Estrogen receptor β signaling regulates the progression of Chinese non-small cell lung cancer

2011 ◽  
Vol 124 (1-2) ◽  
pp. 47-57 ◽  
Author(s):  
Guangfeng Zhao ◽  
Shuli Zhao ◽  
Tingting Wang ◽  
Shihua Zhang ◽  
Kaihua Lu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Estrogen Receptor ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Estrogen Receptor Β ◽  
Small Cell Lung

Highly concordant coexpression of aromatase and estrogen receptor β in non–small cell lung cancer

2010 ◽  
Vol 41 (2) ◽  
pp. 190-198 ◽  
Author(s):  
Keiko Abe ◽  
Yasuhiro Miki ◽  
Katsuhiko Ono ◽  
Miki Mori ◽  
Hideaki Kakinuma ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Estrogen Receptor ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Estrogen Receptor Β ◽  
Small Cell Lung

Increased midkine and estrogen receptor-β expression in human non-small cell lung cancer

2009 ◽  
Vol 21 (4) ◽  
pp. 255-264 ◽  
Author(s):  
Shi-hua Zhang ◽  
Guang-feng Zhao ◽  
Ya-hong Huang ◽  
Kai-hua Lu ◽  
Ya-yi Hou
Keyword(s):  
Lung Cancer ◽  
Estrogen Receptor ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Estrogen Receptor Β ◽  
Small Cell Lung

Estrogen receptor-beta (ER-beta) expression and non-small cell lung cancer (NSCLC) outcome.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. e21092-e21092
Author(s):  
S. Navaratnam ◽  
L. Murphy ◽  
G. Qing ◽  
A. Demers ◽  
G. Skliris ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Estrogen Receptor ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Estrogen Receptor Beta ◽  
Small Cell ◽  
Small Cell Lung ◽  
Receptor Beta

scholarly journals Prognostic and predictive value of estrogen receptor 1 expression in completely resected non-small cell lung cancer

2013 ◽  
Vol 133 (8) ◽  
pp. 1825-1831 ◽  
Author(s):  
Wolfgang Michael Brueckl ◽  
Salah-Eddin Al-Batran ◽  
Joachim Hans Ficker ◽  
Silke Claas ◽  
Akin Atmaca ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Estrogen Receptor ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Predictive Value ◽  
Small Cell ◽  
Small Cell Lung ◽  
Estrogen Receptor 1

scholarly journals CLPTM1L induces estrogen receptor β signaling-mediated radioresistance in non-small cell lung cancer cells

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Hang Li ◽  
Jun Che ◽  
Mian Jiang ◽  
Ming Cui ◽  
Guoxing Feng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Estrogen Receptor ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Target Genes ◽  
Small Cell ◽  
Small Cell Lung

Abstract Introduction Radioresistance is a major challenge in lung cancer radiotherapy, and new radiosensitizers are urgently needed. Estrogen receptor β (ERβ) is involved in the progression of non-small cell lung cancer (NSCLC), however, the role of ERβ in the response to radiotherapy in lung cancer remains elusive. In the present study, we investigated the mechanism underlying ERβ-mediated transcriptional activation and radioresistance of NSCLC cells. Methods Quantitative real-time PCR, western blot and immunohistochemistry were used to detect the expression of CLPTM1L, ERβ and other target genes. The mechanism of CLPTM1L in modulation of radiosensitivity was investigated by chromatin immunoprecipitation assay, luciferase reporter gene assay, immunofluorescence staining, confocal microscopy, coimmunoprecipitation and GST pull-down assays. The functional role of CLPTM1L was detected by function assays in vitro and in vivo. Results CLPTM1L expression was negatively correlated with the radiosensitivity of NSCLC cell lines, and irradiation upregulated CLPTM1L in radioresistant (A549) but not in radiosensitive (H460) NSCLC cells. Meanwhile, IR induced the translocation of CLPTM1L from the cytoplasm into the nucleus in NSCLC cells. Moreover, CLPTM1L induced radioresistance in NSCLC cells. iTRAQ-based analysis and cDNA microarray identified irradiation-related genes commonly targeted by CLPTM1L and ERβ, and CLPTM1L upregulated ERβ-induced genes CDC25A, c-Jun, and BCL2. Mechanistically, CLPTM1L coactivated ERβ by directly interacting with ERβ through the LXXLL NR (nuclear receptor)-binding motif. Functionally, ERβ silencing was sufficient to block CLPTM1L-enhanced radioresistance of NSCLC cells in vitro. CLPTM1L shRNA treatment in combination with irradiation significantly inhibited cancer cell growth in NSCLC xenograft tumors in vivo. Conclusions The present results indicate that CLPTM1L acts as a critical coactivator of ERβ to promote the transcription of its target genes and induce radioresistance of NSCLC cells, suggesting a new target for radiosensitization in NSCLC therapy.

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