Effect of acid stress on protein expression and phosphorylation in Lactobacillus rhamnosus GG

2012 ◽  
Vol 75 (4) ◽  
pp. 1357-1374 ◽  
Author(s):  
Johanna Koponen ◽  
Kati Laakso ◽  
Kerttu Koskenniemi ◽  
Matti Kankainen ◽  
Kirsi Savijoki ◽  
...  
Keyword(s):  
Protein Expression ◽  
Lactobacillus Rhamnosus ◽  
Acid Stress ◽  
Lactobacillus Rhamnosus Gg

scholarly journals Lactobacillus rhamnosus GG Protects the Epithelial Barrier of Wistar Rats from the Pepsin-Trypsin-Digested Gliadin (PTG)-Induced Enteropathy

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1698 ◽  
Author(s):  
Antonella Orlando ◽  
Michele Linsalata ◽  
Giusy Bianco ◽  
Maria Notarnicola ◽  
Benedetta D’Attoma ◽  
...  
Keyword(s):  
Protein Expression ◽  
Wistar Rats ◽  
Lactobacillus Rhamnosus ◽  
Intercellular Junction ◽  
In Vivo Studies ◽  
Polyamine Metabolism ◽  
Protective Effects ◽  
Lactobacillus Rhamnosus Gg ◽  
Junction Protein

Celiac disease (CD) is a chronic immune-mediated disorder, characterized by enhanced paracellular permeability across the intestinal epithelium. The complex system of intercellular junctions, including tight junctions (TJs) and adherens junctions (AJs), seals together the epithelial cells to form a continuous layer. The improvements in barrier integrity have been related to modifications in intercellular junction protein expression. Polyamines (spermidine, spermine, and putrescine) actively participate in the modulation of the AJ expression. Both in vitro and in vivo studies have demonstrated that also probiotics can promote the integrity and the function of the intestinal barrier. On these bases, the present work investigated the protective effects exerted by Lactobacillus rhamnosus GG (L.GG) against the pepsin-trypsin-digested gliadin (PTG)-induced enteropathy in jejunal tissue samples of Wistar rats. In particular, the probiotic effects have been evaluated on the intestinal mucosal architecture, polyamine metabolism and intercellular junction protein expression (ZO-1, Occludin, Claudin-1, β-catenin and E-cadherin). The results from this study indicate that L.GG protects the intestinal mucosa of rats from PTG-induced damage, by preventing the reduction of the expression of the intercellular junction proteins. Consequently, a role for L.GG in the therapeutic management of the gluten-related disorders in humans could be hypothesized.

scholarly journals Lactobacillus rhamnosus GG orchestrates an anti-tumor immune response

2021 ◽  
Author(s):  
Joshua A. Owens ◽  
Bejan J. Saeedi ◽  
Crystal R. Naudin ◽  
Sarah Hunter-Chang ◽  
Maria E. Barbian ◽  
...  
Keyword(s):  
Immune Response ◽  
Lactobacillus Rhamnosus ◽  
Lactobacillus Rhamnosus Gg
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