scholarly journals (334) BMI associated sex differences in pain reports and resting state functional connectivity in older adults

2016 ◽  
Vol 17 (4) ◽  
pp. S59
Author(s):  
S. Atalla ◽  
J. Gore ◽  
S. Bruehl ◽  
B. Rogers ◽  
M. Dietrich ◽  
...  
Keyword(s):  
Older Adults ◽  
Sex Differences ◽  
Functional Connectivity ◽  
Resting State ◽  
Resting State Functional Connectivity ◽  
Pain Reports

scholarly journals Sex differences in the relationship between cardiorespiratory fitness and brain function in older adulthood

2019 ◽  
Vol 126 (4) ◽  
pp. 1032-1041 ◽  
Author(s):  
Christina J. Dimech ◽  
John A. E. Anderson ◽  
Amber W. Lockrow ◽  
R. Nathan Spreng ◽  
Gary R. Turner
Keyword(s):  
Older Adults ◽  
Sex Differences ◽  
Functional Connectivity ◽  
Cardiorespiratory Fitness ◽  
Resting State ◽  
Brain Function ◽  
Network Integration ◽  
Resting State Functional Connectivity ◽  
Older Adulthood ◽  
Fitness Level

We investigated sex differences in the association between a measure of physical health, cardiorespiratory fitness (CRF), and brain function using resting-state functional connectivity fMRI. We examined these sex differences in the default, frontoparietal control, and cingulo-opercular networks, assemblies of functionally connected brain regions known to be impacted by both age and fitness level. Healthy older adults ( n = 49; 29 women) were scanned to obtain measures of intrinsic connectivity within and across these 3 networks. We calculated global efficiency (a measure of network integration) and local efficiency (a measure of network specialization) using graph theoretical methods. Across all three networks combined, local efficiency was positively associated with CRF, and this was more robust in male versus female older adults. Furthermore, global efficiency was negatively associated with CRF, but only in males. Our findings suggest that in older adults, associations between brain network integrity and physical health are sex-dependent. These results underscore the importance of considering sex differences when examining associations between fitness and brain function in older adulthood. NEW & NOTEWORTHY We examined the association between cardiorespiratory fitness and resting state functional connectivity in several brain networks known to be impacted by age and fitness level. We found significant associations between fitness and measures of network integration and network specialization, but in a sex-dependent manner, highlighting the interplay between sex differences, fitness, and aging brain health. Our findings underscore the importance of considering sex differences when examining associations between fitness and brain function in older adulthood.

scholarly journals The effect of amyloid deposition on longitudinal resting-state functional connectivity in cognitively normal older adults

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Chemin Lin ◽  
Maria Ly ◽  
Helmet T. Karim ◽  
Wenjing Wei ◽  
Beth E. Snitz ◽  
...  
Keyword(s):  
Neural Networks ◽  
Older Adults ◽  
Cognitive Function ◽  
Functional Connectivity ◽  
Resting State ◽  
Clinical Symptoms ◽  
Rate Of Change ◽  
Resting State Functional Connectivity ◽  
Cognitive Changes ◽  
Cognitively Normal

Abstract Background Pathological processes contributing to Alzheimer’s disease begin decades prior to the onset of clinical symptoms. There is significant variation in cognitive changes in the presence of pathology, functional connectivity may be a marker of compensation to amyloid; however, this is not well understood. Methods We recruited 64 cognitively normal older adults who underwent neuropsychological testing and biannual magnetic resonance imaging (MRI), amyloid imaging with Pittsburgh compound B (PiB)-PET, and glucose metabolism (FDG)-PET imaging for up to 6 years. Resting-state MRI was used to estimate connectivity of seven canonical neural networks using template-based rotation. Using voxel-wise paired t-tests, we identified neural networks that displayed significant changes in connectivity across time. We investigated associations among amyloid and longitudinal changes in connectivity and cognitive function by domains. Results Left middle frontal gyrus connectivity within the memory encoding network increased over time, but the rate of change was lower with greater amyloid. This was no longer significant in an analysis where we limited the sample to only those with two time points. We found limited decline in cognitive domains overall. Greater functional connectivity was associated with better attention/processing speed and executive function (independent of time) in those with lower amyloid but was associated with worse function with greater amyloid. Conclusions Increased functional connectivity serves to preserve cognitive function in normal aging and may fail in the presence of pathology consistent with compensatory models.

scholarly journals Developmental sex differences in resting state functional connectivity of amygdala sub-regions

NeuroImage ◽  
2015 ◽  
Vol 115 ◽  
pp. 235-244 ◽  
Author(s):  
Gabriela Alarcón ◽  
Anita Cservenka ◽  
Marc D. Rudolph ◽  
Damien A. Fair ◽  
Bonnie J. Nagel
Keyword(s):  
Sex Differences ◽  
Functional Connectivity ◽  
Resting State ◽  
Resting State Functional Connectivity

scholarly journals Sex Differences in Resting-State Functional Connectivity in Multiple Sclerosis

2013 ◽  
Vol 34 (12) ◽  
pp. 2304-2311 ◽  
Author(s):  
K.A. Koenig ◽  
M.J. Lowe ◽  
J. Lin ◽  
K.E. Sakaie ◽  
L. Stone ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Sex Differences ◽  
Functional Connectivity ◽  
Resting State ◽  
Resting State Functional Connectivity

scholarly journals Resting state functional connectivity in early post-anesthesia recovery is characterized by globally reduced anticorrelations

2019 ◽  
Author(s):  
Tommer Nir ◽  
Yael Jacob ◽  
Kuang-Han Huang ◽  
Arthur E. Schwartz ◽  
Jess W. Brallier ◽  
...  
Keyword(s):  
Older Adults ◽  
Functional Connectivity ◽  
Resting State ◽  
Regions Of Interest ◽  
Resting State Networks ◽  
Resting State Functional Connectivity ◽  
Healthy Human ◽  
Healthy Older Adults ◽  
Human Volunteers ◽  
Resting State Connectivity

ABSTRACTThough a growing body of literature is addressing the possible longer-term cognitive effects of anesthetics, to date no study has delineated the normal trajectory of neural recovery due to anesthesia alone in older adults. We obtained resting state functional magnetic resonance imaging scans on 62 healthy human volunteers between ages forty and eighty before, during, and after sevoflurane (general) anesthesia, in the absence of surgery, as part of a larger study on cognitive function post-anesthesia. Resting state networks expression decreased consistently one hour after emergence from anesthesia. This corresponded to a global reduction in anticorrelated functional connectivity post-anesthesia, seen across individual regions-of-interest. Positively correlated functional connectivity remained constant across peri-anesthetic states. All measures returned to baseline 1 day later, with individual regions-of-interest essentially returning to their pre-anesthesia connectivity levels. These results define normal peri-anesthetic changes in resting state connectivity in healthy older adults.

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