Influenza A virus infection during pregnancy: an impaired interaction between dendritic cells and the adaptive immune system reduces specific killing of infected cells in mice

2014 ◽  
Vol 101-102 ◽  
pp. 41
Author(s):  
René Thieme ◽  
Julia Hoffmann ◽  
Géraldine L. Engels ◽  
Hans-Willi Mittrücker ◽  
Khalil Karimi ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Immune System ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Adaptive Immune System ◽  
Adaptive Immune ◽  
Infected Cells ◽  
Influenza A Virus Infection

scholarly journals Dicer is involved in protection against influenza A virus infection

2007 ◽  
Vol 88 (10) ◽  
pp. 2627-2635 ◽  
Author(s):  
Alexey A. Matskevich ◽  
Karin Moelling
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Mammalian Cells ◽  
Influenza A ◽  
Virus Production ◽  
Vero Cells ◽  
Antiviral Response ◽  
Protein Levels ◽  
Infected Cells ◽  
Influenza A Virus Infection

In mammals the interferon (IFN) system is a central innate antiviral defence mechanism, while the involvement of RNA interference (RNAi) in antiviral response against RNA viruses is uncertain. Here, we tested whether RNAi is involved in the antiviral response in mammalian cells. To investigate the role of RNAi in influenza A virus-infected cells in the absence of IFN, we used Vero cells that lack IFN-α and IFN-β genes. Our results demonstrate that knockdown of a key RNAi component, Dicer, led to a modest increase of virus production and accelerated apoptosis of influenza A virus-infected cells. These effects were much weaker in the presence of IFN. The results also show that in both Vero cells and the IFN-producing alveolar epithelial A549 cell line influenza A virus targets Dicer at mRNA and protein levels. Thus, RNAi is involved in antiviral response, and Dicer is important for protection against influenza A virus infection.

scholarly journals Dendritic cells and influenza A virus infection

Virulence ◽  
2012 ◽  
Vol 3 (7) ◽  
pp. 603-608 ◽  
Author(s):  
Jason Waithman ◽  
Justine D. Mintern
Keyword(s):  
Dendritic Cells ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Influenza A Virus Infection

scholarly journals Increased Proinflammatory Responses of Monocytes and Plasmacytoid Dendritic Cells to Influenza A Virus Infection During Pregnancy

2016 ◽  
Vol 214 (11) ◽  
pp. 1666-1671 ◽  
Author(s):  
Mathieu Le Gars ◽  
Alexander W. Kay ◽  
Nicholas L. Bayless ◽  
Natali Aziz ◽  
Cornelia L. Dekker ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Plasmacytoid Dendritic Cells ◽  
Proinflammatory Responses ◽  
Influenza A Virus Infection

scholarly journals Proton Channel Activity of Influenza A Virus Matrix Protein 2 Contributes to Autophagy Arrest

2015 ◽  
Vol 90 (1) ◽  
pp. 591-598 ◽  
Author(s):  
Yizhong Ren ◽  
Chufang Li ◽  
Liqiang Feng ◽  
Weiqi Pan ◽  
Liang Li ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Matrix Protein ◽  
Proton Channel ◽  
Channel Activity ◽  
Infected Cells ◽  
Influenza A Virus Infection ◽  
M2 Proton Channel

Influenza A virus infection can arrest autophagy, as evidenced by autophagosome accumulation in infected cells. Here, we report that this autophagosome accumulation can be inhibited by amantadine, an antiviral proton channel inhibitor, in amantadine-sensitive virus infected cells or cells expressing influenza A virus matrix protein 2 (M2). Thus, M2 proton channel activity plays a role in blocking the fusion of autophagosomes with lysosomes, which might be a key mechanism for arresting autophagy.

scholarly journals Dendritic cells are associated with augmentation of antigen sensitization by influenza A virus infection in mice

2000 ◽  
Vol 30 (1) ◽  
pp. 316-326 ◽  
Author(s):  
Naomi Yamamoto ◽  
Shunsuke Suzuki ◽  
Akira Shirai ◽  
Motoyoshi Suzuki ◽  
Masatoshi Nakazawa ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Influenza A Virus Infection

scholarly journals Influenza A Virus Infection of Human Primary Dendritic Cells Impairs Their Ability to Cross-Present Antigen to CD8 T Cells

2012 ◽  
Vol 8 (3) ◽  
pp. e1002572 ◽  
Author(s):  
Anna Smed-Sörensen ◽  
Cécile Chalouni ◽  
Bithi Chatterjee ◽  
Lillian Cohn ◽  
Peter Blattmann ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Cd8 T Cells ◽  
Influenza A ◽  
Influenza A Virus Infection
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