scholarly journals Meta-markers for the differential diagnosis of lung cancer and lung disease

2016 ◽  
Vol 148 ◽  
pp. 36-43 ◽  
Author(s):  
Yong-In Kim ◽  
Jung-Mo Ahn ◽  
Hye-Jin Sung ◽  
Sang-Su Na ◽  
Jaesung Hwang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Differential Diagnosis ◽  
Lung Disease ◽  
Diagnosis Of Lung Cancer

Clinical value of tumor-associated antigens and autoantibody panel combination detection in the early diagnostic of lung cancer

2021 ◽  
pp. 1-9
Author(s):  
Renren Ouyang ◽  
Shiji Wu ◽  
Bo Zhang ◽  
Ting Wang ◽  
Botao Yin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lung Disease ◽  
Cytokeratin 19 ◽  
Healthy Controls ◽  
Control Groups ◽  
Clinical Value ◽  
Tumor Associated Antigens ◽  
Pathological Subtype ◽  
Positive Rate ◽  
Diagnosis Of Lung Cancer

BACKGROUND: This study aimed to investigate the efficiency of combining tumor-associated antigens (TAAs) and autoantibodies in the diagnosis of lung cancer. METHODS: The serum levels of TAAs and seven autoantibodies (7-AABs) were detected from patients with lung cancer, benign lung disease and healthy controls. The performance of a new panel by combing TAAs and 7-AABs was evaluated for the early diagnosis of lung cancer. RESULTS: The positive rate of 7-AABs was higher than the single detection of antibody. The positive rate of the combined detection of 7-AABs in lung cancer group (30.2%) was significantly higher than that of healthy controls (16.8%), but had no statistical difference compared with that of benign lung disease group (20.8%). The positive rate of 7-AABs showed a tendency to increase in lung cancer patients with higher tumor-node-metastasis (TNM) stages. For the pathological subtype analysis, the positive rate of 7-AABs was higher in patients with squamous cell carcinoma and small cell lung cancer than that of adenocarcinoma. The levels of carcinoembryonic antigen (CEA) and cytokeratin 19 fragment 211 (CYFRA 211) were significantly higher than that of benign lung disease and healthy control groups. An optimal model was established (including 7-AABs, CEA and CYFRA21-1) to distinguish lung cancer from control groups. The performance of this model was superior than that of single markers, with a sensitivity of 52.26% and specificity of 77.46% in the training group. Further assessment was studied in another validation group, with a sensitivity of 44.02% and specificity of 83%. CONCLUSIONS: The diagnostic performance was enhanced by combining 7-AABs, CEA and CYFRA21-1, which has critical value for the screening and early detection of lung cancer.

Comparison of Differential Diagnosis of Lung Cancer by Diffuse Weighted Imaging and Sagittal Imaging with Short Inversion Recovery Sequence

2021 ◽  
Vol 11 (3) ◽  
pp. 822-826
Author(s):  
Wei Zhang ◽  
Qingyu Cai ◽  
Guoli Wei
Keyword(s):  
Lung Cancer ◽  
Differential Diagnosis ◽  
Squamous Cell ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Recovery Sequence ◽  
Cell Lung Carcinoma ◽  
Diagnosis Of Lung Cancer

The differential diagnosis of advanced lung cancer is difficult in clinical practice. Our study aims to compare the value of diffusion weighted imaging (DWI) with short-term inversion recovery sequence (STIR) for sagittal imaging in the differential diagnosis of lung cancer. 149 patients with non-small cell lung carcinoma (NSCLC) were enrolled and underwent DWI and STIR sagittal imaging. To quantify cancer types, we evaluated the apparent diffusion coefficient (ADC) value on DWI and the contrast ratio (CRs) on sagittal imaging. The ADC values of subclasses in NSCLC were significantly higher than small cell lung carcinoma (SCLC) (p <0.01). The mean CRs were 1.59 for SCLC and 1.30 for NSCLC with a significant difference (p < 0.01). Large cell carcinomas (LCC) and adenocarcinomas have significant differences compared to small cell carcinomas (SCC) without difference between squamous cell carcinomas (p > 0.05); this is also the case for CRs. Squamous cell carcinoma and adenocarcinoma have significant differences compared to SCC without difference in LCC (p > 0.05). Qualitative evaluation of the feasible thresholds DWI and STIR showed that the thresholds were 0.9810−3 mm2/s and 1.37 respectively. The specificity and accuracy was 78.5% is 85.3% for DWI, which was significantly higher than STIR (56.3% and 61.0%). The combination of DWI and STIR sequences was superior to DWI alone with an accuracy rate of 94.3%. DWI is more helpful than STIR in differentiating SCLC and NSCLC, and their combined use can significantly improve diagnosis accuracy.

scholarly journals From suspicion of angioedema to the diagnosis of lung cancer

Oncoreview ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 108-112
Author(s):  
Łukasz Moos ◽  
Wojciech Żurek ◽  
Katarzyna Kapeluszna ◽  
Zenon Brzoza
Keyword(s):  
Lung Cancer ◽  
Differential Diagnosis ◽  
Superior Vena Cava Syndrome ◽  
Superior Vena ◽  
Vena Cava ◽  
Small Cell ◽  
Case Presentation ◽  
Facial Swelling ◽  
Vena Cava Syndrome ◽  
Diagnosis Of Lung Cancer

Angioedema is a localized and self-limiting oedema of the subcutaneous and submucosal tissue. Case presentation: 73-year-old man was admitted to the Division of Allergology with the diagnosis of angioedema. Detailed physical examination led to the suspicion of superior vena cava syndrome with secondary face swelling. Biopsy revealed metastasis of small cell carcinoma in superclavicular lymph nodes. Conclusions: Facial swelling, especially recurrent and non-inflammatory, is often, but not always caused by angioedema. Insightful differential diagnosis is crucial before making the final one.

Quantitative analysis for differential diagnosis of lung cancer on blood vessel connectivity using thoracic 3D CT images

2000 ◽  
Author(s):  
Akira Tanaka ◽  
Tetsuya Tozaki ◽  
Yoshiki Kawata ◽  
Noboru Niki ◽  
Hironobu Ohmatsu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Differential Diagnosis ◽  
Quantitative Analysis ◽  
Blood Vessel ◽  
Ct Images ◽  
3D Ct ◽  
Diagnosis Of Lung Cancer

Implications for Differential Diagnosis of Lung Cancer–Associated Lymphadenopathy in Lymphoepithelioid Cell Lymphoma (Lennert’s Lymphoma) Arising Simultaneously with Lung Cancer

2010 ◽  
Vol 54 (2) ◽  
pp. 197-201 ◽  
Author(s):  
Rira Hoshi ◽  
Noriyuki Furuta ◽  
Takeshi Horai ◽  
Kengo Takeuchi ◽  
Yuichi Ishikawa ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Differential Diagnosis ◽  
Cell Lymphoma ◽  
Diagnosis Of Lung Cancer
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