scholarly journals Individuals with severe knee OA are at increased risk of all-cause and cardiovascular disease-specific mortality: The johnston county osteoarthritis project

2016 ◽  
Vol 24 ◽  
pp. S36-S37
Author(s):  
R.J. Cleveland ◽  
T.A. Schwartz ◽  
J.M. Jordan ◽  
J.B. Renner ◽  
L.F. Callahan
Keyword(s):  
Cardiovascular Disease ◽  
Knee Oa ◽  
Increased Risk ◽  
Specific Mortality ◽  
Disease Specific Mortality ◽  
Disease Specific

Association of sleep duration with all-cause and disease-specific mortality in US adults

2021 ◽  
pp. jech-2020-215314
Author(s):  
Lili Yang ◽  
Bo Xi ◽  
Min Zhao ◽  
Costan G Magnussen
Keyword(s):  
Cardiovascular Disease ◽  
Sleep Duration ◽  
Proportional Hazards ◽  
Large Population ◽  
Cox Proportional Hazards ◽  
Increased Risk ◽  
Specific Mortality ◽  
Disease Specific Mortality ◽  
Cancer Specific Mortality ◽  
Disease Specific

BackgroundPrevious studies revealed inconsistent findings regarding the association between sleep duration and all-cause and disease-specific mortality. This study aimed to clarify the association of sleep duration with mortality using a large population-based prospective cohort study from the USA.MethodsWe used data from the National Health Interview Survey (2004–2014) linked to National Death Index records to 31 December 2015. A total of 284 754 participants aged ≥18 years were included. Self-reported sleep duration (average time slept in a 24-hour period) was categorised into seven groups: ≤4 hours, 5 hours, 6 hours, 7 hours (reference), 8 hours, 9 hours and ≥10 hours. Study outcomes included all-cause, cardiovascular disease-specific and cancer-specific mortality. Cox proportional hazards models were used to examine the association between sleep duration and mortality.ResultsDuring a median follow-up of 5.25 years, we identified 20 872 deaths, of which 4 129 were cardiovascular disease-related and 5 217 were cancer-related. Compared with 7 hours/day of sleep, both short and long sleep durations were associated with an increased risk of all-cause mortality (≤4 hours: HR=1.46, 95% CI=1.33–1.61; 5 hours: HR=1.22, 95% CI=1.13–1.32; 6 hours: HR=1.10, 95% CI=1.05–1.17; 8 hours: HR=1.22, 95% CI=1.17–1.28; 9 hours: HR=1.41, 95% CI=1.31–1.51; ≥10 hours: HR=2.00, 95% CI=1.88–2.13). Similar results were observed for cardiovascular disease-specific and cancer-specific mortality.ConclusionsOur study indicates that both short (≤6 hours/day) and long (≥8 hours/day) sleep durations increase the risk of mortality compared with sleep of 7 hours/day. A normal sleep duration (about 7 hours) every day is recommended for health benefits.

scholarly journals Mediating-Moderating Effect of Allostatic Load on the Association between Dietary Approaches to Stop Hypertension Diet and All-Cause and Cause-Specific Mortality: 2001–2010 National Health and Nutrition Examination Surveys

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2311 ◽  
Author(s):  
Hind A. Beydoun ◽  
Shuyan Huang ◽  
May A. Beydoun ◽  
Sharmin Hossain ◽  
Alan B. Zonderman
Keyword(s):  
Cardiovascular Disease ◽  
Allostatic Load ◽  
Moderating Effects ◽  
Dash Diet ◽  
Health And Nutrition ◽  
All Cause Mortality ◽  
Specific Mortality ◽  
Disease Specific Mortality ◽  
Cancer Specific Mortality ◽  
Disease Specific

