Analysis of total and unbound hydromorphone in human plasma by ultrafiltration and LC–MS/MS: Application to clinical trial in patients undergoing open heart surgery

2012 ◽  
Vol 71 ◽  
pp. 63-70 ◽  
Author(s):  
Teijo I. Saari ◽  
Jörg Fechner ◽  
Harald Ihmsen ◽  
Jürgen Schüttler ◽  
Christian Jeleazcov
Keyword(s):  
Clinical Trial ◽  
Human Plasma ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart

Effect of rabeprazole of famotidine on peri-operative gastric pH in open heart surgery — A randomized clinical trial

2001 ◽  
Vol 120 (5) ◽  
pp. A730
Author(s):  
Hajime Kuwayama ◽  
Shigeyoshi Gon ◽  
Takao Imazeki ◽  
Hiroshi Kiyama ◽  
Noriyuki Murai ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Gastric Ph ◽  
Open Heart

scholarly journals Open and Closed Endotracheal Suctioning and Arterial Blood Gas Values: A Single-Blind Crossover Randomized Clinical Trial

2015 ◽  
Vol 2015 ◽  
pp. 1-7
Author(s):  
Azam Faraji ◽  
Alireza Khatony ◽  
Gholamreza Moradi ◽  
Alireza Abdi ◽  
Mansour Rezaei
Keyword(s):  
Clinical Trial ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Blood Gases ◽  
Open Heart ◽  
Blood Gas ◽  
Open Technique ◽  
Endotracheal Suctioning ◽  
Arterial Blood Gas ◽  
Arterial Blood

Aim. This study was aimed at comparing the effects of the open and closed suctioning techniques on the arterial blood gas values in patients undergoing open-heart surgery.Methods. In a clinical trial, we recruited 42 patients after open-heart surgery in an educational hospital. Each patient randomly underwent both open and closed suctioning. ABGs, PaO2, SaO2, PaCO2, were analyzed before and one, five, and fifteen minutes after each suctioning episode.Results. At first the pressure of oxygen in arterial blood increased; however, this increase in the open technique was greater than that of the closed system(P<0.001). The pressure of oxygen decreased five and fifteen minutes after both suctioning techniques(P<0.05). The trends of carbon dioxide variations after the open and closed techniques were upward and downward, respectively. Moreover, the decrease in the level of oxygen saturation five and fifteen minutes after the open suctioning was greater than that of the closed suctioning technique(P<0.05).  Conclusion. Arterial blood gas disturbances in the closed suctioning technique were less than those of the open technique. Therefore, to eliminate the unwanted effects of endotracheal suctioning on the arterial blood gases, the closed suctioning technique is recommended.

Effect of rabeprazole of famotidine on peri-operative gastric pH in open heart surgery — A randomized clinical trial

2001 ◽  
Vol 120 (5) ◽  
pp. A730-A730
Author(s):  
H KUWAYAMA ◽  
S GON ◽  
T IMAZEKI ◽  
H KIYAMA ◽  
N MURAI ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Gastric Ph ◽  
Open Heart

scholarly journals Effect of Melatonin on Incidence Rate of Delirium in Elderly Patients Undergoing Open-Heart Surgery without a Pump: A Clinical Trial

2019 ◽  
Author(s):  
Fatemeh Hosseini Kasnavieh ◽  
Hassan Rezaeipandari ◽  
Mehdi Hadadzadeh ◽  
Mahmood Vakili ◽  
Fatemeh Hosseini Biouki
Keyword(s):  
Clinical Trial ◽  
Coronary Artery ◽  
Coronary Artery Bypass ◽  
Coronary Artery Bypass Surgery ◽  
Bypass Surgery ◽  
Heart Surgery ◽  
Artery Bypass ◽  
Open Heart Surgery ◽  
Control Group ◽  
Open Heart

Introduction: Delirium has been considered as the most common cognitive disorder after major surgery. Melatonin therapy is effective in reducing the incidence of delirium after open heart surgery with pain relief mechanism and adjustment of the sleep cycle and the absence of specific side effects. This study was conducted to determine the effectiveness of melatonin on prevention of delirium after coronary artery bypass surgery.   Methods: The double blind randomized controlled clinical trial  recruited 140 patients, equally decided, who underwent  coronary artery bypass surgery in Afshar Hospital, Yazd city, 2016. All participants of the two groups were evaluated for the presence of delirium  on the day of surgery and three days after by the Confusion Assessment Method for ICU (CUM-ICU). Respectively, The intervention and control group received 3 mg melatonin and 3 mg placebo orally before and after the operation. Data were analyzed by Chi-square, T-test, paired t-test and Cochran tests.   Results: The incidence of delirium in the melatonin and the control group was 35.7% and 5.7% on the day of operation, 68.6% and 31.4% three days after the operation, respectively. The results showed that there was a significant difference in the frequency of cognitive test of CAM-ICU on day of surgery and three days after surgery between the two groups (p <0.001).   Conclusion: Despite the efficacy of melatonin therapy in reducing delirium, further studies on the effects of other effective drugs on the treatment of delirium, such as antipsychotics and receptor blockers, should be considered.  

Lifestyle intervention and one-year prognosis of patients following open heart surgery: a randomised clinical trial

2015 ◽  
Vol 24 (11-12) ◽  
pp. 1611-1621 ◽  
Author(s):  
Olga Kadda ◽  
Anastasia Kotanidou ◽  
Athanasios Manginas ◽  
George Stavridis ◽  
Serafim Nanas ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Lifestyle Intervention ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Randomised Clinical Trial ◽  
Open Heart ◽  
One Year
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