Male fertility and apoptosis in normal spermatogenesis are regulated by vacuolar-ATPase isoform a2

2015 ◽  
Vol 112 ◽  
pp. 38-45 ◽  
Author(s):  
Mukesh K. Jaiswal ◽  
Varkha Agrawal ◽  
Gajendra K. Katara ◽  
Sahithi Pamarthy ◽  
Arpita Kulshrestha ◽  
...  
Keyword(s):  
Male Fertility ◽  
Vacuolar Atpase ◽  
Normal Spermatogenesis

Genetic disorders and spermatogenesis

1998 ◽  
Vol 10 (1) ◽  
pp. 97 ◽  
Author(s):  
R. I. McLachlan ◽  
C. Mallidis ◽  
K. Ma ◽  
S. Bhasin ◽  
D. M. de Kretser
Keyword(s):  
Male Fertility ◽  
Genetic Linkage ◽  
Genetic Basis ◽  
Genetic Disorders ◽  
Genetic Regulation ◽  
Testicular Development ◽  
Paracrine Regulation ◽  
Normal Spermatogenesis ◽  
Cell Mitosis ◽  
Spermatogenic Failure

Male infertility affects one man in twenty and a genetic basis seems likely in at least 30% of those men. Genetic regulation of fertility involves the inter-related processes of testicular development, spermatogenesis (involving germ cell mitosis, meiosis and spermatid maturation), and their endocrine and paracrine regulation. In regard to spermatogenesis, particular attention has been given to the Yq11 region, where some spermatogenesis genes (‘azoospermia factors’) appear to be located. Several candidate genes have been identified but have not been shown to have a defined or essential role in spermatogenesis. Microdeletions of Yq11 are found in ~15% of azoospermic or severely oligospermic men. The complexity of the genetic control of male fertility is demonstrated by the evidence for genes involved in spermatogenesis and sexual differentiation on the X chromosome and autosomes. Better understanding of the genetic regulation of normal spermatogenesis will provide new probes for clinical studies; however, at present the majority of spermatogenic failure remains without an identified genetic linkage. The advent of intracytoplasmic sperm injection permits fertility in many previously sterile men and presents the possibility of their transmission of infertility; appropriate counselling is required.

scholarly journals MECHANISMS IN ENDOCRINOLOGY: Hormonal regulation of spermatogenesis: mutant mice challenging old paradigms

2018 ◽  
Vol 179 (3) ◽  
pp. R143-R150 ◽  
Author(s):  
Ilpo Huhtaniemi
Keyword(s):  
Sertoli Cells ◽  
Hormonal Regulation ◽  
Male Fertility ◽  
Knockout Mouse ◽  
Double Mutant ◽  
Follicle Stimulating Hormone ◽  
Mutant Mice ◽  
Lh Receptor ◽  
Androgen Action ◽  
Normal Spermatogenesis

The two pituitary gonadotrophins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and in particular LH-stimulated high intratesticular testosterone (ITT) concentration, are considered crucial for spermatogenesis. We have revisited these concepts in genetically modified mice, one being theLH receptor(R)-knockout mouse (LuRKO), the other a transgenic mouse expressing in Sertoli cells a highly constitutively active mutatedFshr(Fshr-CAM). It was found that full spermatogenesis was induced by exogenous testosterone treatment in LuRKO mice at doses that restored ITT concentration to a level corresponding to the normal circulating testosterone level in WT mice, ≈5 nmol/L, which is 1.4% of the normal high ITT concentration. When hypogonadal LuRKO and Fshr-CAM mice were crossed, the double-mutant mice with strong FSH signaling, but minimal testosterone production, showed near-normal spermatogenesis, even when their residual androgen action was blocked with the strong antiandrogen flutamide. In conclusion, our findings challenge two dogmas of the hormonal regulation of male fertility: (1) high ITT concentration is not necessary for spermatogenesis and (2) strong FSH stimulation can maintain spermatogenesis without testosterone. These findings have clinical relevance for the development of hormonal male contraception and for the treatment of idiopathic oligozoospermia.

scholarly journals PPP1CC2 levels are highly regulated in testis to ensure normal spermatogenesis and male fertility

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Shuvalaxmi Dasgupta ◽  
Nilam Sinha ◽  
Srinivasan Vijayaraghavan
Keyword(s):  
Male Fertility ◽  
Normal Spermatogenesis

Vacuolar ATPase subunit a2 expression is associated with normal spermatogenesis in mice

2012 ◽  
Vol 94 (1) ◽  
pp. 76-77
Author(s):  
B.K. Kolli ◽  
M. Jaiswal ◽  
A. Gilman-Sachs ◽  
K. Beaman
Keyword(s):  
Vacuolar Atpase ◽  
Atpase Subunit ◽  
Normal Spermatogenesis

scholarly journals Vacuolar-ATPase isoform a2 regulates macrophages and cytokine profile necessary for normal spermatogenesis in testis

