Subarachnoid Transplant of a Human Neuronal Cell Line Attenuates Chronic Allodynia and Hyperalgesia After Excitotoxic Spinal Cord Injury in the Rat

2007 ◽  
Vol 8 (1) ◽  
pp. 33-50 ◽  
Author(s):  
Mary J. Eaton ◽  
Stacey Quintero Wolfe ◽  
Miguel Martinez ◽  
Massiel Hernandez ◽  
Cassandra Furst ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Line ◽  
Neuronal Cell ◽  
Neuronal Cell Line ◽  
Human Neuronal Cell ◽  
Cord Injury

scholarly journals Subarachnoid Transplant of the Human Neuronal hNT2.19 Serotonergic Cell Line Attenuates Behavioral Hypersensitivity without Affecting Motor Dysfunction after Severe Contusive Spinal Cord Injury

2011 ◽  
Vol 2011 ◽  
pp. 1-24 ◽  
Author(s):  
Mary J. Eaton ◽  
Eva Widerström-Noga ◽  
Stacey Quintero Wolfe
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Line ◽  
Neuronal Cell ◽  
Thermal Hyperalgesia ◽  
Motor Dysfunction ◽  
Differentiated Cells ◽  
Sensory Effects ◽  
Cord Injury ◽  
Base Of Support

Transplant of cells which make biologic agents that can modulate the sensory and motor responses after spinal cord injury (SCI) would be useful to treat pain and paralysis. To address this need for clinically useful human cells, a unique neuronal cell line that synthesizes and secretes/releases the neurotransmitter serotonin (5HT) was isolated. Hind paw tactile allodynia and thermal hyperalgesia induced by severe contusive SCI were potently reversed after lumbar subarachnoid transplant of differentiated cells, but had no effect on open field motor scores, stride length, foot rotation, base of support, or gridwalk footfall errors associated with the SCI. The sensory effects appeared 1 week after transplant and did not diminish during the 8-week course of the experiment when grafts were placed 2 weeks after SCI. Many grafted cells were still present and synthesizing 5HT at the end of the study. These data suggest that the human neuronal serotonergic hNT2.19 cells can be used as a biologic minipump for receiving SCI-related neuropathic pain, but likely requires intraspinal grafts for motor recovery.

The Proinflammatory Cytokine GITRL Contributes to TRAIL-mediated Neurotoxicity in the HCN-2 Human Neuronal Cell Line

2017 ◽  
Vol 14 (10) ◽  
Author(s):  
Giulia Di Benedetto ◽  
Salvatore Saccone ◽  
Laurence Lempereur ◽  
Nicole Ronsisvalle ◽  
Giuseppe Nocentini ◽  
...  
Keyword(s):  
Cell Line ◽  
Proinflammatory Cytokine ◽  
Neuronal Cell ◽  
Neuronal Cell Line ◽  
Human Neuronal Cell

Studies of a Human Neuron-Like Cell Line in Stroke and Spinal Cord Injury

2003 ◽  
pp. 345-387
Author(s):  
Paul J. Reier ◽  
John Q. Trojanowski ◽  
Virginia M-Y. Lee ◽  
Margaret J. Velardo
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Line ◽  
Cord Injury ◽  
Human Neuron

scholarly journals Neutralization of TRAIL death pathway protects human neuronal cell line from β-amyloid toxicity

2003 ◽  
Vol 10 (1) ◽  
pp. 134-141 ◽  
Author(s):  
G Cantarella ◽  
D Uberti ◽  
T Carsana ◽  
G Lombardo ◽  
R Bernardini ◽  
...  
Keyword(s):  
Cell Line ◽  
Neuronal Cell ◽  
Neuronal Cell Line ◽  
Amyloid Toxicity ◽  
Human Neuronal Cell ◽  
Β Amyloid
Sign in / Sign up

Export Citation Format

Share Document