Vascular endothelial growth factor-A gene polymorphisms in women with recurrent pregnancy loss

2011 ◽  
Vol 88 (1) ◽  
pp. 48-52 ◽  
Author(s):  
Alexandra G. Eller ◽  
D. Ware Branch ◽  
Lesa Nelson ◽  
T. Flint Porter ◽  
Robert M. Silver
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Gene Polymorphisms ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Vascular Endothelial ◽  
Endothelial Growth Factor

scholarly journals Vascular endothelial growth factor gene polymorphisms and idiopathic recurrent pregnancy loss

2005 ◽  
Vol 83 (4) ◽  
pp. 959-963 ◽  
Author(s):  
Dimitrios Papazoglou ◽  
Georgios Galazios ◽  
Konstantinos Papatheodorou ◽  
Vasilios Liberis ◽  
Nikolaos Papanas ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Gene Polymorphisms ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Vascular Endothelial ◽  
Factor Gene ◽  
Growth Factor Gene ◽  
Endothelial Growth Factor

scholarly journals 3′-UTR Polymorphisms in the Vascular Endothelial Growth Factor Gene (VEGF) Contribute to Susceptibility to Recurrent Pregnancy Loss (RPL)

2019 ◽  
Vol 20 (13) ◽  
pp. 3319 ◽  
Author(s):  
Hui Jeong An ◽  
Ji Hyang Kim ◽  
Eun Hee Ahn ◽  
Young Ran Kim ◽  
Jung Oh Kim ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Vascular Endothelial ◽  
Nucleotide Polymorphisms ◽  
Allelic Discrimination ◽  
Genotype Frequencies ◽  
Growth Factor Gene ◽  
Endothelial Growth Factor

Numerous studies have examined the genetic association of vascular endothelial growth factor (VEGF) single nucleotide polymorphisms (SNPs) with recurrent pregnancy loss (RPL). However, of the four known SNPs in the 3′-untranslated region (3′-UTR) of VEGF, three SNPs—namely rs3025040 (1451C>T), rs10434 (1612G>A), and rs3025053 (1725G>A)—remain poorly characterized with regard to RPL. Herein, we evaluated the association between these three SNPs in the VEGF 3′-UTR and RPL susceptibility. We analyzed VEGF 3′-UTR gene variants in with and without RPL using TaqMan allelic discrimination. There were significant differences in the genotype frequencies of 1612G>A (GA: adjusted odds ratio (AOR), 0.652; 95% confidence interval (CI), 0.447–0.951; p = 0.026) and 1725G>A (GA: AOR, 0.503; 95% CI, 0.229–0.848; p = 0.010) in RPL patients vs. controls. Our results indicate that the 1612G>A and 1725G>A polymorphisms in the 3′-UTR of VEGF are associated with RPL susceptibility in Korean women. These data suggest that VEGF 3′-UTR polymorphisms may be utilized as biomarkers for the detection of RPL risk and prevention.

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