  
Ling-jie Fu ◽  
Ting-ting Tang ◽  
Yong-qiang Hao ◽  
Ke-rong Dai
Keyword(s):  
Fracture Healing ◽  
Bone Remodeling ◽  
Femoral Shaft ◽  
Ovariectomized Rats ◽  
Long Term Effects

Short-term and long-term effects of osteoporosis on incisor teeth and femoral bones evaluated by Raman spectroscopy and energy dispersive X-ray analysis in ovariectomized rats

2018 ◽  
Vol 37 (1) ◽  
pp. 18-27 ◽  
Author(s):  
Fernanda Rossi Paolillo ◽  
Renan Arnon Romano ◽  
Luciana de Matos ◽  
Airton Abrahão Martin ◽  
Francisco Eduardo Gontijo Guimarães ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Energy Dispersive ◽  
Ovariectomized Rats ◽  
Long Term Effects ◽  
Short Term ◽  
X Ray

Comparison of the Long-Term Effects of Estrogen and Clomiphene Citrate on Pituitary and Uterine Function in Ovariectomized Rats

1991 ◽  
Vol 31 (1) ◽  
pp. 23-29 ◽  
Author(s):  
Janine Brown ◽  
Sharon J. Byrd ◽  
Annette Mitchell ◽  
Myra F. Nelson ◽  
Ronald L. Young ◽  
...  
Keyword(s):  
Clomiphene Citrate ◽  
Ovariectomized Rats ◽  
Long Term Effects ◽  
Uterine Function

Ovarian Dysfunction in Fetally Irradiated Beagles

1977 ◽  
Vol 35 ◽  
pp. 658-659
Author(s):  
T. M. Seed ◽  
M. H. Sanderson ◽  
D. L. Gutzeit ◽  
T. E. Fritz ◽  
D. V. Tolle ◽  
...  
Keyword(s):  
Gamma Rays ◽  
Low Dose ◽  
Long Term Effects ◽  
Ovarian Dysfunction ◽  
Dose Rates ◽  
Highly Sensitive ◽  
Microscopic Evaluation ◽  
Ovarian Pathology ◽  
Normal Offspring

The developing mammalian fetus is thought to be highly sensitive to ionizing radiation. However, dose, dose-rate relationships are not well established, especially the long term effects of protracted, low-dose exposure. A previous report (1) has indicated that bred beagle bitches exposed to daily doses of 5 to 35 R 60Co gamma rays throughout gestation can produce viable, seemingly normal offspring. Puppies irradiated in utero are distinguishable from controls only by their smaller size, dental abnormalities, and, in adulthood, by their inability to bear young.We report here our preliminary microscopic evaluation of ovarian pathology in young pups continuously irradiated throughout gestation at daily (22 h/day) dose rates of either 0.4, 1.0, 2.5, or 5.0 R/day of gamma rays from an attenuated 60Co source. Pups from non-irradiated bitches served as controls. Experimental animals were evaluated clinically and hematologically (control + 5.0 R/day pups) at regular intervals.

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

Long-Term Effects of Head Lice Tx Unknown

2012 ◽  
Vol 43 (3) ◽  
pp. 42
Author(s):  
MITCHEL L. ZOLER
Keyword(s):  
Head Lice ◽  
Long Term Effects
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