scholarly journals (+)-Naloxone, an Opioid-Inactive Toll-Like Receptor 4 Signaling Inhibitor, Reverses Multiple Models of Chronic Neuropathic Pain in Rats

2012 ◽  
Vol 13 (5) ◽  
pp. 498-506 ◽  
Author(s):  
Susannah S. Lewis ◽  
Lisa C. Loram ◽  
Mark R. Hutchinson ◽  
Chien-Ming Li ◽  
Yingning Zhang ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Multiple Models ◽  
Toll Like Receptor ◽  
Chronic Neuropathic Pain ◽  
Toll Like Receptor 4

scholarly journals Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)

2008 ◽  
Vol 28 (1) ◽  
pp. 20-29 ◽  
Author(s):  
Mark R. Hutchinson ◽  
Yingning Zhang ◽  
Kimberley Brown ◽  
Benjamen D. Coats ◽  
Mitesh Shridhar ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

Changes of Toll-like receptor 4 and its downstream cytokines in spinal cord of rat model of neuropathic pain

2009 ◽  
Vol 28 (8) ◽  
pp. 949-953
Author(s):  
Yu-ming SUN ◽  
Fei-xiang WU ◽  
Xue-rong MIAO ◽  
Xin LU ◽  
Xue-wu XU ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Rat Model ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

Lysozyme elicits pain during nerve injury by neuronal Toll-like receptor 4 activation and has therapeutic potential in neuropathic pain

2019 ◽  
Vol 11 (504) ◽  
pp. eaav4176 ◽  
Author(s):  
Saurabh Yadav ◽  
Avadhesha Surolia
Keyword(s):  
Neuropathic Pain ◽  
Nerve Injury ◽  
Neuronal Excitability ◽  
Therapeutic Potential ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Tlr4 Signaling ◽  
C Fibers ◽  
Enhanced Expression ◽  
Thermal Pain Sensitivity

The role of neuronal Toll-like receptor 4 (TLR4) in nerve injury is being pursued actively. However, the endogenous activation of neuronal TLR4 during neuroinflammation, in absence of the participation of glial TLR4, remains elusive. Here, we identified lysozyme as an endogenous activator of neuronal TLR4 signaling during nerve injury. Upon nerve injury, enhanced expression of lysozyme promoted neuronal hyperexcitability and neuropathic pain. Injections of lysozyme in healthy rats increased their mechanical and thermal pain sensitivity. Likewise, infusion of spinal cord slices with lysozyme increased neuronal excitability typical of neuropathic pain. Our results also showed that lysozyme activated excitability of both Aδ- and C-fibers. Thus, in addition to the discovery of lysozyme as an endogenous ligand for regulating neuronal TLR4 signaling, this study also lays the foundation of our understanding of its role in nervous system pathologies, providing multiple avenues for treating neuroinflammation.

Sign in / Sign up

Export Citation Format

Share Document