scholarly journals Inhibitory effect on key enzymes relevant to acute type-2 diabetes and antioxidative activity of ethanolic extract of Artocarpus heterophyllus stem bark

2016 ◽  
Vol 5 (5) ◽  
pp. 423-429 ◽  
Author(s):  
Basiru Olaitan Ajiboye ◽  
Oluwafemi Adeleke Ojo ◽  
Oluwatosin Adeyonu ◽  
Oluwatosin Imiere ◽  
Isreal Olayide ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Antioxidative Activity ◽  
Ethanolic Extract ◽  
Stem Bark ◽  
Inhibitory Effect ◽  
Acute Type ◽  
Artocarpus Heterophyllus ◽  
Key Enzymes

scholarly journals In vitro antioxidant potential and inhibitory effect of hydro-ethanolic extract from African black velvet tamarind (Dialium indium) pulp on type 2 diabetes linked enzymes

10.5219/911 ◽  
2018 ◽  
Vol 12 (1) ◽  
Author(s):  
Olakunle Bamikole Afolabi ◽  
Omotade Ibidun Oloyede ◽  
Abiodun Ayodele Ojo ◽  
Amos Adeyinka Onansanya ◽  
Shadrach Oludare Agunbiade ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Ethanolic Extract ◽  
Inhibitory Effect ◽  
Antioxidant Potential ◽  
African Black

Caffeic and chlorogenic acids inhibit key enzymes linked to type 2 diabetes (in vitro): a comparative study

2015 ◽  
Vol 26 (2) ◽  
Author(s):  
Ganiyu Oboh ◽  
Odunayo M. Agunloye ◽  
Stephen A. Adefegha ◽  
Ayodele J. Akinyemi ◽  
Adedayo O. Ademiluyi
Keyword(s):  
Type 2 Diabetes ◽  
Chlorogenic Acid ◽  
Caffeic Acid ◽  
Phenolic Acids ◽  
Quinic Acid ◽  
Inhibitory Effect ◽  
Dependent Manner ◽  
Key Enzymes

AbstractChlorogenic acid is a major phenolic compound that forms a substantial part of plant foods and is an ester of caffeic acid and quinic acid. However, the effect of the structures of both chlorogenic and caffeic acids on their antioxidant and antidiabetic potentials have not been fully understood. Thus, this study sought to investigate and compare the interaction of caffeic acid and chlorogenic acid with α-amylase and α-glucosidase (key enzymes linked to type 2 diabetes) activities in vitro.The inhibitory effect of the phenolic acids on α-amylase and α-glucosidase activities was evaluated. Thereafter, their antioxidant activities as typified by their 1,1-diphenyl-2 picrylhydrazyl radical scavenging ability and ferric reducing antioxidant properties were determined.The results revealed that both phenolic acids inhibited α-amylase and α-glucosidase activities in a dose-dependent manner (2–8 μg/mL). However, caffeic acid had a significantly (p<0.05) higher inhibitory effect on α-amylase [ICThe esterification of caffeic acid with quinic acid, producing chlorogenic acid, reduces their ability to inhibit α-amylase and α-glucosidase activities. Thus, the inhibition of α-amylase and α-glucosidase activities by the phenolic acids could be part of the possible mechanism by which the phenolic acids exert their antidiabetic effects.

scholarly journals Acalypha Wilkesiana ‘Java White’: Identification of Some Bioactive Compounds by Gc-Ms and Their Effects on Key Enzymes Linked to Type 2 Diabete

2018 ◽  
Vol 68 (4) ◽  
pp. 425-439 ◽  
Author(s):  
Olajumoke A. Oyebode ◽  
Ochuko L. Erukainure ◽  
Neil A. Koorbanally ◽  
Md. Shahidul Islam
Keyword(s):  
Type 2 Diabetes ◽  
Bioactive Compounds ◽  
Ethanolic Extract ◽  
Stem Bark ◽  
Root Bark ◽  
Plant Parts ◽  
Ms Analysis ◽  
Ethanolic Extracts ◽  
Acalypha Wilkesiana

