CD74-dysregulation of placental macrophage-trophoblastic interactions in preeclampsia

2016 ◽  
Vol 115 ◽  
pp. 41-42 ◽  
Author(s):  
L. Przybyl ◽  
N. Haase ◽  
M. Golic ◽  
J. Rugor ◽  
M.E. Solano ◽  
...  
Keyword(s):  
Placental Macrophage

scholarly journals Streptococcus agalactiae Induces Placental Macrophages To Release Extracellular Traps Loaded with Tissue Remodeling Enzymes via an Oxidative Burst-Dependent Mechanism

mBio ◽  
2018 ◽  
Vol 9 (6) ◽  
Author(s):  
Ryan S. Doster ◽  
Jessica A. Sutton ◽  
Lisa M. Rogers ◽  
David M. Aronoff ◽  
Jennifer A. Gaddy
Keyword(s):  
Bacterial Infection ◽  
Streptococcus Agalactiae ◽  
Preterm Labor ◽  
Fetal Membrane ◽  
Content Type ◽  
Membrane Rupture ◽  
Extracellular Traps ◽  
Placental Macrophages ◽  
Group B ◽  
Placental Macrophage

ABSTRACT Streptococcus agalactiae, or group B Streptococcus (GBS), is a common perinatal pathogen. GBS colonization of the vaginal mucosa during pregnancy is a risk factor for invasive infection of the fetal membranes (chorioamnionitis) and its consequences such as membrane rupture, preterm labor, stillbirth, and neonatal sepsis. Placental macrophages, or Hofbauer cells, are fetally derived macrophages present within placental and fetal membrane tissues that perform vital functions for fetal and placental development, including supporting angiogenesis, tissue remodeling, and regulation of maternal-fetal tolerance. Although placental macrophages as tissue-resident innate phagocytes are likely to engage invasive bacteria such as GBS, there is limited information regarding how these cells respond to bacterial infection. Here, we demonstrate in vitro that placental macrophages release macrophage extracellular traps (METs) in response to bacterial infection. Placental macrophage METs contain proteins, including histones, myeloperoxidase, and neutrophil elastase similar to neutrophil extracellular traps, and are capable of killing GBS cells. MET release from these cells occurs by a process that depends on the production of reactive oxygen species. Placental macrophage METs also contain matrix metalloproteases that are released in response to GBS and could contribute to fetal membrane weakening during infection. MET structures were identified within human fetal membrane tissues infected ex vivo, suggesting that placental macrophages release METs in response to bacterial infection during chorioamnionitis. IMPORTANCE Streptococcus agalactiae, also known as group B Streptococcus (GBS), is a common pathogen during pregnancy where infection can result in chorioamnionitis, preterm premature rupture of membranes (PPROM), preterm labor, stillbirth, and neonatal sepsis. Mechanisms by which GBS infection results in adverse pregnancy outcomes are still incompletely understood. This study evaluated interactions between GBS and placental macrophages. The data demonstrate that in response to infection, placental macrophages release extracellular traps capable of killing GBS. Additionally, this work establishes that proteins associated with extracellular trap fibers include several matrix metalloproteinases that have been associated with chorioamnionitis. In the context of pregnancy, placental macrophage responses to bacterial infection might have beneficial and adverse consequences, including protective effects against bacterial invasion, but they may also release important mediators of membrane breakdown that could contribute to membrane rupture or preterm labor.

Isolation and characterization of four CSF-1-dependent placental macrophage cell lines

1992 ◽  
Vol 51 (6) ◽  
pp. 535-545 ◽  
Author(s):  
C.A. Boocock ◽  
M. Hayes ◽  
M.-d. Y. Chang ◽  
J.W. Pollard
Keyword(s):  
Cell Lines ◽  
Macrophage Cell ◽  
Isolation And Characterization ◽  
Placental Macrophage

scholarly journals CD74-Downregulation of Placental Macrophage-Trophoblastic Interactions in Preeclampsia

2016 ◽  
Vol 119 (1) ◽  
pp. 55-68 ◽  
Author(s):  
Lukasz Przybyl ◽  
Nadine Haase ◽  
Michaela Golic ◽  
Julianna Rugor ◽  
Maria Emilia Solano ◽  
...  
Keyword(s):  
Placental Macrophage

scholarly journals Role of the Monocyte–Macrophage System in Normal Pregnancy and Preeclampsia

2019 ◽  
Vol 20 (15) ◽  
pp. 3695 ◽  
Author(s):  
Polina Vishnyakova ◽  
Andrey Elchaninov ◽  
Timur Fatkhudinov ◽  
Gennady Sukhikh
Keyword(s):  
Innate Immunity ◽  
Reproductive System ◽  
Normal Pregnancy ◽  
Current Data ◽  
Ovarian Cycle ◽  
Female Reproductive System ◽  
Maternal Body ◽  
Complicated Pregnancy ◽  
Placental Macrophage

