scholarly journals Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study

2012 ◽  
Vol 20 (11) ◽  
pp. 1217-1226 ◽  
Author(s):  
N. Yoshimura ◽  
S. Muraki ◽  
H. Oka ◽  
S. Tanaka ◽  
H. Kawaguchi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Glucose Tolerance ◽  
Knee Osteoarthritis ◽  
Impaired Glucose Tolerance ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
The Road ◽  
Road Study

FRI0407 Accumulation of metabolic risk factors raises the risk of occurrence and progression of knee osteoarthritis: The road study

2013 ◽  
Vol 71 (Suppl 3) ◽  
pp. 452.1-452
Author(s):  
N. Yoshimura ◽  
S. Muraki ◽  
H. Oka ◽  
S. Tanaka ◽  
H. Kawaguchi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Knee Osteoarthritis ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
The Road ◽  
Road Study

Association of Knee Osteoarthritis with the Accumulation of Metabolic Risk Factors Such as Overweight, Hypertension, Dyslipidemia, and Impaired Glucose Tolerance in Japanese Men and Women: The ROAD Study

2011 ◽  
Vol 38 (5) ◽  
pp. 921-930 ◽  
Author(s):  
NORIKO YOSHIMURA ◽  
SHIGEYUKI MURAKI ◽  
HIROYUKI OKA ◽  
HIROSHI KAWAGUCHI ◽  
KOZO NAKAMURA ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Knee Osteoarthritis ◽  
Impaired Glucose Tolerance ◽  
Large Scale ◽  
Smoking Habit ◽  
Age Groups ◽  
Knee Injuries ◽  
Joint Space Width ◽  
Joint Space ◽  
The Road

Objective.To clarify the association of knee osteoarthritis (KOA) with overweight (OW), hypertension (HTN), dyslipidemia (DL), and impaired glucose tolerance (IGT), which are components of metabolic syndrome (MS), in a Japanese population.Methods.We enrolled 1690 participants (596 men, 1094 women) from the large-scale cohort study Research on Osteoarthritis Against Disability (ROAD), begun in 2005 to clarify epidemiologic features of OA in Japan. KOA was evaluated by the Kellgren-Lawrence grade, minimum joint space width (MJSW), minimum joint space area (JSA), and osteophyte area (OPA). OW, HTN, DL, and IGT were assessed using standard criteria.Results.The prevalence of KOA in the total population in the age groups ≤ 39, 40–49, 50–59, 60–69, 70–79, and ≥ 80 years was 2.2%, 10.7%, 28.2%, 50.8%, 69.0%, and 80.5%, respectively. Logistic regression analyses after adjustment for age, sex, regional difference, smoking habit, alcohol consumption, physical activities, regular exercise, and history of knee injuries revealed that the OR of KOA significantly increased according to the number of MS components present (1 component: OR 1.21, 95% CI 0.88–1.68, p = 0.237; 2 components: OR 1.89, 95% CI 1.33–2.70, p < 0.001; 3 or more components: OR 2.72, 95% CI 1.77–4.18; p < 0.001). The number of MS components was inversely related to medial MSJW (ß = −0.148, R2= 0.21, p < 0.001), medial JSA (women only; ß = −0.096, R2= 0.18, p = 0.001), and positively related to OPA (ß = 0.12, R2= 0.11, p < 0.001).Conclusion.The accumulation of MS components is significantly related to presence of KOA. MS prevention may be useful to reduce cardiovascular disease and KOA risk.

scholarly journals The effectiveness of general practice-based health checks on health behaviour and incidence on non-communicable diseases in individuals with low socioeconomic position: a randomised controlled trial in Denmark

BMJ Open ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. e029180 ◽  
Author(s):  
Nina Kamstrup-Larsen ◽  
Susanne Oksbjerg Dalton ◽  
Morten Grønbæk ◽  
Marie Broholm-Jørgensen ◽  
Janus Laust Thomsen ◽  
...  
Keyword(s):  
Risk Factors ◽  
General Practice ◽  
Health Behaviour ◽  
Intervention Group ◽  
Metabolic Risk Factors ◽  
Health Check ◽  
Control Group ◽  
Metabolic Risk ◽  
Health Checks

BackgroundThe effectiveness of health checks aimed at the general population is disputable. However, it is not clear whether health checks aimed at certain groups at high risk may reduce adverse health behaviour and identify persons with metabolic risk factors and non-communicable diseases (NCDs).ObjectivesTo assess the effect of general practice-based health checks on health behaviour and incidence on NCDs in individuals with low socioeconomic position.MethodsIndividuals with no formal education beyond lower secondary school and aged 45–64 years were randomly assigned to the intervention group of a preventive health check or to control group of usual care in a 1:1 allocation. Randomisation was stratified by gender and 5-year age group. Due to the real-life setting, blinding of participants was only possible in the control group. Effects were analysed as intention to treat (ITT) and per protocol. The trial was undertaken in 32 general practice units in Copenhagen, Denmark.InterventionInvitation to a prescheduled preventive health check from the general practitioner (GP) followed by a health consultation and an offer of follow-up with health risk behaviour change or preventive medical treatment, if necessary.Primary outcome measuresSmoking status at 12-month follow-up. Secondary outcomes included status in other health behaviours such as alcohol consumption, physical activity and body mass index (measured by self-administered questionnaire), as well as incidence of metabolic risk factors and NCDs such as hypertension, hypercholesterolaemia, chronic obstructive pulmonary disease, diabetes mellitus, hypothyroidism, hyperthyroidism and depression (drawn from national healthcare registries).Results1104 participants were included in the study. For the primary outcome, 710 participants were included in the per protocol analysis, excluding individuals who did not attend the health check, and 1104 participants were included in the ITT analysis. At 12-month follow-up, 37% were daily smokers in the intervention group and 37% in the control group (ORs=0.99, 95% CI: 0.76 to 1.30). No difference in health behaviour nor in the incidence of metabolic risk factors and NCDs between the intervention and control group were found. Side effects were comparable across the two groups.ConclusionThe lack of effectiveness may be due to low intensity of intervention, a high prevalence of metabolic risk factors and NCDs among the participants at baseline as well as a high number of contacts with the GPs in general or to the fact that general practices are not an effective setting for prevention.Trial registration numberNCT01979107.

Sign in / Sign up

Export Citation Format

Share Document