Serum proteome analysis of vivax malaria: An insight into the disease pathogenesis and host immune response

2012 ◽  
Vol 75 (10) ◽  
pp. 3063-3080 ◽  
Author(s):  
Sandipan Ray ◽  
Karthik S. Kamath ◽  
Rajneesh Srivastava ◽  
Dinesh Raghu ◽  
Kishore Gollapalli ◽  
...  
Keyword(s):  
Immune Response ◽  
Vivax Malaria ◽  
Proteome Analysis ◽  
Host Immune Response ◽  
Disease Pathogenesis ◽  
Serum Proteome ◽  
Insight Into

Signaling and regulation of G-protein coupled receptors encoded by cytomegaloviruses

2004 ◽  
Vol 82 (6) ◽  
pp. 636-642 ◽  
Author(s):  
Melissa P. M Stropes ◽  
William E Miller
Keyword(s):  
Immune Response ◽  
Host Cell ◽  
G Protein ◽  
Host Immune Response ◽  
G Protein Coupled Receptors ◽  
Molecular Regulation ◽  
Virally Encoded ◽  
Species Specific ◽  
G Protein Coupled ◽  
Insight Into

Cytomegaloviruses (CMVs) are species-specific β-herpesviruses whose replicative success is largely due to establishment of novel mechanisms for altering the host immune response. CMV encodes 3 families of putative G-protein coupled receptors (GPCRs) likely pirated from the host cell. While the functions of these virally encoded GPCRs remain unclear, the receptors possess potent signaling abilities. Understanding the molecular regulation of these GPCRs will provide important insight into CMV pathogenesis.Key words: GPCRs, HCMV, GRKs, β-arrestin, US28.

Unravelling some mysteries of porcine respiratory and reproductive syndrome virus (PRRSV) infections: new insights from modelling studies

2009 ◽  
Vol 2009 ◽  
pp. 30-30
Author(s):  
A Doeschl-Wilson ◽  
I Kyriazakis ◽  
L Galina-Pantoja
Keyword(s):  
Immune Response ◽  
Host Immune Response ◽  
Growing Pigs ◽  
Modelling Studies ◽  
Porcine Respiratory ◽  
Insight Into

Porcine reproductive and respiratory syndrome (PRRS) is an endemic pig disease in most European countries, causing respiratory distress, fever and growth reductions in growing pigs and increased litter mortality in sows. The disease is characterised by exceptionally long-term viral persistence within the host, a weak innate host immune response and delayed adaptive host immune response, and large between animal variation in the immune response (Murtaugh et al., 2004). Although numerous in-vitro and in-vivo studies produced valid insight into the fine details of the virus dynamics and its interaction with the host’s immune response, several fundamental questions concerning the role of diverse immune components and host genetics remain unanswered. In this study mathematical models were developed to investigate the role of diverse processes caused by the virus or the immune response on the infection characteristics.

scholarly journals Dual RNAseq of human leprosy lesions identifies bacterial determinants linked to host immune response

2018 ◽  
Author(s):  
Dennis Montoya ◽  
Priscila R. Andrade ◽  
Bruno J. A. Silva ◽  
Rosane M. B. Teles ◽  
Bryan Bryson ◽  
...  
Keyword(s):  
Immune Response ◽  
Transcriptional Activity ◽  
Mycobacterium Leprae ◽  
Host Immune Response ◽  
Gene Signature ◽  
Intracellular Bacterium ◽  
Host Immune System ◽  
Bacterial Burden ◽  
Shock Proteins ◽  
Insight Into

SummaryTo understand how the interaction between an intracellular bacterium and the host immune system contributes to outcome at the site of infection, we studied leprosy, a disease that forms a clinical spectrum, in which progressive infection by the intracellular bacterium Mycobacterium leprae is characterized by the production of type | IFNs and antibody production. We performed dual RNAseq on patient lesions, identifying a continuum of distinct bacterial states that are linked to the host immune response. The bacterial burden, represented by the fraction of bacterial transcripts, correlates with a host type | IFN gene signature, known to inhibit antimicrobial responses. Second, the bacterial transcriptional activity, defined by the bacterial mRNA/rRNA ratio, links bacterial heat shock proteins with the BAFF-BCMA host antibody response pathway. Our findings provide a platform for interrogation of host and pathogen transcriptomes at the site of infection, allowing insight into mechanisms of inflammation in human disease.

scholarly journals Networking the host immune response in Plasmodium vivax malaria

2013 ◽  
Vol 12 (1) ◽  
pp. 69 ◽  
Author(s):  
Vitor RR Mendonça ◽  
Artur TL Queiroz ◽  
Fabrício M Lopes ◽  
Bruno B Andrade ◽  
Manoel Barral-Netto
Keyword(s):  
Immune Response ◽  
Plasmodium Vivax ◽  
Vivax Malaria ◽  
Host Immune Response ◽  
Plasmodium Vivax Malaria

scholarly journals A porcine ligated loop model reveals new insight into the host immune response against Campylobacter jejuni

Gut Microbes ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 1814121
Author(s):  
Nicholas M Negretti ◽  
Yinyin Ye ◽  
Lais M Malavasi ◽  
Swechha M Pokharel ◽  
Steven Huynh ◽  
...  
Keyword(s):  
Immune Response ◽  
Campylobacter Jejuni ◽  
Host Immune Response ◽  
Loop Model ◽  
Insight Into
Sign in / Sign up

Export Citation Format

Share Document