scholarly journals Subfoveal choriocapillaris, Sattler's and Haller's layer thickness predict clinical response to stereotactic radiotherapy in neovascular age-related macular degeneration patients

2019 ◽  
Vol 31 (1) ◽  
pp. 92-94
Author(s):  
Mahdy Ranjbar ◽  
Michelle Prasuhn ◽  
Maximilian Kurz ◽  
Annekatrin Holzhey ◽  
Felix Rommel ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Clinical Response ◽  
Layer Thickness ◽  
Stereotactic Radiotherapy ◽  
Age Related Macular Degeneration ◽  
Age Related

Stereotactic Radiotherapy for Neovascular Age-Related Macular Degeneration

Ophthalmology ◽  
2015 ◽  
Vol 122 (1) ◽  
pp. 138-145 ◽  
Author(s):  
Timothy L. Jackson ◽  
Usha Chakravarthy ◽  
Jason S. Slakter ◽  
Alyson Muldrew ◽  
E. Mark Shusterman ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Stereotactic Radiotherapy ◽  
Age Related Macular Degeneration ◽  
Age Related

Grading Choroidal Neovascular Membrane Regression after Strontium Plaque Radiotherapy; Masked Subjective Evaluation vs Planimetry

2001 ◽  
Vol 11 (3) ◽  
pp. 269-276 ◽  
Author(s):  
A. Jaakkola ◽  
P. Tommila ◽  
L. Laatikainen ◽  
I. Immonen
Keyword(s):  
Macular Degeneration ◽  
Clinical Response ◽  
Quantitative Measurement ◽  
Subjective Evaluation ◽  
Subjective Assessment ◽  
Age Related Macular Degeneration ◽  
Grading System ◽  
Choroidal Neovascular Membrane ◽  
Age Related ◽  
Plaque Radiotherapy

Purpose To analyze angiographic changes in choroidal neovascular membranes (CNVM) after strontium-plaque (90Sr) irradiation for exudative age-related macular degeneration (AMD) using masked measurement of the CNVM areas and a masked subjective comparison of CNVM size and leakage. Methods We studied the baseline, 3, 6, and 12-month angiograms of 19 eyes treated with 90Sr-plaque irradiation for exudative AMD. The area of CNVM-related hyperfluorescence was measured quantitatively, and the angiograms were subjectively evaluated by a masked grader. Results In 7 of the 19 eyes the CNVM-related hyperfluorescence was too scattered to be analyzed by planimetry but masked subjective grading correlated with the clinical response to irradiation. In the remaining 12 eyes, the CNVM decreased in size in 67% of the eyes and showed leakage in 67%. Planimetry and subjective assessment of the size and leakage of the CNVMs similarly reflected the regression after irradiation. Conclusions CNVM size and leakage frequently diminish after 90Sr-plaque irradiation. Quantitative measurement of the CNVM areas, or a grading system based on masked subjective assessment, give similar results for evaluating these changes. Masked subjective grading can be used even in cases where the CNVM is too scattered to be outlined for planimetry.

scholarly journals Correlation between Visual Functions and Retinal Morphology in Eyes with Early and Intermediate Age-Related Macular Degeneration

2020 ◽  
Vol 17 (17) ◽  
pp. 6379
Author(s):  
Rituparna Ghoshal ◽  
Sharanjeet Sharanjeet-Kaur ◽  
Norliza Mohamad Fadzil ◽  
Haliza Abdul Mutalib ◽  
Somnath Ghosh ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Macular Degeneration ◽  
Layer Thickness ◽  
Reading Speed ◽  
Retinal Pigment ◽  
Age Related Macular Degeneration ◽  
Morphological Alteration ◽  
Retinal Layer ◽  
Visual Functions ◽  
Age Related

In early and intermediate age related macular degeneration (ARMD), visual acuity alone has failed to explain the complete variation of vision. The aim of the present study was to determine correlation between different visual functions and retinal morphology in eyes with early and intermediate ARMD. In this single center cross sectional study, patients diagnosed as early or intermediate ARMD in at least one eye were recruited. Visual functions measured were best- corrected distance visual acuity (DVA), near vision acuity (NVA), reading speed (RS), and contrast sensitivity (CS). Parameters such as thickness (RT) and volume (RV) of the retina, outer retinal layer thickness (ORLT) and volume (ORLV), outer nuclear layer thickness (ONLT) and volume (ONLV), retinal pigment epithelium layer-Bruch’s membrane complex thickness (RPET) and volume (RPEV) were assessed employing semi-auto segmentation method of Spectralis optical coherence tomography (OCT). Twenty-six eyes were evaluated. DVA, CS, and RS showed significantly good correlation with RPET, ONLT, and ONLV, whereas NVA showed good correlation with ONLV and RPET. The present study concluded that RS, CS, NVA, and DVA represent the morphological alteration in early stages and should be tested in clinical settings. ONLT, ONLV, and RPET morphological parameters can be employed as important biomarkers in diagnosis of early to intermediate ARMD.

Sign in / Sign up

Export Citation Format

Share Document