2014 ◽  
Vol 96 (2) ◽  
pp. 337-347 ◽  
Author(s):  
M. K. Jaiswal ◽  
G. K. Katara ◽  
T. Mallers ◽  
G. Chaouat ◽  
A. Gilman-Sachs ◽  
...  
Keyword(s):  
Vacuolar Atpase ◽  
Cytokine Profile ◽  
Normal Spermatogenesis

scholarly journals RDC complex executes a dynamic piRNA program during Drosophila spermatogenesis to safeguard male fertility

2020 ◽  
Author(s):  
Peiwei Chen ◽  
Yicheng Luo ◽  
Alexei A. Aravin
Keyword(s):  
Germ Cells ◽  
Male Fertility ◽  
Germline Stem Cells ◽  
Male Germline ◽  
Pirna Cluster ◽  
Transposon Silencing ◽  
Normal Spermatogenesis ◽  
Non Coding Rnas ◽  
Female Germline ◽  
Active Genes

SUMMARYpiRNAs are small non-coding RNAs that guide the silencing of transposons and other targets in animal gonads. In Drosophila female germline, many piRNA source loci dubbed ‘piRNA clusters’ lack hallmarks of active genes and exploit an alternative path for transcription, which relies on the Rhino-Deadlock-Cutoff (RDC) complex. It remains to date unknown how piRNA cluster transcription is regulated in the male germline. We found that components of RDC complex are expressed in male germ cells during early spermatogenesis, from germline stem cells (GSCs) to early spermatocytes. RDC is essential for expression of dual-strand piRNA clusters and transposon silencing in testis; however, it is dispensable for expression of Y-linked Suppressor of Stellate piRNAs and therefore Stellate silencing. Despite intact Stellate repression, rhi mutant males exhibited compromised fertility accompanied by germline DNA damage and GSC loss. Thus, piRNA-guided repression is essential for normal spermatogenesis beyond Stellate silencing. While RDC associates with multiple piRNA clusters in GSCs and early spermatogonia, its localization changes in later stages as RDC concentrates on a single X-linked locus, AT-chX. Dynamic RDC localization is paralleled by changes in piRNA cluster expression, indicating that RDC executes a fluid piRNA program during different stages of spermatogenesis.

Suppression of spermatogenesis by exogenous testosterone

2020 ◽  
Vol 26 ◽  
Author(s):  
Ferdinando Fusco ◽  
Paolo Verze ◽  
Marco Capece ◽  
Luigi Napolitano
Keyword(s):  
Male Fertility ◽  
Leydig Cells ◽  
Sperm Count ◽  
Sperm Concentration ◽  
Seminiferous Tubules ◽  
Sperm Production ◽  
Long Term Effects ◽  
Fertility Status ◽  
Normal Spermatogenesis

: Sperm production starts from puberty in the seminiferous tubules providing for testosterone production by the Leydig cells taking place in the interstice of the testicles. Normal spermatogenesis depends on specific signalling from the hypothalamic-pituitary-gonadal axis. GnRH, FSH and LH are the main hormones involved in the production and maturation of spermatozoa. Exogenous administration of androgens influences the hypothalamic-pituitary-gonadal axis with negative feedback that may lead to partial or complete cessation of spermatogenesis by decreasing FSH and LH. Despite the fact that many trials have confirmed that exogenous testosterone affects male fertility status, evidence regarding the long-term effects of treatment is conflicting. Regarding this aspect, many studies have confirmed a return to baseline sperm concentration after testosterone treatment discontinuation, however none of them can specify how long recovery will take nor whether the sperm count is sufficient for fertility.

Effect of new dietary supplement on sperm quality

2012 ◽  
Vol 153 (45) ◽  
pp. 1787-1792 ◽  
Author(s):  
Mária Horváth ◽  
Endre Czeizel
Keyword(s):  
Adverse Effect ◽  
Clinical Trial ◽  
Dietary Supplement ◽  
Male Fertility ◽  
Sperm Quality ◽  
Sperm Count ◽  
Before And After ◽  
The Usa ◽  
New Treatments

Introduction: There is a decline in male fertility thus new treatments are needed. Aims: To test the efficacy of a new dietary supplement developed in the USA and registered as a curing drug in Hungary (OGYI). Methods: In a clinical trial 100 men with low sperm quality (spermium count 5–20 M/ml, good motility 10–40%, and adverse shape 30–50%) were examined. Results: Sperm parameters were measured before and after a 3-month treatment and after another 3-month without treatment. This dietary supplement statistically and clinically significantly improved sperm count and motility. In 74 cases this dietary supplement demonstrated a beneficial effect on sperm quality (more than 10% increase in sperm count, or quality of motility, or shape); in 16 cases the improvement exceeded 30%. No adverse effect could be accounted for this treatment. Conclusions: This new dietary supplement may contribute to the treatment of male infertility. Orv. Hetil., 2012, 153, 1787–1792.

Sign in / Sign up

Export Citation Format

Share Document