scholarly journals Comparative investigation of antitumoral effectiveness of Rho-kinase inhibitor Y-27632, pravastatin and atorvastatin in anaplastic thyroid cancer cell culture

2017 ◽  
Vol 3 (2) ◽  
pp. 62-65 ◽  
Author(s):  
Erdinc Nayir ◽  
Selver Cor ◽  
Zuhal Mert Altintas ◽  
Kansu Buyukafsar ◽  
Rukiye Nalan Tiftik ◽  
...  
Keyword(s):  
Cell Culture ◽  
Thyroid Cancer ◽  
Cancer Cell ◽  
Kinase Inhibitor ◽  
Rho Kinase ◽  
Anaplastic Thyroid Cancer ◽  
Comparative Investigation ◽  
Thyroid Cancer Cell ◽  
Rho Kinase Inhibitor

Effects of melatonin on the toxicity and proliferation of human anaplastic thyroid cancer cell line

2021 ◽  
Vol 123 (3) ◽  
pp. 151700
Author(s):  
Marjan Ghorbani-Anarkooli ◽  
Sara Dabirian ◽  
Adib Zendedel ◽  
Hasan Moladoust ◽  
Mohammad hadi Bahadori
Keyword(s):  
Thyroid Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Anaplastic Thyroid Cancer ◽  
Thyroid Cancer Cell ◽  
Thyroid Cancer Cell Line

scholarly journals HDAC Inhibition Induces PD-L1 Expression in a Novel Anaplastic Thyroid Cancer Cell Line

2020 ◽  
Vol 26 (4) ◽  
pp. 2523-2535
Author(s):  
Luca Hegedűs ◽  
Dominika Rittler ◽  
Tamás Garay ◽  
Paul Stockhammer ◽  
Ildikó Kovács ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Anaplastic Thyroid Cancer ◽  
Thyroid Cancer Cell ◽  
Hdac Inhibition ◽  
Thyroid Cancer Cell Line

scholarly journals Substantial intrinsic variability in chemoradiosensitivity of newly established anaplastic thyroid cancer cell-lines

2020 ◽  
Vol 140 (4) ◽  
pp. 337-343
Author(s):  
Sigurdur Gretarsson ◽  
Alexander Nygren ◽  
Ann H. Rosendahl ◽  
Nektaria Mylona ◽  
Elisabeth Kjellén ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Anaplastic Thyroid Cancer ◽  
Cancer Cell Lines ◽  
Thyroid Cancer Cell ◽  
Intrinsic Variability ◽  
Thyroid Cancer Cell Lines

scholarly journals Production of multiple cytokines and induction of cachexia in athymic nude mice by a new anaplastic thyroid carcinoma cell line

2003 ◽  
Vol 179 (3) ◽  
pp. 387-394 ◽  
Author(s):  
JW Chang ◽  
KY Yeh ◽  
YC Shen ◽  
JJ Hsieh ◽  
CK Chuang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Growth Factor ◽  
Cell Line ◽  
Cancer Cell ◽  
Nude Mice ◽  
Cancer Cell Line ◽  
Anaplastic Thyroid Cancer ◽  
Thyroid Cancer Cell ◽  
Athymic Nude Mice ◽  
Thyroid Cancer Cell Line

An anaplastic thyroid cancer cell line, Thena, was recently established in our laboratory following radical thyroidectomy of a patient with anaplastic thyroid cancer. Microscopically, Thena cells were spindle-shaped or small round cells. Thena cells were reactive with cytokeratin AE1/AE3 antibodies, epithelial membrane antigen, interleukin (IL)-6, epithelial growth factor receptor, transforming growth factor (TGF)-alpha, vascular endothelial growth factor, and vimentin. Thena cells secreted high levels of IL-6, leukemia inhibitor factor (LIF), tumor necrosis factor (TNF)-alpha, and TGF-beta1 in the culture supernatants, as determined by enzyme-linked immunosorbent assay. When subcutaneously injected with Thena cells, athymic nude mice developed tumor masses in the skin within 2 weeks. Furthermore, Thena cells induced cachexia in these tumor-bearing mice. High levels of human IL-6, LIF and TGF-beta1 were detected in the mouse sera. To our knowledge, the Thena cell line is the first thyroid cancer cell line reported to induce cachexia in nude mice. This cachectic animal model is worthy of further study to explore the treatment of thyroid cancer-induced cachexia.

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