The sensor region of the ubiquitous cytosolic sensor kinase, PdtaS, contains PAS and GAF domain sensing modules

2012 ◽  
Vol 177 (2) ◽  
pp. 498-505 ◽  
Author(s):  
Julia Preu ◽  
Santosh Panjikar ◽  
Preben Morth ◽  
Rohan Jaiswal ◽  
Prashantha Karunakar ◽  
...  
Keyword(s):  
Sensor Kinase ◽  
Sensor Region

scholarly journals Evolutionary rewiring: a modified prokaryotic gene-regulatory pathway in chloroplasts

2013 ◽  
Vol 368 (1622) ◽  
pp. 20120260 ◽  
Author(s):  
Sujith Puthiyaveetil ◽  
Iskander M. Ibrahim ◽  
John F. Allen
Keyword(s):  
Green Algae ◽  
Gene Transcription ◽  
Response Regulator ◽  
Regulatory System ◽  
Photosynthetic Electron Transport ◽  
Sensor Kinase ◽  
Ps I ◽  
Component Systems ◽  
Two Component Systems ◽  
Gene Regulatory

Photosynthetic electron transport regulates chloroplast gene transcription through the action of a bacterial-type sensor kinase known as chloroplast sensor kinase (CSK). CSK represses photosystem I (PS I) gene transcription in PS I light and thus initiates photosystem stoichiometry adjustment. In cyanobacteria and in non-green algae, CSK homologues co-exist with their response regulator partners in canonical bacterial two-component systems. In green algae and plants, however, no response regulator partner of CSK is found. Yeast two-hybrid analysis has revealed interaction of CSK with sigma factor 1 (SIG1) of chloroplast RNA polymerase. Here we present further evidence for the interaction between CSK and SIG1. We also show that CSK interacts with quinone. Arabidopsis SIG1 becomes phosphorylated in PS I light, which then specifically represses transcription of PS I genes. In view of the identical signalling properties of CSK and SIG1 and of their interactions, we suggest that CSK is a SIG1 kinase. We propose that the selective repression of PS I genes arises from the operation of a gene-regulatory phosphoswitch in SIG1. The CSK-SIG1 system represents a novel, rewired chloroplast-signalling pathway created by evolutionary tinkering. This regulatory system supports a proposal for the selection pressure behind the evolutionary stasis of chloroplast genes.

scholarly journals Structural basis of thiol-based regulation of formaldehyde detoxification inH. influenzaeby a MerR regulator with no sensor region

2016 ◽  
Vol 44 (14) ◽  
pp. 6981-6993 ◽  
Author(s):  
Rafael M. Couñago ◽  
Nathan H. Chen ◽  
Chiung-Wen Chang ◽  
Karrera Y. Djoko ◽  
Alastair G. McEwan ◽  
...  
Keyword(s):  
Structural Basis ◽  
No Sensor ◽  
Sensor Region

scholarly journals Septal Localization of theMycobacterium tuberculosisMtrB Sensor Kinase Promotes MtrA Regulon Expression

2012 ◽  
Vol 287 (28) ◽  
pp. 23887-23899 ◽  
Author(s):  
Renata Plocinska ◽  
Gorla Purushotham ◽  
Krishna Sarva ◽  
Indumathi S. Vadrevu ◽  
Emmanuel V. P. Pandeeti ◽  
...  
Keyword(s):  
Sensor Kinase ◽  
Septal Localization

scholarly journals Distinct virulence ranges for infection of mice by Bordetella pertussis revealed by engineering of the sensor-kinase BvgS

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0204861 ◽  
Author(s):  
Elodie Lesne ◽  
Loic Coutte ◽  
Luis Solans ◽  
Stephanie Slupek ◽  
Anne-Sophie Debrie ◽  
...  
Keyword(s):  
Bordetella Pertussis ◽  
Sensor Kinase
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