Development of a UFLC-MS/MS method for the simultaneous determination of seven tea catechins in rat plasma and its application to a pharmacokinetic study after administration of green tea extract

2016 ◽  
Vol 125 ◽  
pp. 229-235 ◽  
Author(s):  
Yanshuang Huo ◽  
Qian Zhang ◽  
Qing Li ◽  
Bingjie Geng ◽  
Kaishun Bi
Keyword(s):  
Simultaneous Determination ◽  
Green Tea ◽  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Green Tea Extract ◽  
Tea Catechins ◽  
Tea Extract

scholarly journals Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration ofRadix Salviae MiltiorrhizaeExtract, Hawthorn Extract, and a Combination of Both Extracts to Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Yu-Qiang Liu ◽  
Qian Cai ◽  
Chang Liu ◽  
Feng-Wei Bao ◽  
Zhen-Qiu Zhang
Keyword(s):  
Oral Administration ◽  
Simultaneous Determination ◽  
Pharmacokinetic Study ◽  
Rosmarinic Acid ◽  
Rat Plasma ◽  
Hplc Method ◽  
Radix Salviae Miltiorrhizae ◽  
Salviae Miltiorrhizae ◽  
Hawthorn Extract

A simple and sensitive HPLC method was developed for simultaneous determination of danshensu (DSS), rosmarinic acid (RA), lithospermic acid (LA), salvianolic acid B (SAB), and hyperoside (HP) in rat plasma. This method validated was successfully applied to the pharmacokinetic study of the main active ingredients after oral administration ofRadix Salviae Miltiorrhizaeextract (SME), hawthorn extract (HTE), and a combination of both extracts (2.5 : 1) to rats. The results indicated that there have been great differences in pharmacokinetics between a single extract and a combination of both extracts. A combination of both extracts can enhance their bioavailabilities and delay the elimination of SAB and DSS in rats.

scholarly journals A UPLC-MS/MS method for simultaneous determination of five flavonoids fromStellera chamaejasmeL. in rat plasma and its application to a pharmacokinetic study

2018 ◽  
Vol 32 (6) ◽  
pp. e4189 ◽  
Author(s):  
Yun-Qing Li ◽  
Cheng-Jian Li ◽  
Lei Lv ◽  
Qing-qing Cao ◽  
Xian Qian ◽  
...  
Keyword(s):  
Simultaneous Determination ◽  
Pharmacokinetic Study ◽  
Rat Plasma
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