scholarly journals The prostaglandin E2/EP4 receptor/cyclic AMP/T-type Ca2+ channel pathway mediates neuritogenesis in sensory neuron-like ND7/23 cells

2016 ◽  
Vol 130 (3) ◽  
pp. 177-180 ◽  
Author(s):  
Kenji Mitani ◽  
Fumiko Sekiguchi ◽  
Takashi Maeda ◽  
Yukari Tanaka ◽  
Shigeru Yoshida ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Prostaglandin E2 ◽  
Sensory Neuron ◽  
Ep4 Receptor

scholarly journals Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

2009 ◽  
Vol 206 (3) ◽  
pp. 535-548 ◽  
Author(s):  
Katia Boniface ◽  
Kristian S. Bak-Jensen ◽  
Ying Li ◽  
Wendy M. Blumenschein ◽  
Mandy J. McGeachy ◽  
...  
Keyword(s):  
Cyclic Amp ◽  
Prostaglandin E2 ◽  
Th17 Cell ◽  
Th17 Cells ◽  
Retinoic Acid Receptor ◽  
Receptor Expression ◽  
Orphan Receptor ◽  
Antiinflammatory Drugs ◽  
Inflammatory Microenvironment ◽  
Ep4 Receptor

Prostaglandins, particularly prostaglandin E2 (PGE2), play an important role during inflammation. This is exemplified by the clinical use of cyclooxygenase 2 inhibitors, which interfere with PGE2 synthesis, as effective antiinflammatory drugs. Here, we show that PGE2 directly promotes differentiation and proinflammatory functions of human and murine IL-17–producing T helper (Th17) cells. In human purified naive T cells, PGE2 acts via prostaglandin receptor EP2- and EP4-mediated signaling and cyclic AMP pathways to up-regulate IL-23 and IL-1 receptor expression. Furthermore, PGE2 synergizes with IL-1β and IL-23 to drive retinoic acid receptor–related orphan receptor (ROR)-γt, IL-17, IL-17F, CCL20, and CCR6 expression, which is consistent with the reported Th17 phenotype. While enhancing Th17 cytokine expression mainly through EP2, PGE2 differentially regulates interferon (IFN)-γ production and inhibits production of the antiinflammatory cytokine IL-10 in Th17 cells predominantly through EP4. Furthermore, PGE2 is required for IL-17 production in the presence of antigen-presenting cells. Hence, the combination of inflammatory cytokines and noncytokine immunomodulators, such as PGE2, during differentiation and activation determines the ultimate phenotype of Th17 cells. These findings, together with the altered IL-12/IL-23 balance induced by PGE2 in dendritic cells, further highlight the crucial role of the inflammatory microenvironment in Th17 cell development and regulation.

scholarly journals Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

2009 ◽  
Vol 184 (6) ◽  
pp. i16-i16
Author(s):  
Katia Boniface ◽  
Kristian S. Bak-Jensen ◽  
Ying Li ◽  
Wendy M. Blumenschein ◽  
Mandy J. McGeachy ◽  
...  
Keyword(s):  
Cell Differentiation ◽  
Cyclic Amp ◽  
Prostaglandin E2 ◽  
Th17 Cell ◽  
Receptor Signaling ◽  
Ep4 Receptor ◽  
Th17 Cell Differentiation ◽  
And Function

scholarly journals A Nonprostanoid EP4 Receptor Selective Prostaglandin E2 Agonist Restores Bone Mass and Strength in Aged, Ovariectomized Rats

2005 ◽  
Vol 21 (4) ◽  
pp. 565-575 ◽  
Author(s):  
Hua Zhu Ke ◽  
D Todd Crawford ◽  
Hong Qi ◽  
Hollis A Simmons ◽  
Thomas A Owen ◽  
...  
Keyword(s):  
Bone Mass ◽  
Prostaglandin E2 ◽  
Ovariectomized Rats ◽  
Ep4 Receptor

scholarly journals Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis

2015 ◽  
Vol 290 (50) ◽  
pp. 29781-29793 ◽  
Author(s):  
Masaki Inada ◽  
Morichika Takita ◽  
Satoshi Yokoyama ◽  
Kenta Watanabe ◽  
Tsukasa Tominari ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Prostaglandin E2 ◽  
Melanoma Cell ◽  
Stromal Cell ◽  
Cell Contact ◽  
Receptor Signaling ◽  
Ep4 Receptor
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