High-throughput NIR-chemometric methods for determination of drug content and pharmaceutical properties of indapamide tablets

2013 ◽  
Vol 84 ◽  
pp. 285-292 ◽  
Author(s):  
Ioan Tomuta ◽  
Lucia Rus ◽  
Rares Iovanov ◽  
Luca Liviu Rus
Keyword(s):  
High Throughput ◽  
Chemometric Methods ◽  
Drug Content ◽  
Pharmaceutical Properties

scholarly journals Full spectrum and genetic algorithm-selected spectrum-based chemometric methods for simultaneous determination of azilsartan medoxomil, chlorthalidone, and azilsartan: Development, validation, and application on commercial dosage form

2021 ◽  
Vol 19 (1) ◽  
pp. 205-213
Author(s):  
Hany W. Darwish ◽  
Abdulrahman A. Al Majed ◽  
Ibrahim A. Al-Suwaidan ◽  
Ibrahim A. Darwish ◽  
Ahmed H. Bakheit ◽  
...  
Keyword(s):  
Genetic Algorithm ◽  
Simultaneous Determination ◽  
Predictive Power ◽  
Principal Component Regression ◽  
Selection Procedure ◽  
Principal Component ◽  
Chemometric Methods ◽  
Full Spectrum ◽  
Azilsartan Medoxomil

Abstract Five various chemometric methods were established for the simultaneous determination of azilsartan medoxomil (AZM) and chlorthalidone in the presence of azilsartan which is the core impurity of AZM. The full spectrum-based chemometric techniques, namely partial least squares (PLS), principal component regression, and artificial neural networks (ANN), were among the applied methods. Besides, the ANN and PLS were the other two methods that were extended by genetic algorithm procedure (GA-PLS and GA-ANN) as a wavelength selection procedure. The models were developed by applying a multilevel multifactor experimental design. The predictive power of the suggested models was evaluated through a validation set containing nine mixtures with different ratios of the three analytes. For the analysis of Edarbyclor® tablets, all the proposed procedures were applied and the best results were achieved in the case of ANN, GA-ANN, and GA-PLS methods. The findings of the three methods were revealed as the quantitative tool for the analysis of the three components without any intrusion from the co-formulated excipient and without prior separation procedures. Moreover, the GA impact on strengthening the predictive power of ANN- and PLS-based models was also highlighted.

High-throughput determination of flavanone-O-glycosides in citrus beverages by paper spray tandem mass spectrometry

2021 ◽  
pp. 130060
Author(s):  
Fabio Mazzotti ◽  
Lucia Bartella ◽  
Ines Rosita Talarico ◽  
Anna Napoli ◽  
Leonardo Di Donna
Keyword(s):  
Mass Spectrometry ◽  
Tandem Mass Spectrometry ◽  
High Throughput ◽  
Tandem Mass ◽  
Paper Spray

Determination of Anomalin and Deltoin in Seseli resinosum by LC Combined with Chemometric Methods

2007 ◽  
Vol 66 (9-10) ◽  
pp. 677-683 ◽  
Author(s):  
Alev Tosun ◽  
Özlem Bahadır ◽  
Erdal Dinç
Keyword(s):  
Chemometric Methods

scholarly journals A Sensitive High-Throughput HPLC Assay for Simultaneous Determination of Everolimus and Clobetasol Propionate

2008 ◽  
Vol 46 (1) ◽  
pp. 23-29 ◽  
Author(s):  
K. Marika ◽  
F. Katherine ◽  
L. Jianmin ◽  
C. G. Mike ◽  
F. Debra
Keyword(s):  
Simultaneous Determination ◽  
High Throughput ◽  
Clobetasol Propionate ◽  
Hplc Assay

Rapid, Microscale, Acetyl Bromide-Based Method for High-Throughput Determination of Lignin Content in Arabidopsis thaliana

2008 ◽  
Vol 56 (16) ◽  
pp. 6825-6834 ◽  
Author(s):  
Xue Feng Chang ◽  
Richard Chandra ◽  
Thomas Berleth ◽  
Rodger P. Beatson
Keyword(s):  
Arabidopsis Thaliana ◽  
High Throughput ◽  
Lignin Content ◽  
Acetyl Bromide
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