The proper functioning of the monocyte–macrophage system, an important unit of innate immunity, ensures the normal course of pregnancy. In this review, we present the current data on the origin of the monocyte–macrophage system and its functioning in the female reproductive system during the ovarian cycle, and over the course of both normal and complicated pregnancy. Preeclampsia is a crucial gestation disorder characterized by pronounced inflammation in the maternal body that affects the work of the monocyte–macrophage system. The effects of inflammation at preeclampsia manifest in changes in monocyte counts and their subset composition, and changes in placental macrophage counts and their polarization. Here we summarize the recent data on this issue for both the maternal organism and the fetus. The influence of estrogen on macrophages and their altered levels in preeclampsia are also discussed.

scholarly journals Characterization of the Placental Macrophage Secretome: Implications for Antiviral Activity

Placenta ◽  
2009 ◽  
Vol 30 (2) ◽  
pp. 149-155 ◽  
Author(s):  
K. García ◽  
V. García ◽  
J. Pérez Laspiur ◽  
F. Duan ◽  
L.M. Meléndez
Keyword(s):  
Antiviral Activity ◽  
Placental Macrophage

scholarly journals Streptococcus agalactiae induces placental macrophages to release extracellular traps loaded with tissue remodeling enzymes via an oxidative-burst-dependent mechanism

2018 ◽  
Author(s):  
Ryan S. Doster ◽  
Jessica A. Sutton ◽  
Lisa M. Rogers ◽  
David M. Aronoff ◽  
Jennifer A. Gaddy
Keyword(s):  
Bacterial Infection ◽  
Streptococcus Agalactiae ◽  
Neonatal Sepsis ◽  
Preterm Labor ◽  
Fetal Membrane ◽  
Membrane Rupture ◽  
Extracellular Traps ◽  
Placental Macrophages ◽  
Group B ◽  
Placental Macrophage

AbstractStreptococcus agalactiae, or Group B Streptococcus (GBS), is a common perinatal pathogen. GBS colonization of the vaginal mucosa during pregnancy is a risk factor for invasive infection of the fetal membranes (chorioamnionitis) and its consequences such as membrane rupture, preterm labor, stillbirth, and neonatal sepsis. Placental macrophages, or Hofbauer cells, are fetally-derived macrophages present within placental and fetal membrane tissues that perform vital functions for fetal and placental development, including supporting angiogenesis, tissue remodeling, and regulation of maternal-fetal tolerance. Although placental macrophages, as tissue-resident innate phagocytes, are likely to engage invasive bacteria such as GBS, there is limited information regarding how these cells respond to bacterial infection. Here, we demonstrate in vitro that placental macrophages release macrophage extracellular traps (METs) in response to bacterial infection. Placental macrophage METs contain proteins including histones, myeloperoxidase, and neutrophil elastase similar to neutrophil extracellular traps and are capable of killing GBS cells. MET release from these cells occurs by a process that depends on the production of reactive oxygen species. Placental macrophage METs also contain matrix metalloproteases that are released in response to GBS and could contribute to fetal membrane weakening during infection. MET structures were identified within human fetal membrane tissues infected ex vivo, suggesting that placental macrophages release METs in response to bacterial infection during chorioamnionitis.ImportanceStreptococcus agalactiae, also known as Group B Streptococcus (GBS), is a common pathogen during pregnancy where infection can result in chorioamnionitis, preterm premature rupture of membranes (PPROM), preterm labor, stillbirth, and neonatal sepsis. Mechanisms by which GBS infection results in adverse pregnancy outcomes are still incompletely understood. This study evaluated interactions between GBS and placental macrophages. The data demonstrate that in response to infection, placental macrophages release extracellular traps capable of killing GBS. Additionally, this work establishes that proteins associated with extracellular trap fibers include several matrix metalloproteinases that have been associated with chorioamnionitis. In the context of pregnancy, placental macrophage responses to bacterial infection might have beneficial and adverse consequences, including protective effects against bacterial invasion but also releasing important mediators of membrane breakdown that could contribute to membrane rupture or preterm labor.

Placental macrophage (Hofbauer cell) polarization is independent of maternal allergen-sensitization and presence of chorioamnionitis

Placenta ◽  
2011 ◽  
Vol 32 (5) ◽  
pp. 380-385 ◽  
Author(s):  
M. Joerink ◽  
E. Rindsjö ◽  
B. van Riel ◽  
J. Alm ◽  
N. Papadogiannakis
Keyword(s):  
Cell Polarization ◽  
Allergen Sensitization ◽  
Placental Macrophage
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