Quantitative determination of multi markers in five varieties of Withania somnifera using ultra-high performance liquid chromatography with hybrid triple quadrupole linear ion trap mass spectrometer combined with multivariate analysis: Application to pharmaceutical dosage forms

2016 ◽  
Vol 129 ◽  
pp. 419-426 ◽  
Author(s):  
Preeti Chandra ◽  
Rekha Kannujia ◽  
Ankita Saxena ◽  
Mukesh Srivastava ◽  
Lal Bahadur ◽  
...  
Keyword(s):  
High Performance ◽  
Withania Somnifera ◽  
Ion Trap ◽  
Dosage Forms ◽  
Linear Ion Trap ◽  
Triple Quadrupole ◽  
Pharmaceutical Dosage Forms ◽  
Ion Trap Mass Spectrometer ◽  
Analysis Application

Fragmentation studies of selected drugs utilized in palliative care

2018 ◽  
Vol 24 (6) ◽  
pp. 420-436 ◽  
Author(s):  
Tomasz Grześkowiak ◽  
Agnieszka Zgoła-Grześkowiak ◽  
Danuta Rusińska-Roszak ◽  
Iwona Zaporowska-Stachowiak ◽  
Magdalena Jeszka-Skowron
Keyword(s):  
Palliative Care ◽  
Mass Spectra ◽  
Ion Trap ◽  
Linear Ion Trap ◽  
Triple Quadrupole ◽  
Hyoscine Butylbromide ◽  
Fragmentation Pathways ◽  
Future Studies ◽  
Ion Trap Mass Spectrometer

The results of research on selected drugs used in palliative care are presented, including fentanyl, tramadol, metoclopramide, hyoscine butylbromide, midazolam, haloperidol, levomepromazine and clonazepam. Interpretation of their ESI mass spectra obtained by the use of a triple quadrupole linear ion trap mass spectrometer is given. As a result, fragmentation pathways described in the literature are complemented and presented with more details. On their basis, transitions for quantitative analysis are selected and chromatographic conditions for the determination of the palliative care drugs are proposed as well. These results enable future studies on palliative care drugs in elderly patients including both their quantitation in body fluids and easier identification of their metabolites.

A rapid and highly sensitive method for simultaneous determination of bioactive constituents in leaf extracts of six Ocimum species using ultra high performance liquid chromatography-hybrid linear ion trap triple quadrupole mass spectrometry

2016 ◽  
Vol 8 (2) ◽  
pp. 333-341 ◽  
Author(s):  
Renu Pandey ◽  
Preeti Chandra ◽  
Brijesh Kumar ◽  
Bhupender Dutt ◽  
Kulwant Rai Sharma
Keyword(s):  
Food Processing ◽  
High Performance ◽  
Ion Trap ◽  
Linear Ion Trap ◽  
Quadrupole Mass ◽  
Bioactive Constituents ◽  
Leaf Extracts ◽  
Highly Sensitive ◽  
Ocimum Species

Ocimum species have tremendous value in pharmaceutical, perfumery, food processing and cosmetic industries, also in traditional rituals and medicines.

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