Proteomic profiling of intestinal prechylomicron transport vesicle (PCTV)-associated proteins in an animal model of insulin resistance (94 char)

2010 ◽  
Vol 73 (7) ◽  
pp. 1291-1305 ◽  
Author(s):  
Diana M. Wong ◽  
Jennifer P. Webb ◽  
Paul M. Malinowski ◽  
Elaine Xu ◽  
Joseph Macri ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Animal Model ◽  
Proteomic Profiling ◽  
Transport Vesicle ◽  
Associated Proteins

scholarly journals Neurodegeneration in an animal model of Parkinson's disease is exacerbated by a high-fat diet

2010 ◽  
Vol 299 (4) ◽  
pp. R1082-R1090 ◽  
Author(s):  
Jill K. Morris ◽  
Gregory L. Bomhoff ◽  
John A. Stanford ◽  
Paige C. Geiger
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Model ◽  
Locomotor Activity ◽  
Substantia Nigra ◽  
High Fat Diet ◽  
Model Assessment ◽  
High Fat

Despite numerous clinical studies supporting a link between type 2 diabetes (T2D) and Parkinson's disease (PD), the clinical literature remains equivocal. We, therefore, sought to address the relationship between insulin resistance and nigrostriatal dopamine (DA) in a preclinical animal model. High-fat feeding in rodents is an established model of insulin resistance, characterized by increased adiposity, systemic oxidative stress, and hyperglycemia. We subjected rats to a normal chow or high-fat diet for 5 wk before infusing 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle. Our goal was to determine whether a high-fat diet and the resulting peripheral insulin resistance would exacerbate 6-OHDA-induced nigrostriatal DA depletion. Prior to 6-OHDA infusion, animals on the high-fat diet exhibited greater body weight, increased adiposity, and impaired glucose tolerance. Two weeks after 6-OHDA, locomotor activity was tested, and brain and muscle tissue was harvested. Locomotor activity did not differ between the groups nor did cholesterol levels or measures of muscle atrophy. High-fat-fed animals exhibited higher homeostatic model assessment of insulin resistance (HOMA-IR) values and attenuated insulin-stimulated glucose uptake in fast-twitch muscle, indicating decreased insulin sensitivity. Animals in the high-fat group also exhibited greater DA depletion in the substantia nigra and the striatum, which correlated with HOMA-IR and adiposity. Decreased phosphorylation of HSP27 and degradation of IκBα in the substantia nigra indicate increased tissue oxidative stress. These findings support the hypothesis that a diet high in fat and the resulting insulin resistance may lower the threshold for developing PD, at least following DA-specific toxin exposure.

scholarly journals Kefir reduces insulin resistance and inflammatory cytokine expression in an animal model of metabolic syndrome

2016 ◽  
Vol 7 (8) ◽  
pp. 3390-3401 ◽  
Author(s):  
Damiana D. Rosa ◽  
Łukasz M. Grześkowiak ◽  
Célia L. L. F. Ferreira ◽  
Ana Carolina M. Fonseca ◽  
Sandra A. Reis ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Animal Model ◽  
Inflammatory Cytokine ◽  
Fasting Glucose ◽  
Cytokine Expression ◽  
Fasting Insulin ◽  
Insulin Levels ◽  
Reduce Insulin Resistance

Kefir supplementation in rats with induced metabolic syndrome was able to lower fasting glucose, fasting insulin levels, and reduce insulin resistance.

Proteomic profiling of cell envelope-associated proteins fromStaphylococcus aureus

PROTEOMICS ◽  
2006 ◽  
Vol 6 (5) ◽  
pp. 1530-1549 ◽  
Author(s):  
Christine L. Gatlin ◽  
Rembert Pieper ◽  
Shih-Ting Huang ◽  
Emmanuel Mongodin ◽  
Elizabeth Gebregeorgis ◽  
...  
Keyword(s):  
Cell Envelope ◽  
Proteomic Profiling ◽  
Associated Proteins

Daily Treatment with Sildenafil Reverses Endothelial Dysfunction and Oxidative Stress in an Animal Model of Insulin Resistance

2008 ◽  
Vol 53 (6) ◽  
pp. 1272-1281 ◽  
Author(s):  
Delphine Behr-Roussel ◽  
Alexandra Oudot ◽  
Stéphanie Caisey ◽  
Olivier L.E. Coz ◽  
Diane Gorny ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Animal Model ◽  
Endothelial Dysfunction ◽  
Daily Treatment ◽  
And Oxidative Stress

scholarly journals Central and peripheral insulin resistance in a large animal model of obesity

2011 ◽  
Vol 70 (OCE6) ◽  
Author(s):  
C. L. Adam ◽  
P. A. Findlay ◽  
R. P. Aitken ◽  
J. S. Milne ◽  
J. M. Wallace
Keyword(s):  
Insulin Resistance ◽  
Animal Model ◽  
Large Animal Model ◽  
Large Animal ◽  
Peripheral Insulin Resistance

Insulin Resistance Induced by Zymosan as a New Animal Model in Mice

2013 ◽  
Vol 45 (10) ◽  
pp. 736-740 ◽  
Author(s):  
L.-Y. Wang ◽  
P.-M. Ku ◽  
S.-H. Chen ◽  
H.-H. Chung ◽  
Y.-M. Yu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Animal Model

Impact of chronic gliclazide therapy in the nuclear oxidative stress and insulin-resistance levels in an animal model of diabetes

2006 ◽  
Vol 40 (6) ◽  
pp. 932-933
Author(s):  
Pedro Monteiro ◽  
Elsa Nunes ◽  
Raquel Seiça ◽  
Lino Gonçalves ◽  
Luís A. Providência
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Animal Model
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