Abstract In this study, we identified bioactive compounds from the ethanolic extracts of the leaves, stem bark and root bark of Acalypha wilkesiana through GC-MS analysis and investigated the effects of these extracts on some of the enzymes linked to type 2 diabetes. Plant parts were extracted sequentially with ethyl acetate, ethanol and water. GC-MS analysis revealed the presence of long-chain alkyl acids, esters, ketones and alcohols including phytol and phytol acetate along with some secondary metabolites such as xanthone, vitamin E and various types of sterols including stigmasterol, campesterol and sitosterol. Ethanolic extracts of all the parts showed a dose- -dependent inhibition of α-glucosidase and α-amylase activity. The extracts also demonstrated anti-lipase activity. The ethanolic extract of root bark showed the highest inhibition of enzymes compared to other extracts. The EC50 values (concentrations for 50 % inhibition) of α-glucosidase, α-amylase and lipase inhibition were 35.75 ± 1.95, 6.25 ± 1.05 and 101.33 ± 5.21 μg mL-1, resp. The study suggests that A. wilkesiana ethanolic extracts have the ability to inhibit the activity of enzymes linked to type 2 diabetes. Further studies are needed to confirm the responsible bioactive compounds in this regard.

Inhibitory Effect of Garlic, Purple Onion, and White Onion on Key Enzymes Linked with Type 2 Diabetes and Hypertension

2018 ◽  
Vol 16 (1) ◽  
pp. 105-118 ◽  
Author(s):  
Ganiyu Oboh ◽  
Adedayo O. Ademiluyi ◽  
Odunayo M. Agunloye ◽  
Ayokunle Olubode Ademosun ◽  
Bolaji Grace Ogunsakin
Keyword(s):  
Type 2 Diabetes ◽  
Inhibitory Effect ◽  
Key Enzymes

scholarly journals Carbohydrate digestive enzymes are inhibited by Poincianella pluviosa stem bark extract: relevance on type 2 diabetes treatment

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Camila Gabriel Kato-Schwartz ◽  
Anacharis Babeto de Sá-Nakanishi ◽  
Ana Carolina Guidi ◽  
Geferson de Almeida Gonçalves ◽  
Fernanda Giacomini Bueno ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Digestive Enzymes ◽  
Stem Bark ◽  
Bark Extract ◽  
Diabetes Treatment ◽  
Type 2 Diabetes Treatment ◽  
Stem Bark Extract

scholarly journals Among Commercially Available Fruit Juices, Pomegranate Is the Most Effective Inhibitor of PMS-Trypsin Amyloid-Like Fibrils Formation

2019 ◽  
Vol 14 (6) ◽  
pp. 1934578X1985912
Author(s):  
Phanindra Babu Kasi ◽  
Márta Kotormán
Keyword(s):  
Type 2 Diabetes ◽  
Amyloid Fibrils ◽  
Binding Assay ◽  
Inhibitory Effect ◽  
Fruit Juices ◽  
Pomegranate Juice ◽  
Effective Inhibitor ◽  
Parkinson’S Diseases ◽  
Lateral Sclerosis

The formation of amyloid fibrils is associated with many human illnesses, such as Alzheimer’s, Huntington’s, and Parkinson’s diseases, amyotrophic lateral sclerosis, spongiform encephalitis, type 2 diabetes, and primary and secondary systemic amyloidosis. Nutrition contributes to the prevention of these diseases. The aim of our work was to look for commercially available fruit juices that can inhibit the formation of amyloid fibrils. Of the fruit juices that we examined, that of pomegranate was found to be the most effective inhibitory agent using turbidity measurements and Congo red binding assay. According to our experiments, pomegranate juice reduced the amount of PMS-trypsin amyloid-like fibrils to 3.7% at 5-fold dilution compared with the sample without pomegranate. The inhibitory effect of the pomegranate juice was concentration dependent.

scholarly journals Defective antioxidative activity of small dense HDL3 particles in type 2 diabetes: relationship to elevated oxidative stress and hyperglycaemia

Diabetologia ◽  
2005 ◽  
Vol 48 (3) ◽  
pp. 529-538 ◽  
Author(s):  
E. Nob�court ◽  
S. Jacqueminet ◽  
B. Hansel ◽  
S. Chantepie ◽  
A. Grimaldi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Antioxidative Activity
Sign in / Sign up

Export Citation Format

Share Document