Validation and application of a stability-indicating HPLC method for the in vitro determination of gastric and intestinal stability of venlafaxine

2007 ◽  
Vol 43 (5) ◽  
pp. 1854-1859 ◽  
Author(s):  
Ebenezer B. Asafu-Adjaye ◽  
Patrick J. Faustino ◽  
Mobin A. Tawakkul ◽  
Lawrence W. Anderson ◽  
Lawrence X. Yu ◽  
...  
Keyword(s):  
Hplc Method ◽  
Stability Indicating ◽  
Intestinal Stability

scholarly journals A new stability-indicating RP-HPLC method for the determination of dicyclomine hydrochloride and dimethicone combination in tablet dosage forms

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
J. Saroja ◽  
Anantha Lakshmi P.V. ◽  
Y. Rammohan ◽  
D. Divya Reddy
Keyword(s):  
Liquid Chromatography ◽  
Dosage Forms ◽  
Flow Speed ◽  
Hplc Method ◽  
Stability Indicating ◽  
Simultaneous Quantification ◽  
Rp Hplc ◽  
Tablet Formulations ◽  
Tablet Dosage

Abstract Background We describe a “stability-indicating liquid chromatography” technique for the estimation of dimethicone (DEC) and dicyclomine hydrochloride (DEH) in the established tablet formulations. Individual quantification of DEH and DEC was reported. But simultaneous quantification of DEH and DEC was lacking. DEH and DEC were analysed on an “XTerra C18 column (250 mm × 4.6 mm, 5 μm)” with the mobile phase solvent run isocratically with 0.1M K2HPO4-acetonitrile (55:45, v/v) on a flow speed of 1.0 mL/min. Results The chromatographic run period for the DEC and DEH assay was 6.0 min with retention times of 2.134 and 2.865 min, respectively. The method was validated for accuracy (99.453 to 100.417% and 99.703 to 100.303% recovery values for DEH and DEC, respectively), precision (RSV value 0.135% for DEC and 0.171% for DEH), linearity (5–15 μg/mL for DEH and 20–60 μg/mL for DEC), selectivity (no hinderance from excipients) and specificity (no hinderance from degradants) recovery. Conclusion The developed stability-indicating liquid chromatography process was well applied to established tablet formulations.

scholarly journals A Stability-Indicating HPLC Method for the Determination of Nitrosylcobalamin (NO-Cbl), a Novel Vitamin B12 Analog

2014 ◽  
Vol 77 (7-8) ◽  
pp. 581-589 ◽  
Author(s):  
Michael J. Dunphy ◽  
Annette M. Sysel ◽  
Joseph A. Lupica ◽  
Kristie Griffith ◽  
Taylor Sherrod ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Hplc Method ◽  
Stability Indicating
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