This secondary analysis of survey data examined mediating-moderating effects of allostatic load score (calculated using the Rodriquez method) on the association between nutrient-based Dietary Approaches to Stop Hypertension (DASH) diet score (Mellen Index) and the all-cause and cause-specific mortality risks among 11,630 adults ≥ 30 years of age from the 2001–2010 National Health and Nutrition Examination Surveys with no history of cardiovascular disease or cancer at baseline, and who were followed-up for ~9.35 years. Multivariable models were adjusted for demographic, socioeconomic, lifestyle, and health characteristics. All-cause, cardiovascular disease, and cancer-specific mortality rates were estimated at 6.5%, 1.1%, and 1.9%, respectively. The median DASH total score was 3.0 (range: 1–8) (with 78.3% scoring < 4.5), whereas the median allostatic load score was 3 (range: 0–9). The DASH diet, fiber, and magnesium were negatively correlated with allostatic load, whereas allostatic load predicted higher all-cause mortality, irrespective of the DASH diet. Whereas protein was protective, potassium increased all-cause mortality risk, irrespective of allostatic load. Potassium was protective against cardiovascular disease-specific mortality but was a risk factor for cancer-specific mortality. Although no moderating effects were observed, mediation by the allostatic load on cardiovascular disease-specific mortality was observed for DASH total score and selected component scores. Direct (but not indirect) effects of DASH through the allostatic load were observed for all-cause mortality, and no direct or indirect effects were observed for cancer-specific mortality. From a public health standpoint, the allostatic load may be a surrogate for the preventive effects of the DASH diet and its components on cardiovascular disease-specific mortality risk.

scholarly journals Adolescent Body Mass Index and Cardiovascular Disease–Specific Mortality by Midlife

2017 ◽  
Vol 102 (8) ◽  
pp. 3011-3020 ◽  
Author(s):  
Gilad Twig ◽  
Dana Ben-Ami Shor ◽  
Ariel Furer ◽  
Hagai Levine ◽  
Estela Derazne ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Body Mass Index ◽  
Body Mass ◽  
Specific Mortality ◽  
Disease Specific Mortality ◽  
Disease Specific

scholarly journals Evidence of an oncogenic role of aberrant TOX activation in cutaneous T-cell lymphoma

Blood ◽  
2015 ◽  
Vol 125 (9) ◽  
pp. 1435-1443 ◽  
Author(s):  
Yuanshen Huang ◽  
Ming-Wan Su ◽  
Xiaoyan Jiang ◽  
Youwen Zhou
Keyword(s):  
Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Increased Risk ◽  
Key Points ◽  
Specific Mortality ◽  
Risk Of Disease ◽  
Disease Specific Mortality ◽  
Sézary Cells ◽  
Disease Specific

Key Points TOX is aberrantly expressed in primary Sézary cells and its levels correlate with increased risk of disease-specific mortality. TOX knockdown promotes apoptosis and reduces cell proliferation in CTCL cells, partially through inducing p27 and p57.

scholarly journals Plasma YKL-40 and Total and Disease-Specific Mortality in the General Population

2010 ◽  
Vol 56 (10) ◽  
pp. 1580-1591 ◽  
Author(s):  
Julia S Johansen ◽  
Stig E Bojesen ◽  
Anne Tybjærg-Hansen ◽  
Anne K Mylin ◽  
Paul A Price ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
General Population ◽  
Early Death ◽  
Mortality Rates ◽  
Term Survival ◽  
Hazard Ratios ◽  
Heart Study ◽  
Specific Mortality ◽  
Disease Specific Mortality ◽  
Disease Specific

