scholarly journals Integrative proteomic analysis reveals reprograming tumor necrosis factor signaling in epithelial mesenchymal transition

2016 ◽  
Vol 148 ◽  
pp. 126-138 ◽  
Author(s):  
Yingxin Zhao ◽  
Bing Tian ◽  
Rovshan G. Sadygov ◽  
Yueqing Zhang ◽  
Allan R. Brasier
Keyword(s):  
Tumor Necrosis Factor ◽  
Proteomic Analysis ◽  
Tumor Necrosis ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Tumor Necrosis Factor Signaling ◽  
Necrosis Factor

Tumor necrosis factor-α modulates epithelial mesenchymal transition mediators ZEB2 and S100A4 to promote cholangiocarcinoma progression

2014 ◽  
Vol 21 (9) ◽  
pp. 703-711 ◽  
Author(s):  
Anchalee Techasen ◽  
Nisana Namwat ◽  
Watcharin Loilome ◽  
Kassaporn Duangkumpha ◽  
Anucha Puapairoj ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Factor Α ◽  
Necrosis Factor

Tumor necrosis factor-α (TNF-α) stimulates the epithelial–mesenchymal transition regulator Snail in cholangiocarcinoma

2012 ◽  
Vol 29 (5) ◽  
pp. 3083-3091 ◽  
Author(s):  
Anchalee Techasen ◽  
Nisana Namwat ◽  
Watcharin Loilome ◽  
Pornpan Bungkanjana ◽  
Narong Khuntikeo ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

Interleukin-6, Tumor Necrosis Factor-α Expression Levels in Prostate Cancer Tissues and Their Effects on Epithelial Interstitial Transformation, Migration and Invasion in Prostate Cancer Cells

2020 ◽  
Vol 10 (12) ◽  
pp. 1773-1779
Author(s):  
Desheng Li ◽  
Shanbin Zhang ◽  
Minfang Zuo ◽  
Xinming Hu ◽  
Shuming He
Keyword(s):  
Prostate Cancer ◽  
Tumor Necrosis Factor ◽  
Cancer Cells ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Epithelial Mesenchymal Transition ◽  
Migration And Invasion ◽  
Prostate Cancer Cells ◽  
Mesenchymal Transition ◽  
Necrosis Factor

Background: To investigate the expression of Interleukin-6, Interleukin-6 in prostate cancer tissues and its effect on migration and evasiveness of cancer cells. Material and Methods: The releasing of Interleukin-6, Tumor necrosis factor-α in prostate cancer cells was detected by ELISA method. For prostate cancer cells after knockout, additional Interleukin-6 or Tumor necrosis factor-α induction was given in vitro. After 12 h of culture, the effects of Interleukin-6, Tumor necrosis factor-α on the migration and evasiveness of prostate cancer cells were observed by Western blot method and matrices invasion experiment. Results: The expression of epithelial mesenchymal transition-related proteins, the migration and invasion ability of prostate cancer cells in each gene knockout group were significantly reduced. After induction of inflammatory factors (Interleukin-6 or Tumor necrosis factor-α) in the gene knockout group for 12 h, the expression levels of epithelial mesenchymal transition-related proteins, the migration and aggressiveness of prostate cancer were significantly higher than those after knockout. Conclusion: Interleukin-6 and Tumor necrosis factor-α can induce epithelial mesenchymal transition in LNCaP and PC3 cells, promote cell invasion and metastasis, and provide a new direction for future research.

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