Regulation of Vascular Cell Adhesion Molecule-1 in Dental Pulp Cells by Interleukin-1β: The Role of Prostanoids

2012 ◽  
Vol 38 (6) ◽  
pp. 774-779 ◽  
Author(s):  
Mei-Chi Chang ◽  
Li-Deh Lin ◽  
Jenny Zwei-Ching Chang ◽  
Chiung-Fang Huang ◽  
Fu-Hsiung Chuang ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Dental Pulp ◽  
Cell Adhesion Molecule ◽  
Dental Pulp Cells ◽  
Vascular Cell Adhesion ◽  
Vascular Cell ◽  
Pulp Cells ◽  
Cell Adhesion Molecule 1

scholarly journals EOLA1 Inhibits Lipopolysaccharide-Induced Vascular Cell Adhesion Molecule-1 Expression by Association with MT2A in ECV304 Cells

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Weiling Leng ◽  
Xiaotian Lei ◽  
Hao Meng ◽  
Xinshou Ouyang ◽  
Ziwen Liang
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Vascular Cell Adhesion ◽  
Vascular Cell ◽  
Vascular Cell Adhesion Molecule ◽  
Regulatory Capacity ◽  
Cell Adhesion Molecule 1 ◽  
Negative Regulatory Role

Our research group firstly discovered endothelial-overexpressed lipopolysaccharide-associated factor 1 (EOLA1, GenBank number AY074889) as a lipopolysaccharide (LPS) responsive gene in ECV304 cells. The previous studies have further demonstrated the association of EOLA1 with metallothionein 2A (MT2A), while the role of EOLA1 during LPS-induced inflammatory response in ECV304 cells is unknown. In this report, we determined the subcellular localization of EOLA1 and the regulatory capacity of EOLA1 on vascular cell adhesion molecule-1 (VCAM-1) in response to LPS in ECV304 cells. Our results show that EOLA1 is broadly diffuse in the cells, and EOLA1 expression is dramatically induced by LPS. EOLA1 knockdown results in significant enhancement of LPS-induced VCAM-1 production. Consistent with this, overexpression of EOLA1 leads to the reduction of LPS-induced VCAM-1 production. Furthermore, MT2A knockdown reduces LPS-induced VCAM-1 production. Collectively, our results demonstrate a negative regulatory role of EOLA1 on LPS-induced VCAM-1 expression involving its association with MT2A in ECV304 cells.

Breast cancer metastasis: Putative therapeutic role of vascular cell adhesion molecule-1

2017 ◽  
Vol 40 (3) ◽  
pp. 199-208 ◽  
Author(s):  
Rohit Sharma ◽  
Rohini Sharma ◽  
Tejinder Pal Khaket ◽  
Chanchala Dutta ◽  
Bornisha Chakraborty ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Cancer Metastasis ◽  
Breast Cancer Metastasis ◽  
Vascular Cell Adhesion ◽  
Vascular Cell ◽  
Cell Adhesion Molecule 1
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