scholarly journals Articular cartilage degeneration following anterior cruciate ligament injury: a comparison of surgical transection and noninvasive rupture as preclinical models of post-traumatic osteoarthritis

2016 ◽  
Vol 24 (11) ◽  
pp. 1918-1927 ◽  
Author(s):  
T. Maerz ◽  
M.D. Newton ◽  
M.D. Kurdziel ◽  
P. Altman ◽  
K. Anderson ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Articular Cartilage ◽  
Anterior Cruciate Ligament Injury ◽  
Cruciate Ligament ◽  
Cartilage Degeneration ◽  
Ligament Injury ◽  
Preclinical Models ◽  
Post Traumatic ◽  
Anterior Cruciate ◽  
Articular Cartilage Degeneration

Effect of Remnant-Preserving Reconstruction of Acute Anterior Cruciate Ligament Injuries in a Rabbit Model: Histological and Biomechanical Analysis

2022 ◽  
Vol 12 (5) ◽  
pp. 897-906
Author(s):  
XiaoChen Ju ◽  
Hao Chai ◽  
Sasirekha Krishnan ◽  
Abinaya Jaisankar ◽  
Murugan Ramalingam ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Articular Cartilage ◽  
Acl Reconstruction ◽  
Bone Healing ◽  
Cruciate Ligament ◽  
Cartilage Degeneration ◽  
Remnant Preservation ◽  
Model Animal ◽  
Anterior Cruciate ◽  
Articular Cartilage Degeneration

Acute anterior cruciate ligament (ACL) is a key structure that stabilizes knee joints. The objective of this research is to investigate the influence of ligament remnants preserved on the tendon-bone healing following ACL reconstruction and to examine postoperative articular cartilage degeneration in rabbit as a model animal. Sixty New Zealand rabbits are randomly divided into an ACL reconstruction without remnant preservation group (Group A; n = 30) or ACL reconstruction with remnant preservation group (Group B; n = 30). The expression of HIF-1α, VEGF, and micro vessel density (MVD) in the transplanted tendon was detected by immunohistochemical staining at week 6 and 12 after the operation. The signal intensity of the transplanted tendon was observed by MRI scanning, and the width of the bone tunnel was measured by CT scanning at week 6 and 12 after the operation. The graft biomechanics was tested 12 weeks after the operation. The JNK and MMP-13 expression levels were compared to analyze the cartilage degeneration of the knee at week 12 after the operation. The experimental results were analyzed and showed that the remnant-preserving ACL reconstruction is beneficial for bone healing of the tendon in rabbits, but ACL reconstruction with or without ligament remnants preserved will not affect knee articular cartilage degeneration post-surgery.

scholarly journals Tibial articular cartilage and meniscus geometries combine to influence female risk of anterior cruciate ligament injury

2014 ◽  
Vol 32 (11) ◽  
pp. 1487-1494 ◽  
Author(s):  
Daniel R. Sturnick ◽  
Robert Van Gorder ◽  
Pamela M. Vacek ◽  
Michael J. DeSarno ◽  
Mack G. Gardner-Morse ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Articular Cartilage ◽  
Anterior Cruciate Ligament Injury ◽  
Cruciate Ligament ◽  
Ligament Injury ◽  
Anterior Cruciate

Anterior cruciate ligament injury: post-traumatic bone marrow oedema correlates with long-term prognosis

2015 ◽  
Vol 40 (1) ◽  
pp. 183-190 ◽  
Author(s):  
Giuseppe Filardo ◽  
Elizaveta Kon ◽  
Francesco Tentoni ◽  
Luca Andriolo ◽  
Alessandro Di Martino ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Anterior Cruciate Ligament ◽  
Anterior Cruciate Ligament Injury ◽  
Cruciate Ligament ◽  
Bone Marrow Oedema ◽  
Ligament Injury ◽  
Post Traumatic ◽  
Anterior Cruciate ◽  
Long Term Prognosis
Sign in / Sign up

Export Citation Format

Share Document