BACKGROUND Increased plasma YKL-40 is associated with short-term survival in patients with cardiovascular disease and cancer. We tested the hypothesis that increased plasma YKL-40 is associated with total and disease-specific mortality in the general population. METHODS We measured plasma YKL-40 in 8899 study participants, aged 20–95 years, in the Copenhagen City Heart Study from the Danish general population who were followed for 16 years: 3059 died, 2158 had ischemic cardiovascular disease, 2271 had cancer, and 2820 had other diseases associated with increased YKL-40. Hazard ratios for early death and absolute 10-year mortality rates were calculated according to plasma YKL-40 percentile groupings computed within sex and age decade: 0%–33%, 34%–66%, 67%–90%, 91%–95%, and 96%–100%. RESULTS Median survival age decreased from 83 years for participants with plasma YKL-40 in category 0%–33% to 69 years in category 96%–100% (trend, P &lt; 0.0001). Risk of early death was increased (multifactorially adjusted hazard ratios) by 10% for YKL-40 category 34%–66%, by 30% for 67%–90%, by 70% for 91%–95%, and by 90% for 96%–100% vs YKL-40 category 0%–33% (trend, P &lt; 0.0001). Corresponding increases in participants with ischemic cardiovascular disease were 10%, 20%, 80%, and 60% (P &lt; 0.0001); in those with cancer were 10%, 20%, 50%, and 70% (P &lt; 0.0001); and in those with other diseases were 10%, 20%, 40%, and 60% (P &lt; 0.0001). Highest absolute 10-year mortality rates were 78% and 90% in women and men, respectively, who were &gt;70 years old, smoked, and were in YKL-40 category 96%–100%. CONCLUSIONS Increased plasma YKL-40 is associated with risk of early death from cardiovascular disease, cancer, and other diseases in the general population.

scholarly journals Association between body mass index and risk of cardiovascular disease-specific mortality among adults with hypertension in Shanghai, China

Aging ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 6866-6877
Author(s):  
Jing Hu ◽  
Huilin Xu ◽  
Jingjing Zhu ◽  
Jinling Zhang ◽  
Jun Li ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Body Mass Index ◽  
Body Mass ◽  
Specific Mortality ◽  
Disease Specific Mortality ◽  
Disease Specific

scholarly journals Gender Differences in Prognosis after Primary Resection for Retroperitoneal Liposarcoma

2021 ◽  
Author(s):  
Cheng-Xin Weng ◽  
Yu-Han Qi ◽  
Ji-Chun Zhao ◽  
Ding Yuan ◽  
Yi Yang ◽  
...  
Keyword(s):  
Survival Rates ◽  
Radical Resection ◽  
Primary Resection ◽  
Low Grade ◽  
Retroperitoneal Liposarcoma ◽  
Increased Risk ◽  
All Cause Mortality ◽  
Specific Mortality ◽  
Disease Specific Mortality ◽  
Disease Specific

Abstract Background: Current evidence regarding gender difference in retroperitoneal liposarcoma (RLPS) is scarce, we sought to investigate whether gender may affect prognosis after primary resection of RLPS.Methods: We used the Surveillance, Epidemiology, and End Results (SEER) database to identify RLPS patients from January 1973 to December 2015. Multivariate cox proportional hazards analysis was adopted to generate adjusted hazard ratio (AHR) and 95% confidence intervals (CI) of survival outcomes.Results: In total, 2108 RLPS patients, including 971 women and 1137 men, were identified, with a median follow-up of 45.0 (17.0-92.0) months. The 5-year and 10-year overall survival rates were 50.5% and 31.5% for men, and 60.4% and 42.5% for women. The 5-year and 10-year disease-specific survival rates for men and women were 71.5%, 57.3% and 76.3%, 62.1%, respectively. We found men were associated with an increased risk of all-cause mortality (AHR 1.3, 95%CI 1.0-1.6, P=.017) but not disease-specific mortality (AHR 1.2, 95%CI 0.9-1.6, P=.246). The subgroup analyses revealed that men were associated with an increased risk of all-cause mortality in patients with low-grade tumors (AHR 1.8, 95%CI 1.3-2.5) or patients received non-radical resection (AHR 1.6, 95%CI 1.2-2.1). Besides, in the subgroup of low-grade tumors, men were also associated with an increased risk of disease-specific mortality (AHR 2.0, 95%CI 1.2-3.3).Conclusion: Men may have worse survival after primary resection of RLPS compared with women, especially in patients with low-grade tumors or patients received non-radical resection. Gender-based disparities may deserve more attention in patients with RLPS.

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