Alteration of protein glycosylation in human hepatic stellate cells activated with transforming growth factor-β1

2012 ◽  
Vol 75 (13) ◽  
pp. 4114-4123 ◽  
Author(s):  
Yannan Qin ◽  
Yaogang Zhong ◽  
Liuyi Dang ◽  
Minzhi Zhu ◽  
Hanjie Yu ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatic Stellate Cells ◽  
Transforming Growth Factor ◽  
Stellate Cells ◽  
Transforming Growth Factor Β1 ◽  
Protein Glycosylation

scholarly journals Profiling of Concanavalin A-Binding Glycoproteins in Human Hepatic Stellate Cells Activated with Transforming Growth Factor-β1

Molecules ◽  
2014 ◽  
Vol 19 (12) ◽  
pp. 19845-19867 ◽  
Author(s):  
Yannan Qin ◽  
Yaogang Zhong ◽  
Ganglong Yang ◽  
Tianran Ma ◽  
Liyuan Jia ◽  
...  
Keyword(s):  
Growth Factor ◽  
Concanavalin A ◽  
Hepatic Stellate Cells ◽  
Transforming Growth Factor ◽  
Stellate Cells ◽  
Transforming Growth Factor Β1

Prostaglandin E2 inhibits transforming growth factor β1-mediated induction of collagen α1(I) in hepatic stellate cells

2004 ◽  
Vol 41 (2) ◽  
pp. 251-258 ◽  
Author(s):  
Alex Y. Hui ◽  
Andrew J. Dannenberg ◽  
Joseph J.Y. Sung ◽  
Kotha Subbaramaiah ◽  
Baoheng Du ◽  
...  
Keyword(s):  
Growth Factor ◽  
Prostaglandin E2 ◽  
Hepatic Stellate Cells ◽  
Transforming Growth Factor ◽  
Stellate Cells ◽  
Transforming Growth Factor Β1

scholarly journals Tanshinone IIA alters the transforming growth factor-β1/Smads pathway in angiotensin II-treated rat hepatic stellate cells

2020 ◽  
Vol 48 (6) ◽  
pp. 030006052092635
Author(s):  
Guo-wei Wei ◽  
Ke-yue Li ◽  
Ke-li Tang ◽  
Cheng-Xian Shi
Keyword(s):  
Angiotensin Ii ◽  
Growth Factor ◽  
Protein Expression ◽  
Hepatic Stellate Cells ◽  
Transforming Growth Factor ◽  
Stellate Cells ◽  
Transforming Growth Factor Β1 ◽  
Tanshinone Iia ◽  
Mrna And Protein Expression ◽  
Tgf Β1

Objective To investigate the effects of tanshinone IIA on the transforming growth factor-β1 (TGF-β1)/Smads signaling pathway in angiotensin II-treated hepatic stellate cells (HSCs). Methods HSCs were cultured and treated with angiotensin II (10 μM) or angiotensin II (10 μM) plus tanshinone IIA (3, 10, or 30 μM). Cells were incubated for 48 hours and proliferation was determined with the Cell Counting Kit-8. The relative mRNA expression of TGF-β1, Smad4, and Smad7 was measured by quantitative real-time PCR, and the relative protein expression levels were investigated by western blotting. Results After angiotensin II treatment, cell proliferation was significantly accelerated. Furthermore, both the mRNA and protein expression of TGF-β1 and Smad4 was significantly up-regulated, while the mRNA and protein expression of Smad7 was significantly down-regulated compared with the control cells. Tanshinone IIA inhibited the observed effects of angiotensin II in a concentration-dependent manner, with significant inhibition exerted by tanshinone IIA at 10 and 30 μM. Conclusions Angiotensin II promotes the proliferation of HSCs, possibly by regulating the expression of components along the TGF-β1/Smads signaling pathway. Tanshinone IIA inhibits the angiotensin II-induced activation of this pathway, and may, therefore, have preventive and therapeutic effects in liver fibrosis.

scholarly journals The Role of Hepatic Stellate Cells and Transforming Growth Factor-β1 in Cystic Fibrosis Liver Disease

2002 ◽  
Vol 160 (5) ◽  
pp. 1705-1715 ◽  
Author(s):  
Peter J. Lewindon ◽  
Tamara N. Pereira ◽  
Anita C. Hoskins ◽  
Kim R. Bridle ◽  
Richard M. Williamson ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Liver Disease ◽  
Growth Factor ◽  
Hepatic Stellate Cells ◽  
Transforming Growth Factor ◽  
Stellate Cells ◽  
Transforming Growth Factor Β1

scholarly journals Transforming growth factor-β1 reduces apoptosis via autophagy activation in hepatic stellate cells

2014 ◽  
Vol 10 (3) ◽  
pp. 1282-1288 ◽  
Author(s):  
MEI-YA FU ◽  
YA-JUN HE ◽  
XIA LV ◽  
ZHI-HE LIU ◽  
YAN SHEN ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatic Stellate Cells ◽  
Transforming Growth Factor ◽  
Stellate Cells ◽  
Transforming Growth Factor Β1
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