Utilising T cell receptor transgenic mice to define mechanisms of maternal T cell tolerance in pregnancy

2010 ◽  
Vol 87 (1-2) ◽  
pp. 1-13 ◽  
Author(s):  
Lachlan M. Moldenhauer ◽  
John D. Hayball ◽  
Sarah A. Robertson
Keyword(s):  
T Cell ◽  
Transgenic Mice ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
T Cell Tolerance ◽  
Cell Tolerance ◽  
In Pregnancy

T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.

1989 ◽  
Vol 8 (3) ◽  
pp. 719-727 ◽  
Author(s):  
H. Pircher ◽  
T. W. Mak ◽  
R. Lang ◽  
W. Ballhausen ◽  
E. Rüedi ◽  
...  
Keyword(s):  
T Cell ◽  
Transgenic Mice ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
T Cell Tolerance ◽  
Cell Tolerance

scholarly journals Peripheral CD8+ T Cell Tolerance to Self-Proteins Is Regulated Proximally at the T Cell Receptor

Immunity ◽  
2008 ◽  
Vol 28 (5) ◽  
pp. 662-674 ◽  
Author(s):  
Ryan M. Teague ◽  
Philip D. Greenberg ◽  
Carla Fowler ◽  
Maria Z. Huang ◽  
Xiaoxia Tan ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cd8 T Cell ◽  
Cell Receptor ◽  
T Cell Tolerance ◽  
Cell Tolerance

scholarly journals The E3 Ubiquitin Ligase GRAIL Regulates T Cell Tolerance and Regulatory T Cell Function by Mediating T Cell Receptor-CD3 Degradation

Immunity ◽  
2010 ◽  
Vol 32 (5) ◽  
pp. 670-680 ◽  
Author(s):  
Roza I. Nurieva ◽  
Shuling Zheng ◽  
Wei Jin ◽  
Yeonseok Chung ◽  
Yongliang Zhang ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Ubiquitin Ligase ◽  
Regulatory T Cell ◽  
Cell Function ◽  
E3 Ubiquitin Ligase ◽  
Cell Receptor ◽  
T Cell Tolerance ◽  
Cell Tolerance ◽  
T Cell Function

scholarly journals Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance

Cell ◽  
2014 ◽  
Vol 159 (2) ◽  
pp. 333-345 ◽  
Author(s):  
Ondrej Stepanek ◽  
Arvind S. Prabhakar ◽  
Celine Osswald ◽  
Carolyn G. King ◽  
Anna Bulek ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
T Cell Tolerance ◽  
Cell Tolerance

scholarly journals Strength and Numbers: The Role of Affinity and Avidity in the ‘Quality’ of T Cell Tolerance

Cells ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1530
Author(s):  
Sébastien This ◽  
Stefanie F. Valbon ◽  
Marie-Ève Lebel ◽  
Heather J. Melichar
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Regulatory T Cell ◽  
Cell Receptor ◽  
Cell Populations ◽  
T Cell Tolerance ◽  
Receptor Signaling ◽  
Cell Tolerance

The ability of T cells to identify foreign antigens and mount an efficient immune response while limiting activation upon recognition of self and self-associated peptides is critical. Multiple tolerance mechanisms work in concert to prevent the generation and activation of self-reactive T cells. T cell tolerance is tightly regulated, as defects in these processes can lead to devastating disease; a wide variety of autoimmune diseases and, more recently, adverse immune-related events associated with checkpoint blockade immunotherapy have been linked to a breakdown in T cell tolerance. The quantity and quality of antigen receptor signaling depend on a variety of parameters that include T cell receptor affinity and avidity for peptide. Autoreactive T cell fate choices (e.g., deletion, anergy, regulatory T cell development) are highly dependent on the strength of T cell receptor interactions with self-peptide. However, less is known about how differences in the strength of T cell receptor signaling during differentiation influences the ‘function’ and persistence of anergic and regulatory T cell populations. Here, we review the literature on this subject and discuss the clinical implications of how T cell receptor signal strength influences the ‘quality’ of anergic and regulatory T cell populations.

Sign in / Sign up

Export Citation Format

Share Document